{"entity": "researcher", "timestamp": "2026-08-10T13:48:21.918Z", "family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "affiliations": ["Division of Immunology and Allergy, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/29721279f6fb4c50a2f96d86a0ce9686.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/29721279f6fb4c50a2f96d86a0ce9686"}}, "publications": [{"entity": "publication", "iuid": "579194408fda4d8c9e4324e8a98dd4e1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/579194408fda4d8c9e4324e8a98dd4e1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/579194408fda4d8c9e4324e8a98dd4e1"}}, "title": "Delayed generation of functional virus-specific circulating T follicular helper cells correlates with severe COVID-19.", "authors": [{"family": "Yu", "given": "Meng", "initials": "M", "orcid": "0000-0002-9798-6624", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e0d4b3b53994166af0f2f7fd0679c6b.json"}}, {"family": "Charles", "given": "Afandi", "initials": "A", "orcid": "0000-0003-0022-3303", "researcher": {"href": "https://publications.scilifelab.se/researcher/29721279f6fb4c50a2f96d86a0ce9686.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/38fe3a44fdb547b885cce5b6f490b2bc.json"}}, {"family": "\u00d6sterberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Falck-Jones", "given": "Sara", "initials": "S"}, {"family": "Azizmohammadi", "given": "Lida", "initials": "L"}, {"family": "\u00c5hlberg", "given": "Eric", "initials": "E"}, {"family": "Falck-Jones", "given": "Ryan", "initials": "R", "orcid": "0000-0002-0985-8658", "researcher": {"href": "https://publications.scilifelab.se/researcher/addfd2bdc37b4f7cb7bf4cb65183b153.json"}}, {"family": "Svensson", "given": "Julia", "initials": "J"}, {"family": "Nie", "given": "Mu", "initials": "M"}, {"family": "Warnqvist", "given": "Anna", "initials": "A"}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2e93a7400934289947153f095273178.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Lindgren", "given": "Gustaf", "initials": "G"}, {"family": "Lin", "given": "Ang", "initials": "A"}, {"family": "Maecker", "given": "Holden", "initials": "H", "orcid": "0000-0003-0795-9946", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3bcc923a42f4137a30d6ba7cb850d7f.json"}}, {"family": "Bell", "given": "Max", "initials": "M", "orcid": "0000-0001-7464-0324", "researcher": {"href": "https://publications.scilifelab.se/researcher/4bf2fb404fae432aa21aa9eb34098efc.json"}}, {"family": "Johansson", "given": "Niclas", "initials": "N"}, {"family": "Albert", "given": "Jan", "initials": "J", "orcid": "0000-0001-9020-0521", "researcher": {"href": "https://publications.scilifelab.se/researcher/d23f55d392eb411d90a53c2fb22aced3.json"}}, {"family": "Sundling", "given": "Christopher", "initials": "C", "orcid": "0000-0002-6138-690X", "researcher": {"href": "https://publications.scilifelab.se/researcher/89c1e689a46b4b14adb0dc99e1c0a58c.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "F\u00e4rnert", "given": "Anna", "initials": "A"}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}, {"family": "Smed-S\u00f6rensen", "given": "Anna", "initials": "A", "orcid": "0000-0001-6966-7039", "researcher": {"href": "https://publications.scilifelab.se/researcher/b874ce1e1fd4455e9d681c3d3db74ed0.json"}}], "type": "journal article", "published": "2023-04-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "14", "issue": "1", "pages": "2164"}, "abstract": "Effective humoral immune responses require well-orchestrated B and T follicular helper (Tfh) cell interactions. Whether these interactions are impaired and associated with COVID-19 disease severity is unclear. Here, longitudinal blood samples across COVID-19 disease severity are analysed. We find that during acute infection SARS-CoV-2-specific circulating Tfh (cTfh) cells expand with disease severity. SARS-CoV-2-specific cTfh cell frequencies correlate with plasmablast frequencies and SARS-CoV-2 antibody titers, avidity and neutralization. Furthermore, cTfh cells but not other memory CD4 T cells, from severe patients better induce plasmablast differentiation and antibody production compared to cTfh cells from mild patients. However, virus-specific cTfh cell development is delayed in patients that display or later develop severe disease compared to those with mild disease, which correlates with delayed induction of high-avidity neutralizing antibodies. Our study suggests that impaired generation of functional virus-specific cTfh cells delays high-quality antibody production at an early stage, potentially enabling progression to severe disease.", "doi": "10.1038/s41467-023-37835-9", "pmid": "37061513", "labels": {"Bioinformatics Long-term Support WABI": "Collaborative", "Bioinformatics Support, Infrastructure and Training": "Collaborative", "Bioinformatics (NBIS)": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC10105364"}, {"db": "pii", "key": "10.1038/s41467-023-37835-9"}], "notes": [], "created": "2023-04-21T13:16:11.901Z", "modified": "2023-11-16T14:36:19.050Z"}]}