{"entity": "researcher", "timestamp": "2026-07-12T17:55:06.868Z", "family": "Petkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-8052-9646", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6"}}, "publications": [{"entity": "publication", "iuid": "b84279382a5043ffaca48ac41a3531be", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b84279382a5043ffaca48ac41a3531be.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b84279382a5043ffaca48ac41a3531be"}}, "title": "Proteomic Analysis of Mucosal and Systemic Responses to SARS-CoV-2 Antigen.", "authors": [{"family": "Martinson", "given": "Neil", "initials": "N"}, {"family": "Gordhan", "given": "Bhavna", "initials": "B"}, {"family": "Petkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-8052-9646", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6.json"}}, {"family": "Pillay", "given": "Azure-Dee", "initials": "A"}, {"family": "Seiphetlo", "given": "Thabiso", "initials": "T"}, {"family": "Singh", "given": "Natasha", "initials": "N"}, {"family": "Otwombe", "given": "Kennedy", "initials": "K", "orcid": "0000-0002-7433-4383", "researcher": {"href": "https://publications.scilifelab.se/researcher/e11f7013a65d42eba2f8ecdb19e758f3.json"}}, {"family": "Lebina", "given": "Limakatso", "initials": "L"}, {"family": "Fredolini", "given": "Claudia", "initials": "C"}, {"family": "Chiodi", "given": "Francesca", "initials": "F", "orcid": "0000-0002-1385-8343", "researcher": {"href": "https://publications.scilifelab.se/researcher/c83e956e7a5840939e80840c40bdc636.json"}}, {"family": "Fox", "given": "Julie", "initials": "J", "orcid": "0000-0002-0583-8019", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c0c9138a8b84098a631234f3ea8458c.json"}}, {"family": "Kana", "given": "Bavesh", "initials": "B"}, {"family": "Herrera", "given": "Carolina", "initials": "C", "orcid": "0000-0003-3701-752X", "researcher": {"href": "https://publications.scilifelab.se/researcher/129f316fb11c44b89ff3774d92ab9be2.json"}}], "type": "journal article", "published": "2023-02-02", "journal": {"title": "Vaccines (Basel)", "issn": "2076-393X", "issn-l": null, "volume": "11", "issue": "2", "pages": null}, "abstract": "The mucosal environment of the upper respiratory tract is the first barrier of protection against SARS-CoV-2 transmission. However, the mucosal factors involved in viral transmission and potentially modulating the capacity to prevent such transmission have not fully been identified. In this pilot proteomics study, we compared mucosal and systemic compartments in a South African cohort of vaccinated and unvaccinated individuals undergoing maxillofacial surgery with previous history of COVID-19 or not. Inflammatory profiles were analyzed in plasma, nasopharyngeal swabs, and nasal and oral tissue explant cultures, using Olink and Luminex technologies. SARS-CoV-2-specific antibody levels were measured in serum and tissue explants. An increased pro-inflammatory proteomic profile was measured in the nasal compartment compared to plasma. However, IP-10 and MIG levels were higher in secretions than in nasal tissue, and the opposite was observed for TGF-\u03b2. Nasal anti-SARS-CoV-2 spike IgG correlated with mucosal MIG expression for all participants. A further positive correlation was found with IP-10 in BioNTech/Pfizer-vaccinated individuals. Systemic levels of anti-SARS-CoV-2 spike IgG elicited by this vaccine correlated with plasma IL-10, IL-6 and HBD4. Proteomic profiles measured in mucosal tissues and secretions using combined technologies could reveal correlates of protection at the mucosal portals of viral entry.", "doi": "10.3390/vaccines11020334", "pmid": "36851212", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "vaccines11020334"}], "notes": [], "created": "2023-02-28T14:33:56.186Z", "modified": "2023-02-28T14:34:53.058Z"}, {"entity": "publication", "iuid": "6aea5c20a9e349c5b122a112cf62160d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/6aea5c20a9e349c5b122a112cf62160d"}}, "title": "Profiling of Inflammatory Proteins in Plasma of HIV-1-Infected Children Receiving Antiretroviral Therapy.", "authors": [{"family": "Lemma", "given": "Mahlet", "initials": "M"}, {"family": "Petkov", "given": "Stefan", "initials": "S", "orcid": "0000-0002-8052-9646", "researcher": {"href": "https://publications.scilifelab.se/researcher/1c9fba3bf1ab4f60beac9bc5581f12f6.json"}}, {"family": "Bekele", "given": "Yonas", "initials": "Y"}, {"family": "Petros", "given": "Beyene", "initials": "B"}, {"family": "Howe", "given": "Rawleigh", "initials": "R"}, {"family": "Chiodi", "given": "Francesca", "initials": "F"}], "type": "journal article", "published": "2020-09-07", "journal": {"title": "Proteomes", "issn": "2227-7382", "volume": "8", "issue": "3", "pages": "24", "issn-l": "2227-7382"}, "abstract": "Treatment of HIV-1-infected patients results in improved clinical and immunological conditions, but severe non-AIDS-related conditions still persist. Novel proteomic platforms have identified inflammatory proteins where abundance is dysregulated in adult treated patients, whereas limited data are available in treated HIV-1 infection of children. Using a proteomic plasma profiling approach comprising 92 inflammation-related molecules, we analyzed specimens from 43 vertically HIV-1-infected children receiving antiretroviral treatment (ART) and matched controls in Ethiopia. The infected children were analyzed as a group and separately, according to age of treatment initiation. Proteins displaying a significantly different abundance between groups were hierarchically clustered and presented in heat maps. Random forest analysis was performed to pin-point proteins discriminating between groups; five proteins (STAMBP, CD5, TFG-\u03b1, TRANCE, AXIN1) were the strongest prediction factors for treated HIV-1 infection. TRANCE was previously linked to reduced bone mass levels in HIV-1-infected children. CCL4 chemokine, ligand to HIV-1 co-receptor CCR5, was the most critical protein for successful classification between children who initiated ART at different time points. Our data provide evidence that a dysregulated expression of proteins linked to immunological abnormalities and bone metabolism can be found in HIV-1-infected children with prolonged exposure to ART.", "doi": "10.3390/proteomes8030024", "pmid": "32906648", "labels": {"Affinity Proteomics Stockholm": "Service"}, "xrefs": [{"db": "pii", "key": "proteomes8030024"}, {"db": "pmc", "key": "PMC7563605"}], "notes": [], "created": "2020-12-10T16:30:02.494Z", "modified": "2021-11-10T12:47:23.760Z"}]}