{"entity": "researcher", "timestamp": "2026-07-13T10:02:23.476Z", "family": "Karrenberg", "given": "Sophie", "initials": "S", "orcid": "0000-0002-7146-588X", "affiliations": ["Department of Ecology and Genetics; Evolutionary Biology Center; Uppsala University; Uppsala Sweden"], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb"}}, "publications": [{"entity": "publication", "iuid": "109d08b7139947779a648f3aea19ed7a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/109d08b7139947779a648f3aea19ed7a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/109d08b7139947779a648f3aea19ed7a"}}, "title": "Genetic structure and diversity of the declining orchid Gymnadenia conopsea in Scandinavia: implications for conservation and management", "authors": [{"family": "S\u00f6derquist", "given": "Linus", "initials": "L", "orcid": "0000-0002-9894-4119", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a0c370d6402423284ea40a2f51179ae.json"}}, {"family": "Joffard", "given": "Nina", "initials": "N", "orcid": "0000-0003-3712-6080", "researcher": {"href": "https://publications.scilifelab.se/researcher/fae9d351d1d14a129908a73c37ff5728.json"}}, {"family": "Scofield", "given": "Douglas G", "initials": "DG", "orcid": "0000-0001-5235-6461", "researcher": {"href": "https://publications.scilifelab.se/researcher/62a8063a48a446a7947d55f9900894a6.json"}}, {"family": "Milesi", "given": "Pascal", "initials": "P", "orcid": "0000-0001-8580-4291", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f59e048cc6a4159a1829885b370d978.json"}}, {"family": "Karrenberg", "given": "Sophie", "initials": "S", "orcid": "0000-0002-7146-588X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb.json"}}, {"family": "Sletvold", "given": "Nina", "initials": "N", "orcid": "0000-0002-9868-3449", "researcher": {"href": "https://publications.scilifelab.se/researcher/e342483c6e3f44c29453f9bc5ce5bb05.json"}}], "type": "journal-article", "published": "2025-07-00", "journal": {"title": "Ecography", "issn": "0906-7590", "volume": "2025", "issue": "7", "issn-l": null}, "abstract": null, "doi": "10.1111/ecog.07628", "pmid": null, "labels": {"NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2025-09-08T11:33:58.539Z", "modified": "2025-11-28T10:51:06.434Z"}, {"entity": "publication", "iuid": "ce86c408ca0b4ec2817b2742ac8f7e03", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ce86c408ca0b4ec2817b2742ac8f7e03.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ce86c408ca0b4ec2817b2742ac8f7e03"}}, "title": "Genetic differentiation and diversity do not explain variation in heterosis or inbreeding depression: empirical evidence from a long-lived iteroparous plant", "authors": [{"family": "S\u00f6derquist", "given": "Linus", "initials": "L", "orcid": "0000-0002-9894-4119", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a0c370d6402423284ea40a2f51179ae.json"}}, {"family": "Karrenberg", "given": "Sophie", "initials": "S", "orcid": "0000-0002-7146-588X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb.json"}}, {"family": "Sletvold", "given": "Nina", "initials": "N", "orcid": "0000-0002-9868-3449", "researcher": {"href": "https://publications.scilifelab.se/researcher/e342483c6e3f44c29453f9bc5ce5bb05.json"}}], "type": "journal-article", "published": "2024-09-17", "journal": {"title": "Conserv Genet", "issn": "1566-0621", "issn-l": null}, "abstract": null, "doi": "10.1007/s10592-024-01641-7", "pmid": null, "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI SNP genotyping": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [], "notes": [], "created": "2024-10-21T11:15:02.010Z", "modified": "2024-10-21T11:15:02.042Z"}, {"entity": "publication", "iuid": "9c68253c983c4dd8b33da093c868b3ba", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9c68253c983c4dd8b33da093c868b3ba.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9c68253c983c4dd8b33da093c868b3ba"}}, "title": "A polygenic architecture with habitat-dependent effects underlies ecological differentiation in Silene.", "authors": [{"family": "Gramlich", "given": "Susanne", "initials": "S", "orcid": "0000-0003-1224-0514", "researcher": {"href": "https://publications.scilifelab.se/researcher/49a7319974c04884b77987640ab92994.json"}}, {"family": "Liu", "given": "Xiaodong", "initials": "X", "orcid": "0000-0001-8839-2659", "researcher": {"href": "https://publications.scilifelab.se/researcher/fabce70bd90a4bfe8923d6167e236cff.json"}}, {"family": "Favre", "given": "Adrien", "initials": "A", "orcid": "0000-0001-6132-2992", "researcher": {"href": "https://publications.scilifelab.se/researcher/c6992fd6e45a41ffb6fe4aa2a11e812a.json"}}, {"family": "Buerkle", "given": "C Alex", "initials": "CA", "orcid": "0000-0003-4222-8858", "researcher": {"href": "https://publications.scilifelab.se/researcher/3f8582095a674055b811170719618d0b.json"}}, {"family": "Karrenberg", "given": "Sophie", "initials": "S", "orcid": "0000-0002-7146-588X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "New Phytol.", "issn": "1469-8137", "issn-l": "0028-646X", "volume": "235", "issue": "4", "pages": "1641-1652"}, "abstract": "Ecological differentiation can drive speciation but it is unclear how the genetic architecture of habitat-dependent fitness contributes to lineage divergence. We investigated the genetic architecture of cumulative flowering, a fitness component, in second-generation hybrids between Silene dioica and Silene latifolia transplanted into the natural habitat of each species. We used reduced-representation sequencing and Bayesian sparse linear mixed models (BSLMMs) to analyze the genetic control of cumulative flowering in each habitat. Our results point to a polygenic architecture of cumulative flowering. Allelic effects were mostly beneficial or deleterious in one habitat and neutral in the other. Positive-effect alleles often were derived from the native species, whereas negative-effect alleles, at other loci, tended to originate from the non-native species. We conclude that ecological differentiation is governed and maintained by many loci with small, habitat-dependent effects consistent with conditional neutrality. This pattern may result from differences in selection targets in the two habitats and from environmentally dependent deleterious load. Our results further suggest that selection for native alleles and against non-native alleles acts as a barrier to gene flow between species.", "doi": "10.1111/nph.18260", "pmid": "35586969", "labels": {"NGI Short read": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9544174"}, {"db": "Dryad", "key": "10.5061/dryad.4tmpg4fcn"}], "notes": [], "created": "2022-11-09T15:42:31.295Z", "modified": "2024-01-16T13:48:35.574Z"}, {"entity": "publication", "iuid": "3fb8c298d49140d092a8dc83561ec1bb", "links": {"self": {"href": "https://publications.scilifelab.se/publication/3fb8c298d49140d092a8dc83561ec1bb.json"}, "display": {"href": "https://publications.scilifelab.se/publication/3fb8c298d49140d092a8dc83561ec1bb"}}, "title": "Genetic architecture of traits associated with reproductive barriers in Silene: Coupling, sex chromosomes and variation.", "authors": [{"family": "Liu", "given": "Xiaodong", "initials": "X"}, {"family": "Karrenberg", "given": "Sophie", "initials": "S", "orcid": "0000-0002-7146-588X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3a982636b44f4b93b7ec0bd64e5d6bfb.json"}}], "type": "journal article", "published": "2018-10-00", "journal": {"volume": "27", "issn": "1365-294X", "issue": "19", "pages": "3889-3904", "title": "Mol. Ecol.", "issn-l": "0962-1083"}, "abstract": "The evolution of reproductive barriers and their underlying genetic architecture is of central importance for the formation of new species. Reproductive barriers can be controlled either by few large-effect loci suggesting strong selection on key traits, or by many small-effect loci, consistent with gradual divergence or with selection on polygenic or multiple traits. Genetic coupling between reproductive barrier loci further promotes divergence, particularly divergence with ongoing gene flow. In this study, we investigated the genetic architectures of ten morphological, phenological and life history traits associated with reproductive barriers between the hybridizing sister species Silene dioica and S. latifolia; both are dioecious with XY-sex determination. We used quantitative trait locus (QTL) mapping in two reciprocal F 2 crosses. One to six QTLs per trait, including nine major QTLs (PVE > 20%), were detected on 11 of the 12 linkage groups. We found strong evidence for coupling of QTLs for uncorrelated traits and for an important role of sex chromosomes in the genetic architectures of reproductive barrier traits. Unexpectedly, QTLs detected in the two F2 crosses differed largely, despite limited phenotypic differences between them and sufficient statistical power. The widely dispersed genetic architectures of traits associated with reproductive barriers suggest gradual divergence or multifarious selection. Coupling of the underlying QTLs likely promoted divergence with gene flow in this system. The low congruence of QTLs between the two crosses further points to variable and possibly redundant genetic architectures of traits associated with reproductive barriers, with important implications for the evolutionary dynamics of divergence and speciation.", "doi": "10.1111/mec.14562", "pmid": "29577481", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "Dryad", "key": "10.5061/dryad.8dt0gd1"}], "notes": [], "created": "2019-01-07T22:26:08.993Z", "modified": "2021-06-21T14:03:55.838Z"}]}