{"entity": "researcher", "timestamp": "2026-07-12T00:07:02.169Z", "family": "Bartolacci", "given": "Caterina", "initials": "C", "orcid": "0000-0003-2002-7721", "affiliations": ["Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/4876eab40d6f496da30ea338ede8e8e1.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/4876eab40d6f496da30ea338ede8e8e1"}}, "publications": [{"entity": "publication", "iuid": "6bfd9db1c38b49c49158044c0155d00d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6bfd9db1c38b49c49158044c0155d00d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6bfd9db1c38b49c49158044c0155d00d"}}, "title": "Thioredoxin Reductase 1 inhibition triggers ferroptosis in KRAS-independent lung cancers.", "authors": [{"family": "Andreani", "given": "Cristina", "initials": "C", "orcid": "0000-0003-3245-670X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ac8d24e06e2949b59784539dc93e9a1e.json"}}, {"family": "Bartolacci", "given": "Caterina", "initials": "C", "orcid": "0000-0003-2002-7721", "researcher": {"href": "https://publications.scilifelab.se/researcher/4876eab40d6f496da30ea338ede8e8e1.json"}}, {"family": "Melegari", "given": "Margherita", "initials": "M", "orcid": "0000-0003-3565-5560", "researcher": {"href": "https://publications.scilifelab.se/researcher/1ad61d725ed8433c9e4469312bcce77f.json"}}, {"family": "Sargentoni", "given": "Nicola", "initials": "N", "orcid": "0009-0009-2735-3440", "researcher": {"href": "https://publications.scilifelab.se/researcher/e478ff01e2e24fe8bbbf3331b125d093.json"}}, {"family": "Luciani", "given": "Lorenzo", "initials": "L", "orcid": "0000-0002-9000-7454", "researcher": {"href": "https://publications.scilifelab.se/researcher/806ba2ac1b9f461eb25549b4b81fd1d9.json"}}, {"family": "Marucci", "given": "Agnese", "initials": "A"}, {"family": "Galeazzi", "given": "Roberta", "initials": "R", "orcid": "0000-0003-1792-654X", "researcher": {"href": "https://publications.scilifelab.se/researcher/891fb9c56107468a8cce385d8bb402b6.json"}}, {"family": "DeNicola", "given": "Gina M", "initials": "GM", "orcid": "0000-0001-6611-6696", "researcher": {"href": "https://publications.scilifelab.se/researcher/e19a7cc8adae4fd482db8d1e44adbf23.json"}}, {"family": "Kilgore", "given": "Jessica", "initials": "J", "orcid": "0000-0001-9138-2099", "researcher": {"href": "https://publications.scilifelab.se/researcher/340f210063894be2b5a7a3edc73a9f64.json"}}, {"family": "Williams", "given": "Noelle", "initials": "N", "orcid": "0000-0003-1894-5742", "researcher": {"href": "https://publications.scilifelab.se/researcher/69f9dcee6ec441abbf0bc8d19b1cdeb2.json"}}, {"family": "Berto", "given": "Stefano", "initials": "S", "orcid": "0000-0001-9028-9458", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e144d40db50454caf117f24e57a320a.json"}}, {"family": "Gaetani", "given": "Massimiliano", "initials": "M", "orcid": "0000-0001-5610-0797", "researcher": {"href": "https://publications.scilifelab.se/researcher/7b58e5cef5224fdcbdcd626fb798b169.json"}}, {"family": "Pattabhi", "given": "Prasad", "initials": "P", "orcid": "0000-0002-8437-7838", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ff340a9b68a46f7b87225a63767f6b9.json"}}, {"family": "Osman", "given": "Sagid S", "initials": "SS"}, {"family": "Mansour", "given": "Ahmad T", "initials": "AT"}, {"family": "Pucciarelli", "given": "Stefania", "initials": "S", "orcid": "0000-0003-2137-5517", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ee3c9bf3ffc485a8686a08aef7e4ca8.json"}}, {"family": "Galassi", "given": "Rossana", "initials": "R", "orcid": "0000-0002-8025-9615", "researcher": {"href": "https://publications.scilifelab.se/researcher/97a7ad071ad4410dad92fe45c56e61e4.json"}}, {"family": "Scaglioni", "given": "Pier Paolo", "initials": "PP", "orcid": "0000-0002-6036-5138", "researcher": {"href": "https://publications.scilifelab.se/researcher/898e0ff87b6949129b39faae85c5346c.json"}}], "type": "journal article", "published": "2025-07-30", "journal": {"title": "bioRxiv", "issn": "2692-8205", "issn-l": null}, "abstract": "Lung cancers that harbor wild type KRAS (KRAS-WT) represent a molecularly diverse subset of tumors that often lack targeted therapeutic options. Using synthesized gold(I)-based inhibitors, a multi-omics approach, and functional validation, we identified Thioredoxin reductase 1 (TXNRD1), encoding as a selective vulnerability in KRAS-WT and oncogenic KRAS mutant (KM)-independent lung cancer (LC). Mechanistically, TRXR1 blockade induces ferroptosis through glutathione depletion, lipid reactive oxygen species (ROS) accumulation, and HMOX1-dependent iron overload in KRAS-WT LC both in vitro and in vivo. Furthermore, while KM LC cells are intrinsically resistant to TRXR1 inhibition, KMLC cells that acquire resistance to KRAS inhibitors (KRASi) undergo a redox shift that renders them sensitive to TRXR1 inhibition, uncovering a potential novel therapeutic vulnerability in KRASi-refractory tumors. These findings establish TRXR1 as a targetable redox checkpoint in KRAS-WT and KRASi-resistant lung cancers and support further development of TRXR1 inhibitors.", "doi": "10.1101/2025.07.25.666783", "pmid": "40766571", "labels": {"Chemical Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC12324224"}, {"db": "pii", "key": "2025.07.25.666783"}, {"db": "figshare", "key": "10.25452/figshare.plus.24667905.v2"}], "notes": [], "created": "2025-11-25T16:35:13.732Z", "modified": "2025-11-25T16:42:16.937Z"}]}