{"entity": "researcher", "timestamp": "2026-08-07T19:07:47.776Z", "family": "Svedberg", "given": "Jesper", "initials": "J", "orcid": "0000-0002-0951-3019", "affiliations": ["Department of Organismal Biology, Evolutionary Biology Centre (EBC), Uppsala University, 752 36 Uppsala, Sweden; jsvedberg@gmail.com hanna.johannesson@ebc.uu.se.", "Department of Biomolecular Engineering, University of California, Santa Cruz, CA 95064."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/1d35216730c841d197a958bfa00a06a0.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/1d35216730c841d197a958bfa00a06a0"}}, "publications": [{"entity": "publication", "iuid": "2cea4b166b6140d9959d018dcb7952da", "links": {"self": {"href": "https://publications.scilifelab.se/publication/2cea4b166b6140d9959d018dcb7952da.json"}, "display": {"href": "https://publications.scilifelab.se/publication/2cea4b166b6140d9959d018dcb7952da"}}, "title": "Meiotic drive is associated with sexual incompatibility in Neurospora.", "authors": [{"family": "Vogan", "given": "Aaron A", "initials": "AA", "orcid": "0000-0003-2013-7445", "researcher": {"href": "https://publications.scilifelab.se/researcher/71c6d460e3b44712a1a9dc19066211a4.json"}}, {"family": "Svedberg", "given": "Jesper", "initials": "J", "orcid": "0000-0002-0951-3019", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d35216730c841d197a958bfa00a06a0.json"}}, {"family": "Grudzinska-Sterno", "given": "Magdalena", "initials": "M"}, {"family": "Johannesson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-6359-9856", "researcher": {"href": "https://publications.scilifelab.se/researcher/36e8fe278e01470e8cddaaccc5dad596.json"}}], "type": "journal article", "published": "2022-09-23", "journal": {"title": "Evolution", "issn": "1558-5646", "issn-l": "0014-3820"}, "abstract": "Evolution of Bateson-Dobzhansky-Muller (BDM) incompatibilities is thought to represent a key step in the formation of separate species. They are incompatible alleles that have evolved in separate populations and are exposed in hybrid offspring as hybrid sterility or lethality. In this study, we reveal a previously unconsidered mechanism promoting the formation of BDM incompatibilities, meiotic drive. Theoretical studies have evaluated the role that meiotic drive, the phenomenon whereby selfish elements bias their transmission to progeny at ratios above 50:50, plays in speciation, and have mostly concluded that drive could not result in speciation on its own. Using the model fungus Neurospora, we demonstrate that the large meiotic drive haplotypes, Sk-2 and Sk-3, contain putative sexual incompatibilities. Our experiments revealed that although crosses between Neurospora intermedia and Neurospora metzenbergii produce viable progeny at appreciable rates, when strains of N. intermedia carry Sk-2 or Sk-3 the proportion of viable progeny drops substantially. Additionally, it appears that Sk-2 and Sk-3 have accumulated different incompatibility phenotypes, consistent with their independent evolutionary history. This research illustrates how meiotic drive can contribute to reproductive isolation between populations, and thereby speciation.", "doi": "10.1111/evo.14630", "pmid": "36148939", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [], "notes": [], "created": "2022-11-09T15:40:35.685Z", "modified": "2024-01-16T13:48:34.990Z"}, {"entity": "publication", "iuid": "86f05d7bca134d87b5dd15cffe3d55dd", "links": {"self": {"href": "https://publications.scilifelab.se/publication/86f05d7bca134d87b5dd15cffe3d55dd.json"}, "display": {"href": "https://publications.scilifelab.se/publication/86f05d7bca134d87b5dd15cffe3d55dd"}}, "title": "An introgressed gene causes meiotic drive in Neurospora sitophila.", "authors": [{"family": "Svedberg", "given": "Jesper", "initials": "J", "orcid": "0000-0002-0951-3019", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d35216730c841d197a958bfa00a06a0.json"}}, {"family": "Vogan", "given": "Aaron A", "initials": "AA"}, {"family": "Rhoades", "given": "Nicholas A", "initials": "NA"}, {"family": "Sarmarajeewa", "given": "Dilini", "initials": "D"}, {"family": "Jacobson", "given": "David J", "initials": "DJ"}, {"family": "Lascoux", "given": "Martin", "initials": "M", "orcid": "0000-0003-1699-9042", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ad3fadfb69448f397ad3bf55b2d2cb3.json"}}, {"family": "Hammond", "given": "Thomas M", "initials": "TM", "orcid": "0000-0002-0812-4759", "researcher": {"href": "https://publications.scilifelab.se/researcher/cdc694cc4c4749ca821feadf727fe77b.json"}}, {"family": "Johannesson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-6359-9856", "researcher": {"href": "https://publications.scilifelab.se/researcher/36e8fe278e01470e8cddaaccc5dad596.json"}}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "17", "pages": "e2026605118", "issn-l": "0027-8424"}, "abstract": "Meiotic drive elements cause their own preferential transmission following meiosis. In fungi, this phenomenon takes the shape of spore killing, and in the filamentous ascomycete Neurospora sitophila, the Sk-1 spore killer element is found in many natural populations. In this study, we identify the gene responsible for spore killing in Sk-1 by generating both long- and short-read genomic data and by using these data to perform a genome-wide association test. We name this gene Spk-1 Through molecular dissection, we show that a single 405-nt-long open reading frame generates a product that both acts as a poison capable of killing sibling spores and as an antidote that rescues spores that produce it. By phylogenetic analysis, we demonstrate that the gene has likely been introgressed from the closely related species Neurospora hispaniola, and we identify three subclades of N. sitophila, one where Sk-1 is fixed, another where Sk-1 is absent, and a third where both killer and sensitive strain are found. Finally, we show that spore killing can be suppressed through an RNA interference-based genome defense pathway known as meiotic silencing by unpaired DNA. Spk-1 is not related to other known meiotic drive genes, and similar sequences are only found within Neurospora These results shed light on the diversity of genes capable of causing meiotic drive, their origin and evolution, and their interaction with the host genome.", "doi": "10.1073/pnas.2026605118", "pmid": "33875604", "labels": {"National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pii", "key": "2026605118"}, {"db": "pmc", "key": "PMC8092558"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.5093585.v1"}], "notes": [], "created": "2021-06-01T20:57:22.667Z", "modified": "2024-01-16T13:48:39.983Z"}]}