{"entity": "researcher", "timestamp": "2026-07-20T13:44:42.632Z", "family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "affiliations": ["Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04"}}, "publications": [{"entity": "publication", "iuid": "09be553050f342ae982025de836a0afd", "links": {"self": {"href": "https://publications.scilifelab.se/publication/09be553050f342ae982025de836a0afd.json"}, "display": {"href": "https://publications.scilifelab.se/publication/09be553050f342ae982025de836a0afd"}}, "title": "Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity.", "authors": [{"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications.scilifelab.se/researcher/710f1dd1e63e45d39a11d52eb21a5e88.json"}}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR", "orcid": "0000-0001-5331-5522", "researcher": {"href": "https://publications.scilifelab.se/researcher/b411684ce1eb401fb8917def9c2a75a0.json"}}, {"family": "Constantz", "given": "Christian", "initials": "C"}, {"family": "Cai", "given": "Curtis", "initials": "C", "orcid": "0000-0002-3490-4361", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ea25e71e96246d89437270a12cc9e47.json"}}, {"family": "Nils\u00e9n", "given": "Vera", "initials": "V"}, {"family": "Rivera Ballesteros", "given": "Olga", "initials": "O", "orcid": "0000-0001-6949-4270", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b48f38b946d4fbc9d687da130f2e661.json"}}, {"family": "Adamo", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6161-3156", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbdfb6f121014c29a448232b60f32585.json"}}, {"family": "Kammann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-8433-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ead9a21a35e34fd092774ae13a211255.json"}}, {"family": "Mouchtaridi", "given": "Elli", "initials": "E"}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Akhirunnesa", "given": "Mily", "initials": "M", "orcid": "0000-0003-3136-9284", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbce6754eaea4ebfa2437f9572f180ae.json"}}, {"family": "Raineri", "given": "Elisa J M", "initials": "EJM", "orcid": "0000-0002-5468-276X", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fe9b94230d5498f8550c7ad897254e9.json"}}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Stamper", "given": "Christopher", "initials": "C", "orcid": "0000-0002-5568-8880", "researcher": {"href": "https://publications.scilifelab.se/researcher/19710b0b30ca436ca1d29bc89a376ddc.json"}}, {"family": "Marchalot", "given": "Anne", "initials": "A", "orcid": "0000-0002-3042-8206", "researcher": {"href": "https://publications.scilifelab.se/researcher/95b674db5dc349eaa4438563f2256290.json"}}, {"family": "Bassett", "given": "John", "initials": "J", "orcid": "0009-0002-5785-5088", "researcher": {"href": "https://publications.scilifelab.se/researcher/5cc9841bc436476492288239d3bb0fff.json"}}, {"family": "Ferreira", "given": "Sabrina", "initials": "S"}, {"family": "Rodahl", "given": "Inga", "initials": "I"}, {"family": "Wild", "given": "Nicole", "initials": "N", "orcid": "0000-0002-4009-473X", "researcher": {"href": "https://publications.scilifelab.se/researcher/17325f3df80248f7a1b4985094a86d7c.json"}}, {"family": "Stellaccio", "given": "Teresa", "initials": "T", "orcid": "0009-0002-5224-0893", "researcher": {"href": "https://publications.scilifelab.se/researcher/ddfda0141dd948a6b1cd6289b2c5e7f2.json"}}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e879a6ef8ff45bea049986707480e99.json"}}, {"family": "Ringqvist", "given": "Emma", "initials": "E", "orcid": "0000-0001-6303-6076", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfad17442063471cb570d5be1c4dbc48.json"}}, {"family": "Flodstr\u00f6m-Tullberg", "given": "Malin", "initials": "M", "orcid": "0000-0003-2685-2052", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb6d04afbe8141c2b9297854de64dab8.json"}}, {"family": "Llewellyn-Lacey", "given": "Sian", "initials": "S", "orcid": "0000-0002-4703-0413", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a952db761ab4e66b251f69c00d14990.json"}}, {"family": "Tibbitt", "given": "Chris", "initials": "C", "orcid": "0000-0002-7730-7700", "researcher": {"href": "https://publications.scilifelab.se/researcher/6d8a6804b0be4aba9a9256dd2df71656.json"}}, {"family": "Hammer", "given": "Quirin", "initials": "Q", "orcid": "0000-0003-2968-6061", "researcher": {"href": "https://publications.scilifelab.se/researcher/3b6b2e5256c8401f83c3f89b5c5bb92f.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Price", "given": "David A", "initials": "DA", "orcid": "0000-0001-9416-2737", "researcher": {"href": "https://publications.scilifelab.se/researcher/2dd5567af7984233b164e6906d4daaca.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications.scilifelab.se/researcher/fcca878a7f314944bf1a4290cfd5d71d.json"}}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications.scilifelab.se/researcher/b87ccad53d354bdd80af490dc8a0c019.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04.json"}}, {"family": "Jorns", "given": "Carl", "initials": "C", "orcid": "0000-0001-7727-8113", "researcher": {"href": "https://publications.scilifelab.se/researcher/59d387bd893f45bdb3663a0ef3aae88a.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}], "type": "journal article", "published": "2025-07-18", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "10", "issue": "109", "pages": "eadq4881", "issn-l": null}, "abstract": "CD8+ T cells are classically defined by cytotoxic activity, but it has remained unclear whether cytotoxic programs are compartmentalized across tissues and memory subsets. Here, we established a human organ donor cohort and found that expression of conventional cytotoxic molecules-granulysin, perforin, and granzyme B-was most prominent among circulating memory CD8+ T cells and decreased progressively with tissue residency, inversely mirroring the expression of CD69 and CD103. Other cytotoxic molecules, including granzymes A, H, K, and M, were variably expressed across tissues, and memory CD8+ T cells targeting persistent viruses expressed multiple granzymes coordinately. In an in vitro tonsil system, transforming growth factor-\u03b2 induced discordant regulation of cytotoxic molecules and CD103. Combined with interleukin-15, this circuitry modulated proliferation and the acquisition of redirected killing activity via perforin and granzyme B. Our findings suggest that human memory CD8+ T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and antigen specificity.", "doi": "10.1126/sciimmunol.adq4881", "pmid": "40680144", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [], "notes": [], "created": "2025-10-13T13:28:04.756Z", "modified": "2025-11-25T21:31:43.911Z"}, {"entity": "publication", "iuid": "789627b839e9496699453ecee2d8b1c1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/789627b839e9496699453ecee2d8b1c1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/789627b839e9496699453ecee2d8b1c1"}}, "title": "MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles.", "authors": [{"family": "Kammann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-8433-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ead9a21a35e34fd092774ae13a211255.json"}}, {"family": "Cai", "given": "Curtis", "initials": "C", "orcid": "0000-0002-3490-4361", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ea25e71e96246d89437270a12cc9e47.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04.json"}}, {"family": "Mouchtaridi", "given": "Elli", "initials": "E"}, {"family": "Boulouis", "given": "Caroline", "initials": "C"}, {"family": "Nils\u00e9n", "given": "Vera", "initials": "V"}, {"family": "Ballesteros", "given": "Olga Rivera", "initials": "OR", "orcid": "0000-0001-6949-4270", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b48f38b946d4fbc9d687da130f2e661.json"}}, {"family": "M\u00fcller", "given": "Thomas R", "initials": "TR", "orcid": "0000-0001-5331-5522", "researcher": {"href": "https://publications.scilifelab.se/researcher/b411684ce1eb401fb8917def9c2a75a0.json"}}, {"family": "Gao", "given": "Yu", "initials": "Y"}, {"family": "Raineri", "given": "Elisa J M", "initials": "EJM", "orcid": "0000-0002-5468-276X", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fe9b94230d5498f8550c7ad897254e9.json"}}, {"family": "Mily", "given": "Akhirunnesa", "initials": "A", "orcid": "0000-0003-3136-9284", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbce6754eaea4ebfa2437f9572f180ae.json"}}, {"family": "Adamo", "given": "Sarah", "initials": "S", "orcid": "0000-0002-6161-3156", "researcher": {"href": "https://publications.scilifelab.se/researcher/dbdfb6f121014c29a448232b60f32585.json"}}, {"family": "Constantz", "given": "Christian", "initials": "C"}, {"family": "Niessl", "given": "Julia", "initials": "J", "orcid": "0000-0001-8852-1924", "researcher": {"href": "https://publications.scilifelab.se/researcher/710f1dd1e63e45d39a11d52eb21a5e88.json"}}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Stamper", "given": "Christopher", "initials": "C", "orcid": "0000-0002-5568-8880", "researcher": {"href": "https://publications.scilifelab.se/researcher/19710b0b30ca436ca1d29bc89a376ddc.json"}}, {"family": "Marchalot", "given": "Anne", "initials": "A"}, {"family": "Bassett", "given": "John", "initials": "J"}, {"family": "Ferreira", "given": "Sabrina", "initials": "S"}, {"family": "R\u00f8dahl", "given": "Inga", "initials": "I"}, {"family": "Wild", "given": "Nicole", "initials": "N", "orcid": "0000-0002-4009-473X", "researcher": {"href": "https://publications.scilifelab.se/researcher/17325f3df80248f7a1b4985094a86d7c.json"}}, {"family": "Brownlie", "given": "Demi", "initials": "D", "orcid": "0000-0001-5932-6425", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e879a6ef8ff45bea049986707480e99.json"}}, {"family": "Tibbitt", "given": "Chris", "initials": "C", "orcid": "0000-0002-7730-7700", "researcher": {"href": "https://publications.scilifelab.se/researcher/6d8a6804b0be4aba9a9256dd2df71656.json"}}, {"family": "Mak", "given": "Jeffrey Y W", "initials": "JYW", "orcid": "0000-0002-8011-4539", "researcher": {"href": "https://publications.scilifelab.se/researcher/a3b541f7d3b043989ab612d5f2678ee0.json"}}, {"family": "Fairlie", "given": "David P", "initials": "DP", "orcid": "0000-0002-7856-8566", "researcher": {"href": "https://publications.scilifelab.se/researcher/35fe17dcf6bb494f9c95e2dfab5ada19.json"}}, {"family": "Leeansyah", "given": "Edwin", "initials": "E", "orcid": "0000-0003-0505-4967", "researcher": {"href": "https://publications.scilifelab.se/researcher/51b242a952354b35a15be094a7436ac2.json"}}, {"family": "Michaelsson", "given": "Jakob", "initials": "J"}, {"family": "Marquardt", "given": "Nicole", "initials": "N", "orcid": "0000-0003-3186-4752", "researcher": {"href": "https://publications.scilifelab.se/researcher/b87ccad53d354bdd80af490dc8a0c019.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications.scilifelab.se/researcher/fcca878a7f314944bf1a4290cfd5d71d.json"}}, {"family": "Jorns", "given": "Carl", "initials": "C", "orcid": "0000-0001-7727-8113", "researcher": {"href": "https://publications.scilifelab.se/researcher/59d387bd893f45bdb3663a0ef3aae88a.json"}}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}], "type": "journal article", "published": "2024-09-06", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "9", "issue": "99", "pages": "eadn2362", "issn-l": null}, "abstract": "Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor-matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor dependent with distinct tissue compartmentalization patterns and adaptations: Intestinal CD103+ resident MAIT cells presented an immunoregulatory CD39highCD27low profile, whereas MAIT cells expressing NCAM1/CD56 dominated in the liver and exhibited enhanced effector capacity with elevated response magnitude and polyfunctionality. Both intestinal CD39high and hepatic CD56+ adaptations accumulated with donor age. CD56+ MAIT cells displayed limited T cell receptor-repertoire breadth, elevated MR1 binding, and a transcriptional profile skewed toward innate activation pathways. Furthermore, CD56 was dynamically up-regulated to a persistent steady-state equilibrium after exposure to antigen or IL-7. In summary, we demonstrate functional heterogeneity and tissue site adaptation in resident MAIT cells across human barrier tissues with distinct regulatory and effector signatures.", "doi": "10.1126/sciimmunol.adn2362", "pmid": "39241054", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-14T22:47:27.625Z", "modified": "2024-11-14T22:47:29.014Z"}, {"entity": "publication", "iuid": "6e2a1fc431c64a6086d711f8beca0048", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6e2a1fc431c64a6086d711f8beca0048.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6e2a1fc431c64a6086d711f8beca0048"}}, "title": "MAIT cell activation and dynamics associated with COVID-19 disease severity.", "authors": [{"family": "Parrot", "given": "Tiphaine", "initials": "T", "orcid": "0000-0001-9625-6825", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ae2982949a644f59bcfc88d0e3bf9c4.json"}}, {"family": "Gorin", "given": "Jean-Baptiste", "initials": "JB", "orcid": "0000-0003-4605-1375", "researcher": {"href": "https://publications.scilifelab.se/researcher/a623ffbc0a19427aabd47ad6f047e49d.json"}}, {"family": "Ponzetta", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3224-802X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b06c3ab1bae404dba4ec9a1eee4f78b.json"}}, {"family": "Maleki", "given": "Kimia T", "initials": "KT", "orcid": "0000-0001-5382-5477", "researcher": {"href": "https://publications.scilifelab.se/researcher/b691252c7d7446788d0a10f0648ef47f.json"}}, {"family": "Kammann", "given": "Tobias", "initials": "T", "orcid": "0000-0002-8433-036X", "researcher": {"href": "https://publications.scilifelab.se/researcher/ead9a21a35e34fd092774ae13a211255.json"}}, {"family": "Emg\u00e5rd", "given": "Johanna", "initials": "J"}, {"family": "Perez-Potti", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-5998-5700", "researcher": {"href": "https://publications.scilifelab.se/researcher/fbfe371f142840bc9470b37777ac1f2f.json"}}, {"family": "Sekine", "given": "Takuya", "initials": "T", "orcid": "0000-0001-7649-0593", "researcher": {"href": "https://publications.scilifelab.se/researcher/42434c4f0f504dcd82e5830a727d5a04.json"}}, {"family": "Rivera-Ballesteros", "given": "Olga", "initials": "O", "orcid": "0000-0001-6949-4270", "researcher": {"href": "https://publications.scilifelab.se/researcher/8b48f38b946d4fbc9d687da130f2e661.json"}}, {"family": "Karolinska COVID-19 Study Group", "given": "", "initials": ""}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f7958a9ee7748cf8806253a7aeef673.json"}}, {"family": "Rooyackers", "given": "Olav", "initials": "O", "orcid": "0000-0002-3391-5448", "researcher": {"href": "https://publications.scilifelab.se/researcher/52f4fd2e5e204e598aa5087ff3f13680.json"}}, {"family": "Folkesson", "given": "Elin", "initials": "E", "orcid": "0000-0002-6585-6235", "researcher": {"href": "https://publications.scilifelab.se/researcher/82777b8f48324c58bcad72799d71fd4a.json"}}, {"family": "Eriksson", "given": "Lars I", "initials": "LI"}, {"family": "Norrby-Teglund", "given": "Anna", "initials": "A", "orcid": "0000-0001-9372-1795", "researcher": {"href": "https://publications.scilifelab.se/researcher/25c11b43fc984bbca28fcc5bbf211d58.json"}}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}, {"family": "Aleman", "given": "Soo", "initials": "S"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a54e4b5136642eeafa77ac5118a0c81.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Str\u00e5lin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0002-8801-3169", "researcher": {"href": "https://publications.scilifelab.se/researcher/a6ffa1185f4142b7ab7c372c0c139df6.json"}}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications.scilifelab.se/researcher/7468c415a46645a3a4c3d28badcff954.json"}}], "type": "journal article", "published": "2020-09-28", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "5", "issue": "51", "issn-l": null}, "abstract": "Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.", "doi": "10.1126/sciimmunol.abe1670", "pmid": "32989174", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "5/51/eabe1670"}, {"db": "pmc", "key": "PMC7857393"}], "notes": [], "created": "2020-12-10T16:30:01.335Z", "modified": "2021-11-10T12:47:01.812Z"}]}