{"entity": "researcher", "timestamp": "2026-08-08T16:42:23.271Z", "family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "affiliations": ["Division of Pediatrics, Department of Clinical Sciences, Lund University, Lund, Sweden.", "Lund University Cancer Center, Lund University, Lund, Sweden.", "Lund Stem Cell Center, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395"}}, "publications": [{"entity": "publication", "iuid": "2327ce3d72bd48d988b4642d35ae1d05", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2327ce3d72bd48d988b4642d35ae1d05.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2327ce3d72bd48d988b4642d35ae1d05"}}, "title": "MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma.", "authors": [{"family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "researcher": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}}, {"family": "Andersson", "given": "Stina", "initials": "S", "orcid": "0000-0003-3226-4740", "researcher": {"href": "https://publications.scilifelab.se/researcher/13415a4a70654146ac1c56e009ee31c4.json"}}, {"family": "Hilgert", "given": "Elien", "initials": "E", "orcid": "0000-0002-4715-6972", "researcher": {"href": "https://publications.scilifelab.se/researcher/a09fe68866854929a507cc66f721392b.json"}}, {"family": "Monferrer", "given": "Ezequiel", "initials": "E"}, {"family": "\u00c1lvarez-Hern\u00e1n", "given": "Guadalupe", "initials": "G", "orcid": "0000-0001-5725-6515", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5c136f13154416b8aa895db485856de.json"}}, {"family": "Karakaya", "given": "Sinan", "initials": "S"}, {"family": "Loontiens", "given": "Siebe", "initials": "S", "orcid": "0000-0002-4602-4580", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e652c656ace4c8f947a2d84b4bfa8b5.json"}}, {"family": "Bek", "given": "Jan Willem", "initials": "JW", "orcid": "0000-0003-1337-1970", "researcher": {"href": "https://publications.scilifelab.se/researcher/908c4fb4652842f8b8ea436a2265eaf4.json"}}, {"family": "Gregor", "given": "Tomas", "initials": "T", "orcid": "0000-0002-7974-1316", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c2c049df61f4fe3a4a2918e99158dd2.json"}}, {"family": "Lecomte", "given": "Estelle", "initials": "E"}, {"family": "Magnusson", "given": "Emma", "initials": "E"}, {"family": "Miltenyte", "given": "Enrika", "initials": "E"}, {"family": "Cabirol", "given": "Marie", "initials": "M"}, {"family": "Kyknas", "given": "Michail", "initials": "M", "orcid": "0009-0004-0813-2670", "researcher": {"href": "https://publications.scilifelab.se/researcher/c67634dfede84d038c0d0dc8535eba15.json"}}, {"family": "Engstr\u00f6m", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2399-985X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a002fa86f9c46fea630c84b02419d6a.json"}}, {"family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}, {"family": "Hammarlund", "given": "Emma", "initials": "E", "orcid": "0000-0001-7625-4793", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2b34455bcd94586a8be8a7adeefe7cc.json"}}, {"family": "Rosenblum", "given": "Jared S", "initials": "JS", "orcid": "0000-0001-5941-9082", "researcher": {"href": "https://publications.scilifelab.se/researcher/49b3dd45a5cd494191b4d24e6edb721f.json"}}, {"family": "Noguera", "given": "Rosa", "initials": "R", "orcid": "0000-0003-4546-7459", "researcher": {"href": "https://publications.scilifelab.se/researcher/91dc687d57f947ba9dde1d129e6c8222.json"}}, {"family": "Speleman", "given": "Frank", "initials": "F"}, {"family": "van Nes", "given": "Johan", "initials": "J"}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}], "type": "journal article", "published": "2024-06-21", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "10", "issue": "25", "pages": "eado1583", "issn-l": "2375-2548"}, "abstract": "Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest-enriched gene MOXD1 associates with advanced disease and worse outcome. Further, by using single-cell RNA sequencing data of human neuroblastoma cells and fetal adrenal glands and creating in vivo models of zebrafish, chick, and mouse, we show that MOXD1 is a determinate of tumor development. In addition, we found that MOXD1 expression is highly conserved and restricted to mesenchymal neuroblastoma cells and Schwann cell precursors during healthy development. Our findings identify MOXD1 as a lineage-restricted tumor-suppressor gene in neuroblastoma, potentiating further stratification of these tumors and development of novel therapeutic interventions.", "doi": "10.1126/sciadv.ado1583", "pmid": "38905335", "labels": {"Clinical Genomics Lund": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11192077"}], "notes": [], "created": "2024-11-17T16:35:21.203Z", "modified": "2025-11-10T13:57:53.132Z"}, {"entity": "publication", "iuid": "cfc8974a612b417081421df4d4a32e70", "links": {"self": {"href": "https://publications.scilifelab.se/publication/cfc8974a612b417081421df4d4a32e70.json"}, "display": {"href": "https://publications.scilifelab.se/publication/cfc8974a612b417081421df4d4a32e70"}}, "title": "Trunk neural crest gene MOXD1 affects embryonic development", "authors": [{"family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "researcher": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}}, {"family": "Andersson", "given": "Stina", "initials": "S"}, {"family": "Ferreira", "given": "Manon", "initials": "M", "orcid": "0000-0001-9059-1825", "researcher": {"href": "https://publications.scilifelab.se/researcher/d27aef5015494b018b22352125c0225d.json"}}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}], "type": "posted-content", "published": "2023-08-31", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.08.29.555314", "pmid": null, "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-21T18:42:00.621Z", "modified": "2025-12-18T19:46:34.390Z"}, {"entity": "publication", "iuid": "d101ccc4ae954ebeb335218ebbaf0967", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d101ccc4ae954ebeb335218ebbaf0967.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d101ccc4ae954ebeb335218ebbaf0967"}}, "title": "MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma", "authors": [{"family": "Fredlund", "given": "Elina", "initials": "E", "orcid": "0009-0006-1986-1267", "researcher": {"href": "https://publications.scilifelab.se/researcher/49c035ee375d466e8cb10b230ca51395.json"}}, {"family": "Andersson", "given": "Stina", "initials": "S"}, {"family": "Hilgert", "given": "Elien", "initials": "E", "orcid": "0000-0002-4715-6972", "researcher": {"href": "https://publications.scilifelab.se/researcher/a09fe68866854929a507cc66f721392b.json"}}, {"family": "\u00c1lvarez-Hern\u00e1n", "given": "Guadalupe", "initials": "G", "orcid": "0000-0001-5725-6515", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5c136f13154416b8aa895db485856de.json"}}, {"family": "Monferrer", "given": "Ezequiel", "initials": "E"}, {"family": "Karakaya", "given": "Sinan", "initials": "S"}, {"family": "Gregor", "given": "Tomas", "initials": "T", "orcid": "0000-0002-7974-1316", "researcher": {"href": "https://publications.scilifelab.se/researcher/3c2c049df61f4fe3a4a2918e99158dd2.json"}}, {"family": "Loontiens", "given": "Siebe", "initials": "S", "orcid": "0000-0002-4602-4580", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e652c656ace4c8f947a2d84b4bfa8b5.json"}}, {"family": "Bek", "given": "Jan Willem", "initials": "JW", "orcid": "0000-0003-1337-1970", "researcher": {"href": "https://publications.scilifelab.se/researcher/908c4fb4652842f8b8ea436a2265eaf4.json"}}, {"family": "Lecomte", "given": "Estelle", "initials": "E"}, {"family": "Magnusson", "given": "Emma", "initials": "E"}, {"family": "Miltenyte", "given": "Enrika", "initials": "E"}, {"family": "Cabirol", "given": "Marie", "initials": "M"}, {"family": "Kyknas", "given": "Michail", "initials": "M", "orcid": "0009-0004-0813-2670", "researcher": {"href": "https://publications.scilifelab.se/researcher/c67634dfede84d038c0d0dc8535eba15.json"}}, {"family": "Engstr\u00f6m", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2399-985X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7a002fa86f9c46fea630c84b02419d6a.json"}}, {"family": "Henriksson", "given": "Marie Arsenian", "initials": "MA", "orcid": "0000-0001-6376-7792", "researcher": {"href": "https://publications.scilifelab.se/researcher/e78a2e958a7b4eaaa9aecad01f0e7c57.json"}}, {"family": "Hammarlund", "given": "Emma", "initials": "E", "orcid": "0000-0001-7625-4793", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2b34455bcd94586a8be8a7adeefe7cc.json"}}, {"family": "Noguera", "given": "Rosa", "initials": "R", "orcid": "0000-0003-4546-7459", "researcher": {"href": "https://publications.scilifelab.se/researcher/91dc687d57f947ba9dde1d129e6c8222.json"}}, {"family": "Speleman", "given": "Frank", "initials": "F"}, {"family": "van Nes", "given": "Johan", "initials": "J"}, {"family": "Mohlin", "given": "Sofie", "initials": "S", "orcid": "0000-0002-2458-3963", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e095a99e2c84d52b13973c9d46d128a.json"}}], "type": "posted-content", "published": "2023-01-19", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2023.01.17.524367", "pmid": null, "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2023-11-21T18:41:01.829Z", "modified": "2025-12-18T19:56:22.668Z"}]}