{"entity": "researcher", "timestamp": "2026-05-15T02:03:51.659Z", "family": "Wisgrill", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9833-9499", "affiliations": ["Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.", "Exposome Austria, Research Infrastructure and National EIRENE Hub, Vienna, Austria."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/32c01d645e1946f4a7174c8f8878d54d.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/32c01d645e1946f4a7174c8f8878d54d"}}, "publications": [{"entity": "publication", "iuid": "ac19adf0d3404aa687ad8a49eb00c6fe", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ac19adf0d3404aa687ad8a49eb00c6fe.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ac19adf0d3404aa687ad8a49eb00c6fe"}}, "title": "Network analysis reveals age- and virus-specific circuits in nasal epithelial cells of extremely premature infants.", "authors": [{"family": "Wisgrill", "given": "Lukas", "initials": "L", "orcid": "0000-0001-9833-9499", "researcher": {"href": "https://publications.scilifelab.se/researcher/32c01d645e1946f4a7174c8f8878d54d.json"}}, {"family": "Martens", "given": "Anke", "initials": "A", "orcid": "0000-0001-5774-5650", "researcher": {"href": "https://publications.scilifelab.se/researcher/ff034529539a47eeb0548c5ceff5a365.json"}}, {"family": "Kasbauer", "given": "Rajmund", "initials": "R"}, {"family": "Eigenschink", "given": "Michael", "initials": "M", "orcid": "0000-0001-6469-5014", "researcher": {"href": "https://publications.scilifelab.se/researcher/937c22ecea85475fb8dde2b2ca8aa883.json"}}, {"family": "Pummer", "given": "Linda", "initials": "L"}, {"family": "Redlberger-Fritz", "given": "Monika", "initials": "M", "orcid": "0000-0001-6265-557X", "researcher": {"href": "https://publications.scilifelab.se/researcher/6a23b5e0c68f4633acae557350ba6a53.json"}}, {"family": "V\u00e9gv\u00e1ri", "given": "\u00c1kos", "initials": "\u00c1", "orcid": "0000-0002-1287-0906", "researcher": {"href": "https://publications.scilifelab.se/researcher/74be6e7c877e4f0da6c7ed3747f3ef9d.json"}}, {"family": "Warth", "given": "Benedikt", "initials": "B", "orcid": "0000-0002-6104-0706", "researcher": {"href": "https://publications.scilifelab.se/researcher/51d385ac37f442a5b1fb8fe64ce23dbb.json"}}, {"family": "Berger", "given": "Angelika", "initials": "A", "orcid": "0000-0001-6876-5497", "researcher": {"href": "https://publications.scilifelab.se/researcher/e108926b03184a55aa8a187af987c8ee.json"}}, {"family": "Fyhrquist", "given": "Nanna", "initials": "N", "orcid": "0000-0002-5408-0005", "researcher": {"href": "https://publications.scilifelab.se/researcher/b072b498b2014b12930d1fa1dbb3f30a.json"}}, {"family": "Alenius", "given": "Harri", "initials": "H", "orcid": "0000-0003-0106-8923", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f88b2c54fe044a1b76ed7107677c11a.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "Allergy", "issn": "1398-9995", "volume": "79", "issue": "11", "pages": "3062-3081", "issn-l": "0105-4538"}, "abstract": "Viral respiratory infections significantly affect young children, particularly extremely premature infants, resulting in high hospitalization rates and increased health-care burdens. Nasal epithelial cells, the primary defense against respiratory infections, are vital for understanding nasal immune responses and serve as a promising target for uncovering underlying molecular and cellular mechanisms.\n\nUsing a trans-well pseudostratified nasal epithelial cell system, we examined age-dependent developmental differences and antiviral responses to influenza A and respiratory syncytial virus through systems biology approaches.\n\nOur studies revealed differences in innate-receptor repertoires, distinct developmental pathways, and differentially connected antiviral network circuits between neonatal and adult nasal epithelial cells. Consensus network analysis identified unique and shared cellular-viral networks, emphasizing highly relevant virus-specific pathways, independent of viral replication kinetics.\n\nThis research highlights the importance of nasal epithelial cells in innate antiviral immune responses and offers crucial insights that allow for a deeper understanding of age-related differences in nasal epithelial cell immunity following respiratory virus infections.", "doi": "10.1111/all.16196", "pmid": "38898695", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-25T10:26:43.233Z", "modified": "2025-02-28T14:20:05.193Z"}]}