{"entity": "researcher", "timestamp": "2026-08-17T01:42:30.208Z", "family": "Bergstedt", "given": "Jacob", "initials": "J", "orcid": "0000-0002-9279-6936", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0e8ca729357b421588628aa2eb06c2f8.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0e8ca729357b421588628aa2eb06c2f8"}}, "publications": [{"entity": "publication", "iuid": "dd0afad963a94899b6d550a9f7f21965", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dd0afad963a94899b6d550a9f7f21965.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dd0afad963a94899b6d550a9f7f21965"}}, "title": "An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder.", "authors": [{"family": "Pasman", "given": "Jo\u00eblle A", "initials": "JA", "orcid": "0000-0001-7558-0482", "researcher": {"href": "https://publications.scilifelab.se/researcher/1bb78c586bfc443b92436572de80cb90.json"}}, {"family": "Bergstedt", "given": "Jacob", "initials": "J", "orcid": "0000-0002-9279-6936", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e8ca729357b421588628aa2eb06c2f8.json"}}, {"family": "Harder", "given": "Arvid", "initials": "A"}, {"family": "Gong", "given": "Tong", "initials": "T"}, {"family": "Xiong", "given": "Ying", "initials": "Y", "orcid": "0000-0001-7644-014X", "researcher": {"href": "https://publications.scilifelab.se/researcher/72484ccb61b140ca946294b68042c330.json"}}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ab8a681a053477b81f093cbd6232947.json"}}, {"family": "Treur", "given": "Jorien L", "initials": "JL"}, {"family": "Choi", "given": "Karmel W", "initials": "KW", "orcid": "0000-0002-3914-2431", "researcher": {"href": "https://publications.scilifelab.se/researcher/999aa3a1fbe943458b8db7c41bcc4965.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "Lu", "given": "Yi", "initials": "Y"}], "type": "journal article", "published": "2025-08-22", "journal": {"title": "Nat Ment Health", "issn": "2731-6076", "volume": "3", "issue": "9", "pages": "1002-1011", "issn-l": null}, "abstract": "Major depressive disorder (MDD) is a prevalent and debilitating disorder whose causes and consequences remain insufficiently understood. Genetic variants can be used to study causal relationships with other traits. Here we reviewed 201 MDD-associated traits and performed genetic correlation analyses for 115 traits, two-sample Mendelian randomization for 89 of them, and one-sample Mendelian randomization for an additional 43 outcomes, applying sensitivity tests and power analyses. We show that MDD liability increases risk for poorer circadian, cognitive, diet, medical disease, endocrine, functional, inflammatory, metabolic, mortality, physical activity, reproduction, risk behavior, social, socioeconomic and suicide outcomes. Most associations were bidirectional, although with weaker evidence for diet, disease and endocrine traits causing MDD risk. These findings provide a systematic overview of traits putatively causally linked to MDD-confirming known links and identifying new ones-and underscore MDD as a cross-cutting risk factor across medical, functional and psychosocial domains.", "doi": "10.1038/s44220-025-00471-x", "pmid": "40932904", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12417207"}, {"db": "pii", "key": "471"}], "notes": [], "created": "2025-11-28T10:48:08.055Z", "modified": "2025-11-28T10:48:08.228Z"}, {"entity": "publication", "iuid": "951fe1c92cc543a6a9e5e7e77d717e43", "links": {"self": {"href": "https://publications.scilifelab.se/publication/951fe1c92cc543a6a9e5e7e77d717e43.json"}, "display": {"href": "https://publications.scilifelab.se/publication/951fe1c92cc543a6a9e5e7e77d717e43"}}, "title": "Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.", "authors": [{"family": "Bergstedt", "given": "Jacob", "initials": "J", "orcid": "0000-0002-9279-6936", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e8ca729357b421588628aa2eb06c2f8.json"}}, {"family": "Pasman", "given": "Jo\u00eblle A", "initials": "JA"}, {"family": "Ma", "given": "Ziyan", "initials": "Z", "orcid": "0000-0002-7514-7934", "researcher": {"href": "https://publications.scilifelab.se/researcher/2bbd5464ee38451ca03fcaad9c139880.json"}}, {"family": "Harder", "given": "Arvid", "initials": "A"}, {"family": "Yao", "given": "Shuyang", "initials": "S", "orcid": "0000-0001-9669-4470", "researcher": {"href": "https://publications.scilifelab.se/researcher/fcd036ee020e4622ad16d020bfcd7b38.json"}}, {"family": "Parker", "given": "Nadine", "initials": "N", "orcid": "0000-0002-8369-0152", "researcher": {"href": "https://publications.scilifelab.se/researcher/75b520fd4bc844bbbe2a69cbb7add972.json"}}, {"family": "Treur", "given": "Jorien L", "initials": "JL"}, {"family": "Smit", "given": "Dirk J A", "initials": "DJA", "orcid": "0000-0001-8301-8860", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe64f7980537495aba79c0eca978e95d.json"}}, {"family": "Frei", "given": "Oleksandr", "initials": "O", "orcid": "0000-0002-6427-2625", "researcher": {"href": "https://publications.scilifelab.se/researcher/9c8807f848384cc6a2740d146982de78.json"}}, {"family": "Shadrin", "given": "Alexey A", "initials": "AA"}, {"family": "Meijsen", "given": "Joeri J", "initials": "JJ", "orcid": "0000-0002-4161-2199", "researcher": {"href": "https://publications.scilifelab.se/researcher/033902c73aa9444f849c849573020961.json"}}, {"family": "Shen", "given": "Qing", "initials": "Q"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S"}, {"family": "Tornvall", "given": "Per", "initials": "P"}, {"family": "Buil", "given": "Alfonso", "initials": "A", "orcid": "0000-0002-3097-1014", "researcher": {"href": "https://publications.scilifelab.se/researcher/84f11deb6b084f7fa476ea29893febd9.json"}}, {"family": "Werge", "given": "Thomas", "initials": "T", "orcid": "0000-0003-1829-0766", "researcher": {"href": "https://publications.scilifelab.se/researcher/89e727c9b54c4e23b9104fbc10b7b4e3.json"}}, {"family": "Hjerling-Leffler", "given": "Jens", "initials": "J", "orcid": "0000-0002-4539-1776", "researcher": {"href": "https://publications.scilifelab.se/researcher/51675f0ff9aa47d89d6b2eb84a14820a.json"}}, {"family": "Als", "given": "Thomas D", "initials": "TD", "orcid": "0000-0002-2963-1928", "researcher": {"href": "https://publications.scilifelab.se/researcher/099f1704a3c44f2882495f41a5124747.json"}}, {"family": "B\u00f8rglum", "given": "Anders D", "initials": "AD", "orcid": "0000-0001-8627-7219", "researcher": {"href": "https://publications.scilifelab.se/researcher/2165b6bc161443c5b670ef7d982b2e85.json"}}, {"family": "Lewis", "given": "Cathryn M", "initials": "CM", "orcid": "0000-0002-8249-8476", "researcher": {"href": "https://publications.scilifelab.se/researcher/72c89121dcde4b36a8d0e661ddc32b99.json"}}, {"family": "McIntosh", "given": "Andrew M", "initials": "AM", "orcid": "0000-0002-0198-4588", "researcher": {"href": "https://publications.scilifelab.se/researcher/cbac1cee97084746b97442ec39efe91b.json"}}, {"family": "Valdimarsd\u00f3ttir", "given": "Unnur A", "initials": "UA", "orcid": "0000-0001-5382-946X", "researcher": {"href": "https://publications.scilifelab.se/researcher/255c46fadd18490cbda4aef22474fbfb.json"}}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications.scilifelab.se/researcher/56f384e8e2fd4a7383c7b26e88a828b2.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF", "orcid": "0000-0002-6619-873X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4d95de0b5ab14586980a6a13c8299346.json"}}, {"family": "Lu", "given": "Yi", "initials": "Y", "orcid": "0000-0001-9933-3654", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a73eafe0b0e4221a77b96800883413d.json"}}, {"family": "Fang", "given": "Fang", "initials": "F", "orcid": "0000-0002-3310-6456", "researcher": {"href": "https://publications.scilifelab.se/researcher/5ab8a681a053477b81f093cbd6232947.json"}}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Nat Cardiovasc Res", "issn": "2731-0590", "volume": "3", "issue": "6", "pages": "754-769", "issn-l": null}, "abstract": "Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus. Part of the genetic overlap was explained by shared inflammatory, metabolic and psychosocial or lifestyle risk factors. Our data indicated causal effects of genetic liability to MDD on CVD risk, but not from most CVDs to MDD, and showed that the causal effects were partly explained by metabolic and psychosocial or lifestyle factors. The distinct signature of MDD-atherosclerotic CVD comorbidity suggests an immunometabolic subtype of MDD that is more strongly associated with CVD than overall MDD. In summary, we identified biological mechanisms underlying MDD-CVD comorbidity and modifiable risk factors for prevention of CVD in individuals with MDD.", "doi": "10.1038/s44161-024-00488-y", "pmid": "39215135", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "mid", "key": "NIHMS2040135"}, {"db": "pmc", "key": "PMC11182748"}, {"db": "pii", "key": "10.1038/s44161-024-00488-y"}], "notes": [], "created": "2025-02-28T14:16:32.184Z", "modified": "2025-12-04T19:40:53.954Z"}]}