{"entity": "researcher", "timestamp": "2026-07-20T13:21:19.171Z", "family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "affiliations": ["C\u00daRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland.", "Department of Medical Surgery and Health Science, University of Trieste, Trieste, Italy."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3"}}, "publications": [{"entity": "publication", "iuid": "1e5708bc6c1c4c099e773f1d29e68641", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1e5708bc6c1c4c099e773f1d29e68641.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1e5708bc6c1c4c099e773f1d29e68641"}}, "title": "Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis.", "authors": [{"family": "Thomas", "given": "Olivia G", "initials": "OG", "orcid": "0000-0002-2011-1344", "researcher": {"href": "https://publications.scilifelab.se/researcher/ea07f812ffee4db893c6f98548563525.json"}}, {"family": "Rykaczewska", "given": "Urszula", "initials": "U"}, {"family": "Gale\u0161i\u0107", "given": "Marina", "initials": "M"}, {"family": "van der Burgt", "given": "Rianne T M", "initials": "RTM"}, {"family": "Hall\u00e9n", "given": "Nils", "initials": "N"}, {"family": "Ferro", "given": "Filippo", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3.json"}}, {"family": "Bronge", "given": "Mattias", "initials": "M", "orcid": "0000-0002-1258-3982", "researcher": {"href": "https://publications.scilifelab.se/researcher/691b77352a57408896ef1fb486980ccd.json"}}, {"family": "Marti", "given": "Zoe", "initials": "Z"}, {"family": "Li", "given": "Yue", "initials": "Y"}, {"family": "Riqu\u00e9", "given": "Alexandra Hill", "initials": "AH"}, {"family": "Lin", "given": "Jianing", "initials": "J"}, {"family": "Krstic", "given": "Aleksa", "initials": "A"}, {"family": "Gromadzka", "given": "Alicja", "initials": "A"}, {"family": "Szonder", "given": "Andr\u00e1s Levente", "initials": "AL"}, {"family": "Sorini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-6803-8377", "researcher": {"href": "https://publications.scilifelab.se/researcher/975173f37f144f06b236817e224de7f0.json"}}, {"family": "Reina-Campos", "given": "Mar\u00eda", "initials": "M"}, {"family": "Sun", "given": "Ting", "initials": "T", "orcid": "0000-0002-7104-7215", "researcher": {"href": "https://publications.scilifelab.se/researcher/521fca43267242fca06da0f5fc823e6a.json"}}, {"family": "Rubio Rodr\u00edguez-Kirby", "given": "Leslie A", "initials": "LA", "orcid": "0000-0003-4467-2661", "researcher": {"href": "https://publications.scilifelab.se/researcher/9790e215a63d40aa8fac497b537999f9.json"}}, {"family": "Dumral", "given": "\u00d6zge", "initials": "\u00d6", "orcid": "0000-0002-9980-2702", "researcher": {"href": "https://publications.scilifelab.se/researcher/8288edd47f70479e93e1fc441d486997.json"}}, {"family": "Berglund", "given": "Rasmus", "initials": "R"}, {"family": "Kakhki", "given": "Majid Pahlevan", "initials": "MP"}, {"family": "Adzemovic", "given": "Milena Z", "initials": "MZ"}, {"family": "Zeitelhofer", "given": "Manuel", "initials": "M"}, {"family": "Akpinar", "given": "Birce", "initials": "B"}, {"family": "Tengvall", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0424-3571", "researcher": {"href": "https://publications.scilifelab.se/researcher/59b02aaaf03b4cd39150c3034888c81d.json"}}, {"family": "Nilsson", "given": "Ola B", "initials": "OB", "orcid": "0000-0002-7516-1760", "researcher": {"href": "https://publications.scilifelab.se/researcher/096ce3bf888b4ad395d53bb3c11f6946.json"}}, {"family": "Holmgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-2656-1864", "researcher": {"href": "https://publications.scilifelab.se/researcher/6160949c45cf4daaab3991d051db5a16.json"}}, {"family": "Cucuzza", "given": "Chiara Starvaggi", "initials": "CS"}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA"}, {"family": "Gafvelin", "given": "Guro", "initials": "G", "orcid": "0000-0003-1618-4011", "researcher": {"href": "https://publications.scilifelab.se/researcher/870294f4604744ccb212a3c299887ecc.json"}}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Castelo-Branco", "given": "Gon\u00e7alo", "initials": "G", "orcid": "0000-0003-2247-9393", "researcher": {"href": "https://publications.scilifelab.se/researcher/10b1a8fb48114340b8e390ca1f9e3321.json"}}, {"family": "Needhamsen", "given": "Maria", "initials": "M"}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications.scilifelab.se/researcher/5446d6d754bc4c429d0e48ade419413c.json"}}, {"family": "Piehl", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-8329-5219", "researcher": {"href": "https://publications.scilifelab.se/researcher/ee04062fbee34836a4fa3f4d2e8076cd.json"}}, {"family": "Gr\u00e4slund", "given": "Torbj\u00f6rn", "initials": "T", "orcid": "0000-0002-5391-600X", "researcher": {"href": "https://publications.scilifelab.se/researcher/52adbc739e274652bbf877facf4f0959.json"}}, {"family": "Alfredsson", "given": "Lars", "initials": "L", "orcid": "0000-0003-1688-6697", "researcher": {"href": "https://publications.scilifelab.se/researcher/6df230614a8a448e8607e03480169658.json"}}, {"family": "Lund", "given": "Harald", "initials": "H", "orcid": "0000-0001-8046-0805", "researcher": {"href": "https://publications.scilifelab.se/researcher/4fe4902c355449e4812008d4ad7a37e0.json"}}, {"family": "Uhl\u00e9n", "given": "Per", "initials": "P", "orcid": "0000-0003-1446-1062", "researcher": {"href": "https://publications.scilifelab.se/researcher/91c3e953634140b8974186ac0d7eac85.json"}}, {"family": "Kockum", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0867-4726", "researcher": {"href": "https://publications.scilifelab.se/researcher/03ebcc6a01ef4d0db4e4673aff8de5d8.json"}}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Jagodic", "given": "Maja", "initials": "M", "orcid": "0000-0003-0756-889X", "researcher": {"href": "https://publications.scilifelab.se/researcher/b651ef39c6b0436992e2305f425eba72.json"}}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H", "orcid": "0000-0003-4882-7624", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e701613f60249b793f2def737168a05.json"}}, {"family": "Guerreiro-Cacais", "given": "Andr\u00e9 Ortlieb", "initials": "AO", "orcid": "0000-0002-4561-2823", "researcher": {"href": "https://publications.scilifelab.se/researcher/9b824181455243b19f4aa145a4545870.json"}}, {"family": "Olsson", "given": "Tomas", "initials": "T"}], "type": "journal article", "published": "2026-01-22", "journal": {"title": "Cell", "issn": "1097-4172", "issn-l": "0092-8674", "volume": "189", "issue": "2", "pages": "585-602.e38"}, "abstract": "Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with MS (pwMS). Here, we show that ANO2-specific CD4+ T cells are more frequent in pwMS. Immunization of SJL/J mice with ANO2 or EBNA1 led to cross-reactive CD4+ T cell and antibody responses. ANO2 pre-immunization led to exacerbated experimental autoimmune encephalomyelitis (EAE), an effect mediated by CD4+ T cells, as confirmed by adoptive transfer experiments. T cell clones with cross-reactivity to EBNA1 and ANO2 could be isolated from natalizumab-treated pwMS, and sequencing of EBNA1- and ANO2-specific T cell receptors (TCRs) revealed a significant repertoire overlap. We thus report the first mechanistic evidence that EBNA1 CD4+ T cells can target the MS autoantigen ANO2, thereby establishing a link between EBV infection and neuroinflammation.", "doi": "10.1016/j.cell.2025.12.032", "pmid": "41534529", "labels": {"Autoimmunity and Serology Profiling": "Service", "National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service"}, "xrefs": [{"db": "pii", "key": "S0092-8674(25)01481-3"}], "notes": [], "created": "2026-01-15T20:23:02.729Z", "modified": "2026-03-24T09:17:16.086Z"}, {"entity": "publication", "iuid": "bad5b686c16e48c0a5d5984892016a93", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bad5b686c16e48c0a5d5984892016a93.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bad5b686c16e48c0a5d5984892016a93"}}, "title": "Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model.", "authors": [{"family": "Contessotto", "given": "Paolo", "initials": "P", "orcid": "0000-0002-6990-9883", "researcher": {"href": "https://publications.scilifelab.se/researcher/cd9eff0e573f4f7097fb575bf6479f8e.json"}}, {"family": "Spelat", "given": "Renza", "initials": "R", "orcid": "0000-0001-5794-8976", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7974e486fb24bbf979eb920f9d49380.json"}}, {"family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3.json"}}, {"family": "Vysockas", "given": "Vaidas", "initials": "V", "orcid": "0000-0002-2179-2348", "researcher": {"href": "https://publications.scilifelab.se/researcher/0c01194476544942a0fd0c153a44487e.json"}}, {"family": "Krivickien\u0117", "given": "Au\u0161ra", "initials": "A", "orcid": "0000-0003-4978-2915", "researcher": {"href": "https://publications.scilifelab.se/researcher/29901a96314b4fc489e3aa1712004ae7.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications.scilifelab.se/researcher/458804f3f7274b8a9efe7a90469d0e56.json"}}, {"family": "Chantepie", "given": "Sandrine", "initials": "S"}, {"family": "Chinello", "given": "Clizia", "initials": "C"}, {"family": "Pauza", "given": "Audrys G", "initials": "AG", "orcid": "0000-0001-9635-8872", "researcher": {"href": "https://publications.scilifelab.se/researcher/cb08209745534c21878f607cc414aab8.json"}}, {"family": "Valente", "given": "Camilla", "initials": "C", "orcid": "0000-0003-3084-1102", "researcher": {"href": "https://publications.scilifelab.se/researcher/7cf678853015478daf234ab0f854584e.json"}}, {"family": "Rackauskas", "given": "Mindaugas", "initials": "M", "orcid": "0000-0002-2503-3437", "researcher": {"href": "https://publications.scilifelab.se/researcher/d2edbecde7f94bcfbea7f0776b69bbb2.json"}}, {"family": "Casara", "given": "Alvise", "initials": "A", "orcid": "0000-0002-5056-8732", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3bfb0f2394e44cda5c96d23c6c3b32e.json"}}, {"family": "Zigmantait\u0117", "given": "Vilma", "initials": "V", "orcid": "0000-0002-0410-1533", "researcher": {"href": "https://publications.scilifelab.se/researcher/baa4c86fec6e4f0bbdd6e980a9796ff6.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F", "orcid": "0000-0002-8663-0374", "researcher": {"href": "https://publications.scilifelab.se/researcher/3d2bb884997b4437924cc2659b823637.json"}}, {"family": "Papy-Garcia", "given": "Dulce", "initials": "D", "orcid": "0000-0003-2225-9331", "researcher": {"href": "https://publications.scilifelab.se/researcher/697039fd70604a79804beb2e8179d9cf.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications.scilifelab.se/researcher/62e0b7440ff1447c9611d938d185fbc7.json"}}, {"family": "Ereminien\u0117", "given": "Egl\u0117", "initials": "E", "orcid": "0000-0002-8332-788X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8ab7bba2798e40f3b67a791e6be512bc.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A"}, {"family": "Da Costa", "given": "Mark", "initials": "M", "orcid": "0000-0001-7713-2608", "researcher": {"href": "https://publications.scilifelab.se/researcher/a18320fbed7b43299aedc829736f4eb9.json"}}], "type": "journal article", "published": "2023-02-22", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "995", "issn-l": "2041-1723"}, "abstract": "The rising incidence of non-ST-segment elevation myocardial infarction (NSTEMI) and associated long-term high mortality constitutes an urgent clinical issue. Unfortunately, the study of possible interventions to treat this pathology lacks a reproducible pre-clinical model. Indeed, currently adopted small and large animal models of MI mimic only full-thickness, ST-segment-elevation (STEMI) infarcts, and hence cater only for an investigation into therapeutics and interventions directed at this subset of MI. Thus, we develop an ovine model of NSTEMI by ligating the myocardial muscle at precise intervals parallel to the left anterior descending coronary artery. Upon histological and functional investigation to validate the proposed model and comparison with STEMI full ligation model, RNA-seq and proteomics show the distinctive features of post-NSTEMI tissue remodelling. Transcriptome and proteome-derived pathway analyses at acute (7 days) and late (28 days) post-NSTEMI pinpoint specific alterations in cardiac post-ischaemic extracellular matrix. Together with the rise of well-known markers of inflammation and fibrosis, NSTEMI ischaemic regions show distinctive patterns of complex galactosylated and sialylated N-glycans in cellular membranes and extracellular matrix. Identifying such changes in molecular moieties accessible to infusible and intra-myocardial injectable drugs sheds light on developing targeted pharmacological solutions to contrast adverse fibrotic remodelling.", "doi": "10.1038/s41467-023-36350-1", "pmid": "36813782", "labels": {"Glycoproteomics and MS Proteomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC9945840"}, {"db": "pii", "key": "10.1038/s41467-023-36350-1"}], "notes": [], "created": "2023-12-04T10:23:03.795Z", "modified": "2024-01-16T13:46:27.924Z"}, {"entity": "publication", "iuid": "b6538257193e4bda9387d19ec84faaa0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b6538257193e4bda9387d19ec84faaa0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b6538257193e4bda9387d19ec84faaa0"}}, "title": "Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration.", "authors": [{"family": "Spelat", "given": "Renza", "initials": "R", "orcid": "0000-0001-5794-8976", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7974e486fb24bbf979eb920f9d49380.json"}}, {"family": "Ferro", "given": "Federico", "initials": "F", "orcid": "0000-0002-6023-8227", "researcher": {"href": "https://publications.scilifelab.se/researcher/27810903638948feb4391fa537a7eda3.json"}}, {"family": "Contessotto", "given": "Paolo", "initials": "P"}, {"family": "Aljaabary", "given": "Amal", "initials": "A", "orcid": "0000-0003-0361-166X", "researcher": {"href": "https://publications.scilifelab.se/researcher/af820e3a3c8f441c9ed519c8849f163d.json"}}, {"family": "Martin-Salda\u00f1a", "given": "Sergio", "initials": "S", "orcid": "0000-0002-9506-8483", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7a4a6088c0a4597b6c18c2a48c74b7a.json"}}, {"family": "Jin", "given": "Chunsheng", "initials": "C", "orcid": "0000-0002-0229-102X", "researcher": {"href": "https://publications.scilifelab.se/researcher/458804f3f7274b8a9efe7a90469d0e56.json"}}, {"family": "Karlsson", "given": "Niclas G", "initials": "NG", "orcid": "0000-0002-3045-2628", "researcher": {"href": "https://publications.scilifelab.se/researcher/62e0b7440ff1447c9611d938d185fbc7.json"}}, {"family": "Grealy", "given": "Maura", "initials": "M"}, {"family": "Hilscher", "given": "Markus M", "initials": "MM", "orcid": "0000-0001-7782-0830", "researcher": {"href": "https://publications.scilifelab.se/researcher/1de5317c53f34bc89dabfddb0be44983.json"}}, {"family": "Magni", "given": "Fulvio", "initials": "F"}, {"family": "Chinello", "given": "Clizia", "initials": "C"}, {"family": "Kilcoyne", "given": "Michelle", "initials": "M", "orcid": "0000-0002-8870-1308", "researcher": {"href": "https://publications.scilifelab.se/researcher/d1d1606f98e540fbb09f7251adf921a2.json"}}, {"family": "Pandit", "given": "Abhay", "initials": "A", "orcid": "0000-0002-6292-4933", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4611c209a394949bd971c8b12692fac.json"}}], "type": "journal article", "published": "2022-12-13", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "5", "issue": "1", "pages": "1365", "issn-l": "2399-3642"}, "abstract": "The ability of the zebrafish heart to regenerate following injury makes it a valuable model to deduce why this capability in mammals is limited to early neonatal stages. Although metabolic reprogramming and glycosylation remodeling have emerged as key aspects in many biological processes, how they may trigger a cardiac regenerative response in zebrafish is still a crucial question. Here, by using an up-to-date panel of transcriptomic, proteomic and glycomic approaches, we identify a metabolic switch from mitochondrial oxidative phosphorylation to glycolysis associated with membrane glycosylation remodeling during heart regeneration. Importantly, we establish the N- and O-linked glycan structural repertoire of the regenerating zebrafish heart, and link alterations in both sialylation and high mannose structures across the phases of regeneration. Our results show that metabolic reprogramming and glycan structural remodeling are potential drivers of tissue regeneration after cardiac injury, providing the biological rationale to develop novel therapeutics to elicit heart regeneration in mammals.", "doi": "10.1038/s42003-022-04328-2", "pmid": "36509839", "labels": {"In Situ Sequencing": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9744865"}, {"db": "pii", "key": "10.1038/s42003-022-04328-2"}], "notes": [], "created": "2023-05-31T10:56:03.689Z", "modified": "2025-10-17T13:02:17.158Z"}]}