{"entity": "researcher", "timestamp": "2026-07-19T19:27:51.081Z", "family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M", "orcid": "0000-0002-6081-9101", "affiliations": ["Department of Obstetrics and Gynecology, University of Gothenburg, Gothenburg, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06"}}, "publications": [{"entity": "publication", "iuid": "5fb5fa2c98ce45d987c2ea90cb96920a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5fb5fa2c98ce45d987c2ea90cb96920a"}}, "title": "Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.", "authors": [{"family": "Strunz", "given": "Benedikt", "initials": "B", "orcid": "0000-0001-9974-6133", "researcher": {"href": "https://publications.scilifelab.se/researcher/ad80512007054aa9a3632660c0657c50.json"}}, {"family": "Bister", "given": "Jonna", "initials": "J"}, {"family": "J\u00f6nsson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-8389-975X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb54cd37d49c401a9b32067fca10ac47.json"}}, {"family": "Filipovic", "given": "Iva", "initials": "I", "orcid": "0000-0002-8166-5500", "researcher": {"href": "https://publications.scilifelab.se/researcher/cfe34a0a54954684bd1e405afd479ab3.json"}}, {"family": "Crona-Guterstam", "given": "Ylva", "initials": "Y", "orcid": "0000-0003-4998-4904", "researcher": {"href": "https://publications.scilifelab.se/researcher/be2bb2deeaf2411fac4aac4627016cf2.json"}}, {"family": "Kvedaraite", "given": "Egle", "initials": "E", "orcid": "0000-0001-5308-092X", "researcher": {"href": "https://publications.scilifelab.se/researcher/78502177bad3453a8d3ed96d4ad334ac.json"}}, {"family": "Sleiers", "given": "Natalie", "initials": "N", "orcid": "0000-0002-9378-8145", "researcher": {"href": "https://publications.scilifelab.se/researcher/07af0b70210044bdb8ec575101ac49c0.json"}}, {"family": "Dumitrescu", "given": "Bogdan", "initials": "B", "orcid": "0000-0002-9986-3396", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0d9af82119645cd83cbc1aaffe1a967.json"}}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M", "orcid": "0000-0002-6081-9101", "researcher": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06.json"}}, {"family": "Lentini", "given": "Antonio", "initials": "A", "orcid": "0000-0003-1239-5495", "researcher": {"href": "https://publications.scilifelab.se/researcher/e282901d24c64b16a540eff0d57776f4.json"}}, {"family": "Reinius", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-7021-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/bb82c502293d424cb266e1c4e405485f.json"}}, {"family": "Cornillet", "given": "Martin", "initials": "M", "orcid": "0000-0001-7981-0927", "researcher": {"href": "https://publications.scilifelab.se/researcher/aad5c88284e54bd0af1e3ce4004dd24c.json"}}, {"family": "Willinger", "given": "Tim", "initials": "T"}, {"family": "Gidl\u00f6f", "given": "Sebastian", "initials": "S"}, {"family": "Hamilton", "given": "Russell S", "initials": "RS", "orcid": "0000-0002-0598-3793", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f0bb3c84fa244afbf1372666d603479.json"}}, {"family": "Ivarsson", "given": "Martin A", "initials": "MA"}, {"family": "Bj\u00f6rkstr\u00f6m", "given": "Niklas K", "initials": "NK", "orcid": "0000-0002-0967-076X", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf38521350ae490099f01bda1d10be4c.json"}}], "type": "journal article", "published": "2021-02-19", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "issn-l": null, "volume": "6", "issue": "56", "pages": "eabb7800"}, "abstract": "Immune cell differentiation is critical for adequate tissue-specific immune responses to occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells). These cells reside in a tissue undergoing constant regeneration and represent the major leukocyte population at the maternal-fetal interface. However, their physiological response during the menstrual cycle and in pregnancy remains elusive. By surface proteome and transcriptome analysis as well as using humanized mice, we identify a differentiation pathway of uNK cells in vitro and in vivo with sequential acquisition of killer cell immunoglobulin-like receptors and CD39. uNK cell differentiation occurred continuously in response to the endometrial regeneration and was driven by interleukin-15. Differentiated uNK cells displayed reduced proliferative capacity and immunomodulatory function including enhanced angiogenic capacity. By studying human uterus transplantation and monozygotic twins, we found that the uNK cell niche could be replenished from circulation and that it was under genetic control. Together, our study uncovers a continuous differentiation pathway of human NK cells in the uterus that is coupled to profound functional changes in response to local tissue regeneration and pregnancy.", "doi": "10.1126/sciimmunol.abb7800", "pmid": "33617461", "labels": {"Cellular Immunomonitoring": "Service"}, "xrefs": [{"db": "pii", "key": "6/56/eabb7800"}], "notes": [], "created": "2021-02-23T20:18:56.191Z", "modified": "2021-12-09T08:31:54.136Z"}, {"entity": "publication", "iuid": "f47165e073754170af219aa11ee5f6b8", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f47165e073754170af219aa11ee5f6b8.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f47165e073754170af219aa11ee5f6b8"}}, "title": "Proteomic analysis of follicular fluid during human ovulation.", "authors": [{"family": "Zakerkish", "given": "Farnosh", "initials": "F"}, {"family": "Br\u00e4nnstr\u00f6m", "given": "Mats", "initials": "M", "orcid": "0000-0002-6081-9101", "researcher": {"href": "https://publications.scilifelab.se/researcher/3349b0acffde45d3807643f8d6a61e06.json"}}, {"family": "Carlsohn", "given": "Elisabet", "initials": "E"}, {"family": "Sihlbom", "given": "Carina", "initials": "C"}, {"family": "van der Post", "given": "Sjoerd", "initials": "S"}, {"family": "Thoroddsen", "given": "Asgeir", "initials": "A"}], "type": "journal article", "published": "2020-07-00", "journal": {"volume": "99", "issn": "1600-0412", "issue": "7", "title": "Acta Obstet Gynecol Scand", "pages": "917-924", "issn-l": "0001-6349"}, "abstract": "Human ovulation is a biologically complex process that involves several biochemical factors, promoting follicular rupture and release of a fertilizable oocyte. Proteins which are present in follicular fluid at high concentrations during ovulation are likely to be active participants in the biochemical pathways of ovulation. The aim of the study was to identify, by use of a modern proteomic technique, proteins of human follicular fluid which are differentially regulated during ovulation of the natural menstrual cycle.\n\nThis prospective experimental study over 3 years included women planned for laparoscopic sterilization. During surgery, retrieval of the dominant follicle was performed either at the preovulatory stage or during ovulation. Four women of preovulatory phase and four women of ovulatory phase met the predetermined criteria of hormone levels for respective phases, and samples of these were finally included out of the 15 women operated. Follicular fluid was aspirated from the excised follicle and subjected to mass spectrometry with the isobaric tags for relative and absolute quantification (iTRAQ) technology for isobaric tagging of peptides. This enables simultaneous identification and quantification of proteins. The protein profiles of the follicular fluid of the preovulatory phase and the ovulatory phase were analyzed, and proteins that were present were identified.\n\nA total of 502 proteins were identified, several of which previously have not been identified in human follicular fluid. Of the 115 proteins that were found in all samples, 20 proteins were at higher levels during ovulation. These were inflammatory-related proteins, coagulation factors, proteins in lipid metabolism, complement factors and antioxidants. Five proteins were present in lower levels during ovulation, with three being enzymes and the other two proteins of lipid metabolism and iron transport.\n\nTwenty-five follicular fluid proteins, with differential regulation during ovulation, were identified in human follicular fluid of the natural menstrual cycle. These proteins may have essential roles in the ovulatory cascade.", "doi": "10.1111/aogs.13805", "pmid": "31945183", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [], "notes": [], "created": "2020-01-27T22:40:51.450Z", "modified": "2024-01-16T13:46:30.943Z"}]}