{"entity": "researcher", "timestamp": "2026-08-07T18:53:14.964Z", "family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0001-5413-204X", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/2b9eaa6a5dfc4ecf8bf82ece793cd457.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/2b9eaa6a5dfc4ecf8bf82ece793cd457"}}, "publications": [{"entity": "publication", "iuid": "e51b393a38794d448b63eda5594d8adf", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e51b393a38794d448b63eda5594d8adf.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e51b393a38794d448b63eda5594d8adf"}}, "title": "Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.", "authors": [{"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications.scilifelab.se/researcher/e70c845d32264b448e0b4631b826be6d.json"}}, {"family": "Grassmann", "given": "Felix", "initials": "F"}, {"family": "Dahl", "given": "Leo", "initials": "L", "orcid": "0000-0003-1492-3052", "researcher": {"href": "https://publications.scilifelab.se/researcher/d4df506f315c4289935b935a503efd56.json"}}, {"family": "Dimitriou", "given": "Marios", "initials": "M", "orcid": "0000-0001-8362-2099", "researcher": {"href": "https://publications.scilifelab.se/researcher/531c153359bb400fb48c7324a3bd69ad.json"}}, {"family": "McLeod", "given": "Dianna", "initials": "D"}, {"family": "Gabrielson", "given": "Marike", "initials": "M"}, {"family": "Smith-Byrne", "given": "Karl", "initials": "K"}, {"family": "Thomas", "given": "Cecilia E", "initials": "CE", "orcid": "0000-0001-6201-6380", "researcher": {"href": "https://publications.scilifelab.se/researcher/3a1156f987764218af202efbd76c31fd.json"}}, {"family": "Huang", "given": "Tzu-Hsuan", "initials": "TH", "orcid": "0000-0003-0650-582X", "researcher": {"href": "https://publications.scilifelab.se/researcher/009096335007406698aba18720a4455a.json"}}, {"family": "Forsberg", "given": "Simon K G", "initials": "SKG", "orcid": "0000-0002-7451-9222", "researcher": {"href": "https://publications.scilifelab.se/researcher/e97a399d54a94d56aa6cbd62425e27f6.json"}}, {"family": "Eriksson", "given": "Per", "initials": "P", "orcid": "0000-0001-7633-403X", "researcher": {"href": "https://publications.scilifelab.se/researcher/97fea086745a40e9a3a20baba08bb7b8.json"}}, {"family": "Ulfstedt", "given": "Mikael", "initials": "M"}, {"family": "Johansson", "given": "Mattias", "initials": "M"}, {"family": "Sokolov", "given": "Aleksandr V", "initials": "AV"}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}, {"family": "Hall", "given": "Per", "initials": "P"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications.scilifelab.se/researcher/aba5822711b246b397fffacb7ae403b3.json"}}, {"family": "Czene", "given": "Kamila", "initials": "K"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0001-5413-204X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b9eaa6a5dfc4ecf8bf82ece793cd457.json"}}], "type": "journal article", "published": "2023-11-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "7680", "issn-l": "2041-1723"}, "abstract": "Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association between protein levels, clinical characteristics, and gene variants, and to identify proteins with a causal role in breast cancer. We present 812 cis-acting protein quantitative trait loci for 737 proteins which are used as instruments in Mendelian randomisation analyses of breast cancer risk. Of those, we present five proteins (CD160, DNPH1, LAYN, LRRC37A2 and TLR1) that show a potential causal role in breast cancer risk with confirmatory results in independent cohorts. Our study suggests that these proteins should be further explored as biomarkers and potential drug targets in breast cancer.", "doi": "10.1038/s41467-023-43485-8", "pmid": "37996402", "labels": {"Affinity Proteomics Uppsala": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10667261"}, {"db": "pii", "key": "10.1038/s41467-023-43485-8"}], "notes": [], "created": "2023-11-29T18:54:00.962Z", "modified": "2024-01-16T13:48:31.653Z"}, {"entity": "publication", "iuid": "0f41cddd0a724aad8eebbd2eee4e75e2", "links": {"self": {"href": "https://publications.scilifelab.se/publication/0f41cddd0a724aad8eebbd2eee4e75e2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/0f41cddd0a724aad8eebbd2eee4e75e2"}}, "title": "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.", "authors": [{"family": "Jhun", "given": "Min-A", "initials": "M"}, {"family": "Mendelson", "given": "Michael", "initials": "M", "orcid": "0000-0001-7590-3958", "researcher": {"href": "https://publications.scilifelab.se/researcher/d30230bbef094ca6831089c8e4afc846.json"}}, {"family": "Wilson", "given": "Rory", "initials": "R", "orcid": "0000-0001-6135-3764", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c107a0ec79f4672b6ec73ff4273c338.json"}}, {"family": "Gondalia", "given": "Rahul", "initials": "R"}, {"family": "Joehanes", "given": "Roby", "initials": "R", "orcid": "0000-0001-5549-9054", "researcher": {"href": "https://publications.scilifelab.se/researcher/28dc0f841c0148c59291a83c4ffe1a78.json"}}, {"family": "Salfati", "given": "Elias", "initials": "E"}, {"family": "Zhao", "given": "Xiaoping", "initials": "X"}, {"family": "Braun", "given": "Kim Valeska Emilie", "initials": "KVE", "orcid": "0000-0001-8738-4139", "researcher": {"href": "https://publications.scilifelab.se/researcher/b0966cb600ed4c749be09388bb798d8d.json"}}, {"family": "Do", "given": "Anh Nguyet", "initials": "AN"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0001-5413-204X", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b9eaa6a5dfc4ecf8bf82ece793cd457.json"}}, {"family": "Zhang", "given": "Tao", "initials": "T"}, {"family": "Carnero-Montoro", "given": "Elena", "initials": "E", "orcid": "0000-0002-1947-9627", "researcher": {"href": "https://publications.scilifelab.se/researcher/87403846db104d3c9e4283dd00065da3.json"}}, {"family": "Shen", "given": "Jincheng", "initials": "J"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e137fc0192e4fa295a88589d57e3498.json"}}, {"family": "Montasser", "given": "May E", "initials": "ME"}, {"family": "O'Connell", "given": "Jeff R", "initials": "JR"}, {"family": "Yao", "given": "Chen", "initials": "C", "orcid": "0000-0002-3944-7788", "researcher": {"href": "https://publications.scilifelab.se/researcher/8d1a3603e21e4d52a4648eef4b86d3f8.json"}}, {"family": "Xia", "given": "Rui", "initials": "R"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Grove", "given": "Megan", "initials": "M"}, {"family": "Guan", "given": "Weihua", "initials": "W"}, {"family": "Liliane", "given": "Pfeiffer", "initials": "P"}, {"family": "Singmann", "given": "Paula", "initials": "P", "orcid": "0000-0003-2109-9970", "researcher": {"href": "https://publications.scilifelab.se/researcher/db716a10b55f4e57af04c01c5e8007d7.json"}}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M", "orcid": "0000-0003-3793-5910", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d21299bb41343f88142255e64a9da57.json"}}, {"family": "Meitinger", "given": "Thomas", "initials": "T"}, {"family": "Gieger", "given": "Christian", "initials": "C"}, {"family": "Peters", "given": "Annette", "initials": "A", "orcid": "0000-0001-6645-0985", "researcher": {"href": "https://publications.scilifelab.se/researcher/05465e52a0f6412e81752d2249af30de.json"}}, {"family": "Zhao", "given": "Wei", "initials": "W", "orcid": "0000-0001-7388-0692", "researcher": {"href": "https://publications.scilifelab.se/researcher/a0c2246e69494086bab7ead8e6f1f717.json"}}, {"family": "Ware", "given": "Erin B", "initials": "EB", "orcid": "0000-0003-4731-8158", "researcher": {"href": "https://publications.scilifelab.se/researcher/675e10a2b27a4f4b9de0ee766c4907dc.json"}}, {"family": "Smith", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0002-3575-5468", "researcher": {"href": "https://publications.scilifelab.se/researcher/311c7381092b4143bcd2e4ef93250526.json"}}, {"family": "Dhana", "given": "Klodian", "initials": "K"}, {"family": "van Meurs", "given": "Joyce", "initials": "J"}, {"family": "Uitterlinden", "given": "Andre", "initials": "A", "orcid": "0000-0002-7276-3387", "researcher": {"href": "https://publications.scilifelab.se/researcher/273577b238854023a9dffe34dabc3551.json"}}, {"family": "Ikram", "given": "Mohammad Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": "https://publications.scilifelab.se/researcher/2ec81571f4a94af682b4e23526f87385.json"}}, {"family": "Ghanbari", "given": "Mohsen", "initials": "M", "orcid": "0000-0002-9476-7143", "researcher": {"href": "https://publications.scilifelab.se/researcher/52ef9606de1144c994e0e854c5a85569.json"}}, {"family": "Zhi", "given": "Deugi", "initials": "D"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S", "orcid": "0000-0001-5894-0351", "researcher": {"href": "https://publications.scilifelab.se/researcher/9a0552f8a6514baa9bdb6809148aaddc.json"}}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Li", "given": "Shengxu", "initials": "S"}, {"family": "Sun", "given": "Dianjianyi", "initials": "D"}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications.scilifelab.se/researcher/9b3b149961364ccbb448a8cc3cdd6687.json"}}, {"family": "Chen", "given": "Yii-der Ida", "initials": "YI"}, {"family": "Damcott", "given": "Coleen", "initials": "C", "orcid": "0000-0001-6233-7395", "researcher": {"href": "https://publications.scilifelab.se/researcher/234acf5657cd4ede95641ee045cb23cd.json"}}, {"family": "Shuldiner", "given": "Alan R", "initials": "AR"}, {"family": "Absher", "given": "Devin M", "initials": "DM"}, {"family": "Horvath", "given": "Steve", "initials": "S", "orcid": "0000-0002-4110-3589", "researcher": {"href": "https://publications.scilifelab.se/researcher/d9fd917cfb8e43329e4dadb4e14e32ef.json"}}, {"family": "Tsao", "given": "Philip S", "initials": "PS", "orcid": "0000-0001-7274-9318", "researcher": {"href": "https://publications.scilifelab.se/researcher/1520706d352e454688b0a737b5d590ef.json"}}, {"family": "Kardia", "given": "Sharon", "initials": "S"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}, {"family": "Bell", "given": "Jordana T", "initials": "JT", "orcid": "0000-0002-3858-5986", "researcher": {"href": "https://publications.scilifelab.se/researcher/078c46640d7946ed9ed4e08e9f9a71fa.json"}}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Chen", "given": "Wei", "initials": "W", "orcid": "0000-0003-1566-7943", "researcher": {"href": "https://publications.scilifelab.se/researcher/905609ccc3704af9afccd0b9ab0553bf.json"}}, {"family": "Dehghan", "given": "Abbas", "initials": "A"}, {"family": "Arnett", "given": "Donna K", "initials": "DK", "orcid": "0000-0003-2219-657X", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1d283344e5c4e7daf4ff1a3709ba492.json"}}, {"family": "Waldenberger", "given": "Melanie", "initials": "M", "orcid": "0000-0003-0583-5093", "researcher": {"href": "https://publications.scilifelab.se/researcher/c8de22214f2448c6a7f86fc1040d0104.json"}}, {"family": "Hou", "given": "Lifang", "initials": "L"}, {"family": "Whitsel", "given": "Eric A", "initials": "EA"}, {"family": "Baccarelli", "given": "Andrea", "initials": "A"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications.scilifelab.se/researcher/b5de431c325e40f4adfe13c06cf1e0b9.json"}}, {"family": "Irvin", "given": "Marguerite R", "initials": "MR"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL", "orcid": "0000-0003-2349-0009", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e155ca3dd01486580be888d1ded405c.json"}}], "type": "journal article", "published": "2021-06-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "12", "issue": "1", "pages": "3987"}, "abstract": "Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.", "doi": "10.1038/s41467-021-23899-y", "pmid": "34183656", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41467-021-23899-y"}, {"db": "pmc", "key": "PMC8238961"}, {"db": "Dryad", "key": "10.5061/dryad.qfttdz0d8"}], "notes": [], "created": "2021-08-19T13:41:35.464Z", "modified": "2021-12-07T13:25:44.149Z"}]}