{"entity": "researcher", "timestamp": "2026-08-13T18:51:03.570Z", "family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "affiliations": ["Division of Clinical Chemistry and Pharmacology, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden.", "Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Link\u00f6ping, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4"}}, "publications": [{"entity": "publication", "iuid": "9864771f755242af9eb21b672442feb0", "links": {"self": {"href": "https://publications.scilifelab.se/publication/9864771f755242af9eb21b672442feb0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/9864771f755242af9eb21b672442feb0"}}, "title": "Development and analytical validation of a targeted short-read next generation sequencing-based pharmacogenetic panel for comprehensive variant detection.", "authors": [{"family": "Gr\u00e9en", "given": "Anna", "initials": "A"}, {"family": "Fredriksson", "given": "Nils Johan", "initials": "NJ"}, {"family": "Andresen", "given": "Michael", "initials": "M"}, {"family": "Jonasson", "given": "Jon", "initials": "J"}, {"family": "Appell", "given": "Malin Lindqvist", "initials": "ML"}, {"family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}], "type": "journal article", "published": "2026-08-00", "journal": {"title": "British Journal of Pharmacology", "issn": "1476-5381", "volume": "183", "issue": "16", "pages": "4735-4760", "issn-l": "0007-1188"}, "abstract": "Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high-quality pharmacogenetic test panel for clinical use with a less expensive technique than high-coverage whole-genome sequencing.\n\nWe designed a targeted pan-pharmacogenomics (pan-PGx) panel based on Twist probe capture by applying Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines and aggregated data from PharmVar, PharmGKB and IPD-IMGT/HLA. Sequencing was performed using Illumina short-read sequencing. In-house computer scripts combined with freely available software, particularly PharmCAT, were used for the analysis. Validation was largely performed with Genetic Testing Reference Materials Coordination Program (GeT-RM) DNA from Coriell when applicable, otherwise with DNA from clinically well-documented material.\n\nThe validation showed that the method is both accurate and well-suited for large-scale clinical testing of pharmacogenes. Calls of single-nucleotide variants, InDels, and structural/hybrid genes and copy number variants in all major pharmacogenes could be translated into dose recommendations, making the test appropriate for clinical use.\n\nThis assay is suitable for clinical use and pharmacogenomic-guided drug treatments.", "doi": "10.1111/bph.70480", "pmid": "42086500", "labels": {"NGI Long read": "Service", "NGI Uppsala (Uppsala Genome Center)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [], "notes": [], "created": "2026-08-12T15:01:34.712Z", "modified": "2026-08-12T15:01:34.745Z"}, {"entity": "publication", "iuid": "bc1322ec034a40f2b805278a57b8c967", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bc1322ec034a40f2b805278a57b8c967.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bc1322ec034a40f2b805278a57b8c967"}}, "title": "Genomic Medicine Sweden: Advancing precision medicine at the national level.", "authors": [{"family": "Edsj\u00f6", "given": "Anders", "initials": "A", "orcid": "0000-0001-8783-8284", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fae25d88855440194b9bb11b3d18bf8.json"}}, {"family": "Lindstrand", "given": "Anna", "initials": "A", "orcid": "0000-0003-0806-5602", "researcher": {"href": "https://publications.scilifelab.se/researcher/07f3e6152da043d38c7a81974fcf8c23.json"}}, {"family": "Baliakas", "given": "Panagiotis", "initials": "P", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications.scilifelab.se/researcher/17370bd509dc4b1081af5aed9e5117c7.json"}}, {"family": "Gisselsson", "given": "David", "initials": "D", "orcid": "0000-0002-0301-426X", "researcher": {"href": "https://publications.scilifelab.se/researcher/3653582762b14f9a9ad2fe6aba511115.json"}}, {"family": "M\u00f6lling", "given": "Paula", "initials": "P", "orcid": "0009-0000-1143-9105", "researcher": {"href": 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"Christian G", "initials": "CG"}, {"family": "Green", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}, {"family": "Nordgren", "given": "Ann", "initials": "A", "orcid": "0000-0003-3285-4281", "researcher": {"href": "https://publications.scilifelab.se/researcher/08e74c6ddc27493696beca0883027cdd.json"}}, {"family": "Taylan", "given": "Fulya", "initials": "F", "orcid": "0000-0002-2907-0235", "researcher": {"href": "https://publications.scilifelab.se/researcher/c250909cc40f42ff9d6e2f640d12451b.json"}}, {"family": "Hallbeck", "given": "Martin", "initials": "M", "orcid": "0000-0001-6716-0314", "researcher": {"href": "https://publications.scilifelab.se/researcher/17f7b361871045a1b1e3cdfec9ebe5ec.json"}}, {"family": "Hallb\u00e4ck", "given": "Erika T\u00e5ng", "initials": "ET", "orcid": "0000-0002-0787-8786", "researcher": {"href": 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{"href": "https://publications.scilifelab.se/researcher/15f660ec95994b6a83d540e48c9b7610.json"}}, {"family": "Karn\u00e5", "given": "Malin", "initials": "M", "orcid": "0009-0005-7554-5624", "researcher": {"href": "https://publications.scilifelab.se/researcher/47a8cf1747f44f27ad4100a1482ec366.json"}}, {"family": "Nystr\u00f6m", "given": "Katarina", "initials": "K"}, {"family": "Strid", "given": "Tobias", "initials": "T", "orcid": "0000-0002-2166-5170", "researcher": {"href": "https://publications.scilifelab.se/researcher/8294f89150574803a12bc1944714d12b.json"}}, {"family": "Sikora", "given": "Per", "initials": "P"}, {"family": "Johansson", "given": "Maria", "initials": "M"}, {"family": "Fagerqvist", "given": "Therese", "initials": "T", "orcid": "0009-0001-6198-204X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ae6ecce0d7244628b85f1e9eb1e081e.json"}}, {"family": "M\u00f6ller", "given": "Mirja Carlsson", "initials": "MC"}, {"family": "Frisell", "given": "Oskar", "initials": "O", "orcid": "0009-0004-3890-1848", "researcher": {"href": "https://publications.scilifelab.se/researcher/514d933cded443d5912d69c3ff79fb4a.json"}}, {"family": "Ulfendahl", "given": "Mats", "initials": "M", "orcid": "0000-0002-5692-7169", "researcher": {"href": "https://publications.scilifelab.se/researcher/e6cbed50b36449abb53c2d23d841a9b4.json"}}, {"family": "Friedman", "given": "Mikaela", "initials": "M", "orcid": "0000-0002-5483-9771", "researcher": {"href": "https://publications.scilifelab.se/researcher/f1507c81499748d8bf0ee1eb647a37d4.json"}}, {"family": "Cavelier", "given": "Lucia", "initials": "L", "orcid": "0009-0003-8195-370X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f01226edb140436da0c9d166c1f5fe51.json"}}, {"family": "Wirta", "given": "Valtteri", "initials": "V", "orcid": "0000-0003-3811-5439", "researcher": {"href": "https://publications.scilifelab.se/researcher/cba024b2e3c347f6b981922d984ad2d6.json"}}, {"family": "Fioretos", "given": "Thoas", "initials": "T", "orcid": "0000-0002-3235-6154", "researcher": {"href": "https://publications.scilifelab.se/researcher/35a5c1b6023345c6b1317c590bf80680.json"}}, {"family": "Rosenquist", "given": "Richard", "initials": "R", "orcid": "0000-0002-0211-8788", "researcher": {"href": "https://publications.scilifelab.se/researcher/b570128e641140fb964ae3241414f510.json"}}], "type": "journal article", "published": "2026-07-06", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "issn-l": "0954-6820"}, "abstract": "High-throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease-causing genetic alterations and facilitating individualised treatment and care. In response to these advances, Genomic Medicine Sweden (GMS) was established in 2017 as a national collaborative effort to accelerate implementation of genomics-based precision medicine within Sweden's regionally organized, publicly funded healthcare system. GMS brings together the seven university healthcare regions and their associated medical faculties, in collaboration with healthcare regions across Sweden, Science for Life Laboratory, patient organizations, industry and governmental agencies. Activities are coordinated through national disease-specific expert groups, supported by cross-cutting functions in bioinformatics, health economics, ethics, education and patient engagement. At the operational level, seven Genomic Medicine Centres, embedded at university hospitals, develop and deliver harmonised genomic diagnostics nationwide. The National Genomics Platform provides secure infrastructure for large-scale data storage, analysis, and national and international data sharing. Following initial project-based funding, GMS now receives long-term governmental support. This review describes the national implementation of genomic-based precision diagnostics, discusses challenges and lessons learnt, and highlights key milestones across disease areas, including whole-genome sequencing in RD and paediatric cancer, comprehensive genomic profiling of haematological malignancies and solid tumours, pathogen genomics in microbiology, pharmacogenomic testing and emerging applications of polygenic risk scores in complex diseases. Collectively, these efforts have contributed to more than 500,000 genomic tests being performed within Swedish healthcare between 2017 and 2025. Finally, we outline future diagnostic needs and priority areas to ensure sustainable, scalable and equitable access to precision medicine.", "doi": "10.1111/joim.70129", "pmid": "42410492", "labels": {"Clinical Genomics": "Collaborative", "Clinical Genomics Uppsala": "Collaborative"}, "xrefs": [], "notes": [], "created": "2026-08-07T07:54:44.627Z", "modified": "2026-08-07T07:54:45.660Z"}, {"entity": "publication", "iuid": "733bd4b2fcc74cb4882960d91b8e004a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/733bd4b2fcc74cb4882960d91b8e004a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/733bd4b2fcc74cb4882960d91b8e004a"}}, "title": "Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG", "authors": [{"family": "Ottosson", "given": "Nina E", "initials": "NE", "orcid": "0000-0003-2159-6731", "researcher": {"href": "https://publications.scilifelab.se/researcher/5e54acedff4e45bbaa661096b33f8f7c.json"}}, {"family": "Frampton", "given": "Damon J A", "initials": "DJA", "orcid": "0000-0003-0941-3330", "researcher": {"href": "https://publications.scilifelab.se/researcher/73c54f27d14e468d8ea0dc65bb71b5b3.json"}}, {"family": "Pipatpolkai", "given": "Tanadet", "initials": "T", "orcid": "0000-0001-5396-4784", "researcher": {"href": "https://publications.scilifelab.se/researcher/b629d00aa88d4db4a51692bd594e4117.json"}}, {"family": "Norman", "given": "Caitlyn", "initials": "C", "orcid": "0000-0003-2322-0367", "researcher": {"href": "https://publications.scilifelab.se/researcher/76236231afbf4ef5b43cb790ec4213fc.json"}}, {"family": "Karlsson", "given": "Urban", "initials": "U", "orcid": "0000-0002-9228-1625", "researcher": {"href": "https://publications.scilifelab.se/researcher/eb7fa0354374416ca2f928c56f4ffe81.json"}}, {"family": "Jauregi-Miguel", "given": "Amaia", "initials": "A", "orcid": "0000-0003-0938-7734", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd678c2b74f74975a83ca102fa473752.json"}}, {"family": "Venter", "given": "Maryke", "initials": "M", "orcid": "0009-0004-8319-3158", "researcher": {"href": "https://publications.scilifelab.se/researcher/e10766ad47d0470ab925b12c54e64bbe.json"}}, {"family": "Sridhar", "given": "Akshay", "initials": "A", "orcid": "0000-0003-0633-7707", "researcher": {"href": "https://publications.scilifelab.se/researcher/56c0ac56b98c43ff8b2a777b2424bd81.json"}}, {"family": "Larsson", "given": "H Peter", "initials": "HP"}, {"family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}, {"family": "Liin", "given": "Sara I", "initials": "SI", "orcid": "0000-0001-8493-0114", "researcher": {"href": "https://publications.scilifelab.se/researcher/e82a591108f24dcabf50779d88fc8844.json"}}], "type": "posted-content", "published": "2025-12-06", "journal": {"issn-l": null}, "abstract": null, "doi": "10.64898/2025.12.03.692044", "pmid": null, "labels": {"Chemical Biology Consortium Sweden": "Collaborative"}, "xrefs": [], "notes": [], "created": "2026-02-23T09:15:04.762Z", "modified": "2026-02-23T09:15:06.199Z"}, {"entity": "publication", "iuid": "1edd0b0187124503928edd662f1beb87", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1edd0b0187124503928edd662f1beb87.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1edd0b0187124503928edd662f1beb87"}}, "title": "Prediction models of persistent taxane-induced peripheral neuropathy among breast cancer survivors using whole-exome sequencing.", "authors": [{"family": "Engvall", "given": "Kristina", "initials": "K", "orcid": "0000-0002-7291-7227", "researcher": {"href": "https://publications.scilifelab.se/researcher/9d42004025f8455e9ea979abff4bd7c3.json"}}, {"family": "Uvdal", "given": "Hanna", "initials": "H", "orcid": "0009-0009-3191-495X", "researcher": {"href": "https://publications.scilifelab.se/researcher/76a13b46df5040da93bf5f1e9c8f31bb.json"}}, {"family": "Bj\u00f6rn", "given": "Niclas", "initials": "N", "orcid": "0000-0001-6806-4527", "researcher": {"href": "https://publications.scilifelab.se/researcher/a39cecc1714f4331b08a47f1f1bbe7ac.json"}}, {"family": "\u00c5vall-Lundqvist", "given": "Elisabeth", "initials": "E", "orcid": "0000-0001-7274-1770", "researcher": {"href": "https://publications.scilifelab.se/researcher/088f2c4f20ca4b3cb20490abeec77700.json"}}, {"family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}], "type": "journal article", "published": "2024-05-16", "journal": {"title": "NPJ Precis Oncol", "issn": "2397-768X", "volume": "8", "issue": "1", "pages": "102", "issn-l": null}, "abstract": "Persistent taxane-induced peripheral neuropathy (TIPN) is highly prevalent among early-stage breast cancer survivors (ESBCS) and has detrimental effect on quality of life. We leveraged logistic regression models to develop and validate polygenic prediction models to estimate the risk of persistent PN symptoms in a training cohort and validation cohort taking clinical risk factors into account. Based on 337 whole-exome sequenced ESBCS two of five prediction models for individual PN symptoms obtained AUC results above 60% when validated. Using the model for numbness in feet (35 SNVs) in the test cohort, 73% survivors were correctly predicted. For tingling in feet (55 SNVs) 70% were correctly predicted. Both models included SNVs from the ADAMTS20, APT6V0A2, CCDC88C, CYP2C8, EPHA5, NR1H3, PSKH2/APTV0D2, and SCN10A genes. For cramps in feet, difficulty climbing stairs and difficulty opening a jar the validation was unsuccessful. Polygenic prediction models including clinical risk factors can estimate the risk of persistent taxane-induced numbness in feet and tingling in feet in ESBCS.", "doi": "10.1038/s41698-024-00594-x", "pmid": "38755266", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "NGI Short read": "Service", "National Genomics Infrastructure": "Service", "Clinical Genomics Gothenburg": "Service", "Bioinformatics Support, Infrastructure and Training": "Service", "Bioinformatics Support for Computational Resources": "Service", "Bioinformatics (NBIS)": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11099113"}, {"db": "pii", "key": "10.1038/s41698-024-00594-x"}], "notes": [], "created": "2024-10-21T11:10:16.668Z", "modified": "2025-02-28T14:16:00.044Z"}, {"entity": "publication", "iuid": "b65e656b7fd14984a6c8a44d2edb0795", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b65e656b7fd14984a6c8a44d2edb0795.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b65e656b7fd14984a6c8a44d2edb0795"}}, "title": "Enhancer mutations modulate the severity of chemotherapy-induced myelosuppression.", "authors": [{"family": "Zhigulev", "given": "Artemy", "initials": "A", "orcid": "0000-0001-9251-1059", "researcher": {"href": "https://publications.scilifelab.se/researcher/81a7e8bb937744b5a18ed42d4f2dea5e.json"}}, {"family": "Norberg", "given": "Zandra", "initials": "Z"}, {"family": "Cordier", "given": "Julie", "initials": "J"}, {"family": "Spalinskas", "given": "Rapolas", "initials": "R", "orcid": "0000-0002-1648-6426", "researcher": {"href": "https://publications.scilifelab.se/researcher/18ca0b7337b849a49861aedf2971067e.json"}}, {"family": "Bassereh", "given": "Hassan", "initials": "H", "orcid": "0000-0002-9202-3765", "researcher": {"href": "https://publications.scilifelab.se/researcher/83cc119164de497f95b65f8ad11cac79.json"}}, {"family": "Bj\u00f6rn", "given": "Niclas", "initials": "N"}, {"family": "Pradhananga", "given": "Sailendra", "initials": "S", "orcid": "0000-0002-0834-3169", "researcher": {"href": "https://publications.scilifelab.se/researcher/c1917cb059924a779ac38e3023778461.json"}}, {"family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}, {"family": "Sahl\u00e9n", "given": "Pelin", "initials": "P", "orcid": "0000-0001-6943-9618", "researcher": {"href": "https://publications.scilifelab.se/researcher/d032e807335049b2ac8a5e2398dd48e7.json"}}], "type": "journal article", "published": "2024-03-00", "journal": {"title": "Life Sci. Alliance", "issn": "2575-1077", "volume": "7", "issue": "3", "issn-l": "2575-1077"}, "abstract": "Non-small cell lung cancer is often diagnosed at advanced stages, and many patients are still treated with classical chemotherapy. The unselective nature of chemotherapy often results in severe myelosuppression. Previous studies showed that protein-coding mutations could not fully explain the predisposition to myelosuppression. Here, we investigate the possible role of enhancer mutations in myelosuppression susceptibility. We produced transcriptome and promoter-interaction maps (using HiCap) of three blood stem-like cell lines treated with carboplatin or gemcitabine. Taking advantage of publicly available enhancer datasets, we validated HiCap results in silico and in living cells using epigenetic CRISPR technology. We also developed a network approach for interactome analysis and detection of differentially interacting genes. Differential interaction analysis provided additional information on relevant genes and pathways for myelosuppression compared with differential gene expression analysis at the bulk level. Moreover, we showed that enhancers of differentially interacting genes are highly enriched for variants associated with differing levels of myelosuppression. Altogether, our work represents a prominent example of integrative transcriptome and gene regulatory datasets analysis for the functional annotation of noncoding mutations.", "doi": "10.26508/lsa.202302244", "pmid": "38228368", "labels": {"NGI Short read": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10796589"}, {"db": "pii", "key": "7/3/e202302244"}], "notes": [], "created": "2024-03-18T09:44:22.332Z", "modified": "2025-02-28T14:23:45.768Z"}, {"entity": "publication", "iuid": "f6085b6a093542799cfce5d77056cf6d", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f6085b6a093542799cfce5d77056cf6d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f6085b6a093542799cfce5d77056cf6d"}}, "title": "Early changes in gene expression profiles in AML patients during induction chemotherapy.", "authors": [{"family": "Jakobsen", "given": "Ingrid", "initials": "I", "orcid": "0000-0003-4450-0333", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf014a7141ae4ebe854146cee082c6b2.json"}}, {"family": "Sundkvist", "given": "Max", "initials": "M"}, {"family": "Bj\u00f6rn", "given": "Niclas", "initials": "N", "orcid": "0000-0001-6806-4527", "researcher": {"href": "https://publications.scilifelab.se/researcher/a39cecc1714f4331b08a47f1f1bbe7ac.json"}}, {"family": "Gr\u00e9en", "given": "Henrik", "initials": "H", "orcid": "0000-0002-8015-5728", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d92037931f64b70b8d4bf78dab628b4.json"}}, {"family": "Lotfi", "given": "Kourosh", "initials": "K", "orcid": "0000-0001-5797-7232", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c292ca46bf444fd8b79adc76555e722.json"}}], "type": "journal article", "published": "2022-11-14", "journal": {"title": "BMC Genomics", "issn": "1471-2164", "issn-l": "1471-2164", "volume": "23", "issue": "1", "pages": "752"}, "abstract": "Elucidation of the genetic mechanisms underlying treatment response to standard induction chemotherapy in AML patients is warranted, in order to aid in risk-adapted treatment decisions as novel treatments are emerging. In this pilot study, we explored the treatment-induced expression patterns in a small cohort of AML patients by analyzing differential gene expression (DGE) over the first 2 days of induction chemotherapy.\n\nBlood samples were collected from ten AML patients at baseline (before treatment initiation) and during the first 2 days of treatment (Day 1; approximately 24 h, and Day 2; approximately 48 h after treatment initiation, respectively) and RNA was extracted for subsequent RNA sequencing. DGE between time points were assessed by pairwise analysis using the R package edgeR version 3.18.1 in all patients as well as in relation to treatment response (complete remission, CR, vs non-complete remission, nCR). Ingenuity Pathway Analysis (Qiagen) software was used for pathway analysis and visualization.\n\nAfter initial data quality control, two patients were excluded from further analysis, resulting in a final cohort of eight patients with data from all three timepoints. DGE analysis demonstrated activation of pathways with genes directly or indirectly associated with NF-\u03baB signaling. Significant activation of the NF-\u03baB pathway was seen in 50% of the patients 2 days after treatment start, while iNOS pathway effects could be identified already after 1 day. nCR patients displayed activation of pathways associated with cell cycle progression, oncogenesis and anti-apoptotic behavior, including the STAT3 pathway and Salvage pathways of pyrimidine ribonucleotides. Notably, a significant induction of cytidine deaminase, an enzyme responsible for the deamination of Ara-C, could be observed between baseline and Day 2 in the nCR patients but not in patients achieving CR.\n\nIn conclusion, we show that time-course analysis of gene expression represents a feasible approach to identify relevant pathways affected by standard induction chemotherapy in AML patients. This poses as a potential method for elucidating new drug targets and biomarkers for categorizing disease aggressiveness and evaluating treatment response. However, more studies on larger cohorts are warranted to elucidate the transcriptional basis for drug response.", "doi": "10.1186/s12864-022-08960-4", "pmid": "36376859", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Production)": "Service", "NGI Short read": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9664790"}, {"db": "pii", "key": "10.1186/s12864-022-08960-4"}], "notes": [], "created": "2022-12-19T10:42:55.959Z", "modified": "2023-10-16T15:31:03.123Z"}]}