{"entity": "researcher", "timestamp": "2026-07-12T17:51:41.310Z", "family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "affiliations": ["From the, Department of Clinical Sciences Malm\u00f6, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945"}}, "publications": [{"entity": "publication", "iuid": "f26f0c3b05174ceebc02a8fca7a9c62b", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f26f0c3b05174ceebc02a8fca7a9c62b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f26f0c3b05174ceebc02a8fca7a9c62b"}}, "title": "Dysregulation of MMP2-dependent TGF-\u00df2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis.", "authors": [{"family": "Singh", "given": "Pratibha", "initials": "P"}, {"family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "researcher": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945.json"}}, {"family": "Cavalera", "given": "Michele", "initials": "M"}, {"family": "Al-Sharify", "given": "Dania", "initials": "D"}, {"family": "Matthes", "given": "Frank", "initials": "F", "orcid": "0000-0002-5115-8831", "researcher": {"href": "https://publications.scilifelab.se/researcher/00f734f5167a4de48f38bcdf5e5765ab.json"}}, {"family": "Barghouth", "given": "Mohammad", "initials": "M"}, {"family": "Tengryd", "given": "Christoffer", "initials": "C"}, {"family": "Dun\u00e9r", "given": "Pontus", "initials": "P"}, {"family": "Persson", "given": "Ana", "initials": "A"}, {"family": "Sundius", "given": "Lena", "initials": "L"}, {"family": "Nitulescu", "given": "Mihaela", "initials": "M"}, {"family": "Bengtsson", "given": "Eva", "initials": "E"}, {"family": "Rattik", "given": "Sara", "initials": "S"}, {"family": "Engelbertsen", "given": "Daniel", "initials": "D"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Nilsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-9752-7479", "researcher": {"href": "https://publications.scilifelab.se/researcher/8777140448bc47f0a7984db3c15c0e23.json"}}, {"family": "Monaco", "given": "Claudia", "initials": "C", "orcid": "0000-0003-1985-4914", "researcher": {"href": "https://publications.scilifelab.se/researcher/4597888d83b145719b897bf26dc05e4a.json"}}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2691-9192", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4d8310d9d834bd791b791424774b989.json"}}], "type": "journal article", "published": "2024-12-09", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "10464", "issn-l": "2041-1723"}, "abstract": "Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. Plaques from type 2 diabetes patients have less collagen. Interestingly, lower levels of transforming growth factor-\u00df distinguish type 2 diabetes plaques and, in these patients, lower levels of fibrous repair markers are associated with cardiovascular events. Transforming growth factor-\u00df2 originates mostly from contractile vascular smooth muscle cells that interact with synthetic vascular smooth muscle cells in the cap, leading to collagen formation and vascular smooth muscle cell differentiation. This is regulated by free transforming growth factor-\u00df2 which is affected by hyperglycemia. Our findings underscore the importance of transforming growth factor-\u00df2-driven fibrous repair in type 2 diabetes as an area for future therapeutic strategies.", "doi": "10.1038/s41467-024-50753-8", "pmid": "39653743", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11628557"}, {"db": "pii", "key": "10.1038/s41467-024-50753-8"}, {"db": "GEO", "key": "GSE159677"}], "notes": [], "created": "2025-11-25T19:20:16.367Z", "modified": "2025-11-25T19:20:16.548Z"}, {"entity": "publication", "iuid": "f61c6bdd2de747f392055a5d9c4b6c9a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a"}}, "title": "Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events.", "authors": [{"family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "researcher": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945.json"}}, {"family": "Singh", "given": "Pratibha", "initials": "P"}, {"family": "\u00d6sterlund", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Melander", "given": "Olle", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2691-9192", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4d8310d9d834bd791b791424774b989.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "volume": "290", "issue": "4", "pages": "855-865", "issn-l": "0954-6820"}, "abstract": "Apoptosis is central in both diabetes and atherosclerosis, linked to pancreatic beta cell death and plaque progression. Circulating Caspase-3 has also been associated with diabetes and coronary calcium score. Here, we explored if soluble Caspase-3 (sCaspase-3) is associated with cardio-metabolic risk factors and predicts incidence of diabetes and coronary artery disease (CAD).\n\nClinical data and plasma from 4637 individuals from the Malm\u00f6 Diet and Cancer cohort were studied. Plasma sCaspase-3 was measured by a Proximity Extension Assay. National registers were used to identify diabetes and CAD events during follow-up. Type 2 diabetes risk variants and expression quantitative trait loci (eQTL) for sCaspase-3 were retrieved from the DIAGRAM consortium and the Genotype-Tissue Expression project.\n\nHbA1c was the factor with the strongest association with sCaspase-3 (r = 0.18, P = 1.3x10-36 ). During follow-up 666 individuals developed diabetes and 648 individuals suffered from CAD. Increasing sCaspase-3 was associated with a higher risk of developing diabetes (hazard ratio (HR) 1.18 per 1unit; P = 7 \u00d7 10-5 ) and CAD (HR 1.2 per 1 unit, P = 1 \u00d7 10-4 ) during follow-up. A genetic variant rs60780116, located upstream of CASP3, showed strong association with type 2 diabetes (OR 1.06, 95%CI 1.04-1.07, P = 8.4 \u00d7 10-11 ). An eQTL was identified between this variant and gene expression of CASP3, where the allele positively correlated with type 2 diabetes was associated with increased CASP3 expression in blood.\n\nThe present study provides evidence for plasma sCaspase-3 as a marker of cardio-metabolic risk factors and as a predictor of future diabetes and CAD in a cohort without cardiovascular disease or diabetes at baseline.", "doi": "10.1111/joim.13327", "pmid": "34309093", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2021-12-10T09:10:01.585Z", "modified": "2021-12-10T09:10:01.790Z"}]}