{"entity": "researcher", "timestamp": "2026-08-07T19:15:49.134Z", "family": "Nivard", "given": "Michel", "initials": "M", "orcid": "0000-0003-2015-1888", "affiliations": ["Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.", "EMGO+ Institute for Health and Care Research, VU University &VU University Medical Center, Amsterdam 1081 HV, The Netherlands."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0d65d2277e7344a3a13f0d2193c6813b.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0d65d2277e7344a3a13f0d2193c6813b"}}, "publications": [{"entity": "publication", "iuid": "5321d052b82a493991baf82d30627863", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5321d052b82a493991baf82d30627863.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5321d052b82a493991baf82d30627863"}}, "title": "Genetic association study of childhood aggression across raters, instruments, and age.", "authors": [{"family": "Ip", "given": "Hill F", "initials": "HF", "orcid": "0000-0003-1991-5019", "researcher": {"href": "https://publications.scilifelab.se/researcher/b04deeb54c174ad5aaed5247d9303dd2.json"}}, {"family": "van der Laan", "given": "Camiel M", "initials": "CM"}, {"family": "Krapohl", "given": "Eva M L", "initials": "EML"}, {"family": "Brikell", "given": "Isabell", "initials": "I"}, {"family": "S\u00e1nchez-Mora", "given": "Cristina", "initials": "C", "orcid": "0000-0003-4211-1107", "researcher": {"href": "https://publications.scilifelab.se/researcher/b191e52b7d984841a81f05d77f7e0d08.json"}}, {"family": "Nolte", "given": "Ilja M", "initials": "IM", "orcid": "0000-0001-5047-4077", "researcher": {"href": "https://publications.scilifelab.se/researcher/abd76becaa8a4df284103c3e20261f10.json"}}, {"family": "St Pourcain", "given": "Beate", "initials": "B", "orcid": "0000-0002-4680-3517", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5cfdc61a13f46589373c8c4b5a15a47.json"}}, {"family": "Bolhuis", "given": "Koen", "initials": "K"}, {"family": "Palviainen", "given": "Teemu", "initials": "T", "orcid": "0000-0002-7847-8384", "researcher": {"href": "https://publications.scilifelab.se/researcher/bcbc4c92052b4819b5d7d821c0c421b0.json"}}, {"family": "Zafarmand", "given": "Hadi", "initials": "H"}, {"family": "Colodro-Conde", "given": "Luc\u00eda", "initials": "L", "orcid": "0000-0002-9004-364X", "researcher": {"href": "https://publications.scilifelab.se/researcher/a3d04cc447a34470a5063ae581eb9030.json"}}, {"family": "Gordon", "given": "Scott", "initials": "S", "orcid": "0000-0001-7623-328X", "researcher": {"href": "https://publications.scilifelab.se/researcher/8815739662214e75b60f71f0b1ca58a6.json"}}, {"family": "Zayats", "given": "Tetyana", "initials": "T"}, {"family": "Aliev", "given": "Fazil", "initials": "F", "orcid": "0000-0001-8357-4699", "researcher": {"href": "https://publications.scilifelab.se/researcher/85556629452a4054bf7228b5f7049811.json"}}, {"family": "Jiang", "given": "Chang", "initials": "C"}, {"family": "Wang", "given": "Carol A", "initials": "CA"}, {"family": "Saunders", "given": "Gretchen", "initials": "G"}, {"family": "Karhunen", "given": "Ville", "initials": "V", "orcid": "0000-0001-6064-1588", "researcher": {"href": "https://publications.scilifelab.se/researcher/219a89cb373447218073a1f58fb77864.json"}}, {"family": "Hammerschlag", "given": "Anke R", "initials": "AR"}, {"family": "Adkins", "given": "Daniel E", "initials": "DE"}, {"family": "Border", "given": "Richard", "initials": "R", "orcid": "0000-0002-6293-2968", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a0382c1a2bb4c0ca9e9c2256b0ce00b.json"}}, {"family": "Peterson", "given": "Roseann E", "initials": "RE"}, {"family": "Prinz", "given": "Joseph A", "initials": "JA"}, {"family": "Thiering", "given": "Elisabeth", "initials": "E"}, {"family": "Sepp\u00e4l\u00e4", "given": "Ilkka", "initials": "I"}, {"family": "Vilor-Tejedor", "given": "Nat\u00e0lia", "initials": "N"}, {"family": "Ahluwalia", "given": "Tarunveer S", "initials": "TS", "orcid": "0000-0002-7464-3354", "researcher": {"href": "https://publications.scilifelab.se/researcher/2fde142189574b44a72155785763a327.json"}}, {"family": "Day", "given": "Felix R", "initials": "FR", "orcid": "0000-0003-3789-7651", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d9ffc4d251a4469bcb97dd24dcc4218.json"}}, {"family": "Hottenga", "given": "Jouke-Jan", "initials": "J"}, {"family": "Allegrini", "given": "Andrea G", "initials": "AG"}, {"family": "Rimfeld", "given": "Kaili", "initials": "K", "orcid": "0000-0001-5139-065X", "researcher": {"href": "https://publications.scilifelab.se/researcher/660709eb850544ba8c84fbc86cb53ac6.json"}}, {"family": "Chen", "given": "Qi", "initials": "Q"}, {"family": "Lu", "given": "Yi", "initials": "Y", "orcid": "0000-0001-9933-3654", "researcher": {"href": "https://publications.scilifelab.se/researcher/4a73eafe0b0e4221a77b96800883413d.json"}}, {"family": "Martin", "given": "Joanna", "initials": "J"}, {"family": "Soler Artigas", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0002-3213-1107", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e0e1e065b024da28acc1e1e0d14c773.json"}}, {"family": "Rovira", "given": "Paula", "initials": "P"}, {"family": "Bosch", "given": "Rosa", "initials": "R", "orcid": "0000-0002-7596-183X", "researcher": {"href": "https://publications.scilifelab.se/researcher/86bdf80d16c34257b4aa6742ff396c89.json"}}, {"family": "Espa\u00f1ol", "given": "Gemma", "initials": "G"}, {"family": "Ramos Quiroga", "given": "Josep Antoni", "initials": "JA", "orcid": "0000-0003-1622-0350", "researcher": {"href": "https://publications.scilifelab.se/researcher/d301b6f1b0ca48b3a5c8c4b8e07a3984.json"}}, {"family": "Neumann", "given": "Alexander", "initials": "A", "orcid": "0000-0001-6653-3203", "researcher": {"href": "https://publications.scilifelab.se/researcher/e51ca6c997164410957bb8cac445d3e4.json"}}, {"family": "Ensink", "given": "Judith", "initials": "J"}, {"family": "Grasby", "given": "Katrina", "initials": "K", "orcid": "0000-0001-8539-0228", "researcher": {"href": "https://publications.scilifelab.se/researcher/a8e9d35817bc460ea594b892e5d2030e.json"}}, {"family": "Morosoli", "given": "Jos\u00e9 J", "initials": "JJ"}, {"family": "Tong", "given": "Xiaoran", "initials": "X"}, {"family": "Marrington", "given": "Shelby", "initials": "S"}, {"family": "Middeldorp", "given": "Christel", "initials": "C", "orcid": "0000-0002-6218-0428", "researcher": {"href": "https://publications.scilifelab.se/researcher/db38533fb54249b99f1d67d95e19af74.json"}}, {"family": "Scott", "given": "James G", "initials": "JG"}, {"family": "Vinkhuyzen", "given": "Anna", "initials": "A"}, {"family": "Shabalin", "given": "Andrey A", "initials": "AA"}, {"family": "Corley", "given": "Robin", "initials": "R"}, {"family": "Evans", "given": "Luke M", "initials": "LM", "orcid": "0000-0002-7458-1720", "researcher": {"href": "https://publications.scilifelab.se/researcher/ac3c651e69a9455d9e8cb7921afb05d9.json"}}, {"family": "Sugden", "given": "Karen", "initials": "K"}, {"family": "Alemany", "given": "Silvia", "initials": "S", "orcid": "0000-0002-7925-6767", "researcher": {"href": "https://publications.scilifelab.se/researcher/da641b351c9f48fcbd54a186d28806e5.json"}}, {"family": "Sass", "given": "L\u00e6rke", "initials": "L", "orcid": "0000-0002-5217-7014", "researcher": {"href": "https://publications.scilifelab.se/researcher/950b17ef41394606b8023743f86aba1c.json"}}, {"family": "Vinding", "given": "Rebecca", "initials": "R"}, {"family": "Ruth", "given": "Kate", "initials": "K", "orcid": "0000-0003-4966-9170", "researcher": {"href": "https://publications.scilifelab.se/researcher/e5569a5bc7384a75a5a98c2bf04ded7b.json"}}, {"family": "Tyrrell", "given": "Jess", "initials": "J"}, {"family": "Davies", "given": "Gareth E", "initials": "GE"}, {"family": "Ehli", "given": "Erik A", "initials": "EA", "orcid": "0000-0002-7865-3015", "researcher": {"href": "https://publications.scilifelab.se/researcher/16c7ee4d9b20410ba4975ffa49c4b03e.json"}}, {"family": "Hagenbeek", "given": "Fiona A", "initials": "FA", "orcid": "0000-0002-8773-0430", "researcher": {"href": "https://publications.scilifelab.se/researcher/1874bbcb93ed4633879199558ae54877.json"}}, {"family": "De Zeeuw", "given": "Eveline", "initials": "E"}, {"family": "Van Beijsterveldt", "given": "Toos C E M", "initials": "TCEM"}, {"family": "Larsson", "given": "Henrik", "initials": "H"}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications.scilifelab.se/researcher/e9276827839a4f3cb50dcaa2ad4708a5.json"}}, {"family": "Verhulst", "given": "Frank C", "initials": "FC"}, {"family": "Amin", "given": "Najaf", "initials": "N"}, {"family": "Whipp", "given": "Alyce M", "initials": "AM"}, {"family": "Korhonen", "given": "Tellervo", "initials": "T"}, {"family": "Vuoksimaa", "given": "Eero", "initials": "E"}, {"family": "Rose", "given": "Richard J", "initials": "RJ"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG", "orcid": "0000-0002-7276-3387", "researcher": {"href": "https://publications.scilifelab.se/researcher/273577b238854023a9dffe34dabc3551.json"}}, {"family": "Heath", "given": "Andrew C", "initials": "AC"}, {"family": "Madden", "given": "Pamela", "initials": "P"}, {"family": "Haavik", "given": "Jan", "initials": "J", "orcid": "0000-0001-7865-2808", "researcher": {"href": "https://publications.scilifelab.se/researcher/68db11f9f0c246bdb7cd7943fbdb2af0.json"}}, {"family": "Harris", "given": "Jennifer R", "initials": "JR"}, {"family": "Helgeland", "given": "\u00d8yvind", "initials": "\u00d8"}, {"family": "Johansson", "given": "Stefan", "initials": "S", "orcid": "0000-0002-2298-7008", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b957ea589b342fb9def8ce13ef3bd7e.json"}}, {"family": "Knudsen", "given": "Gun Peggy S", "initials": "GPS", "orcid": "0000-0002-6193-4291", "researcher": {"href": "https://publications.scilifelab.se/researcher/1d14dc1ad847447789b7d9b2176cd972.json"}}, {"family": "Njolstad", "given": "Pal Rasmus", "initials": "PR", "orcid": "0000-0003-0304-6728", "researcher": {"href": "https://publications.scilifelab.se/researcher/7369f0ad21d9406cadc53eec4b05a71b.json"}}, {"family": "Lu", "given": "Qing", "initials": "Q"}, {"family": "Rodriguez", "given": "Alina", "initials": "A", "orcid": "0000-0003-1209-8802", "researcher": {"href": "https://publications.scilifelab.se/researcher/3b887eeb21fe4ebd8e9ab58c409b052a.json"}}, {"family": "Henders", "given": "Anjali K", "initials": "AK"}, {"family": "Mamun", "given": "Abdullah", "initials": "A"}, {"family": "Najman", "given": "Jackob M", "initials": "JM"}, {"family": "Brown", "given": "Sandy", "initials": "S", "orcid": "0000-0001-8780-0323", "researcher": {"href": "https://publications.scilifelab.se/researcher/b7595d4595284a879786dedad90c490b.json"}}, {"family": "Hopfer", "given": "Christian", "initials": "C"}, {"family": "Krauter", "given": "Kenneth", "initials": "K"}, {"family": "Reynolds", "given": "Chandra", "initials": "C"}, {"family": "Smolen", "given": "Andrew", "initials": "A"}, {"family": "Stallings", "given": "Michael", "initials": "M"}, {"family": "Wadsworth", "given": "Sally", "initials": "S"}, {"family": "Wall", "given": "Tamara L", "initials": "TL"}, {"family": "Silberg", "given": "Judy L", "initials": "JL"}, {"family": "Miller", "given": "Allison", "initials": "A", "orcid": "0000-0003-3816-2251", "researcher": {"href": "https://publications.scilifelab.se/researcher/e6311431d086475abc6b2842984202be.json"}}, {"family": "Keltikangas-J\u00e4rvinen", "given": "Liisa", "initials": "L", "orcid": "0000-0002-7977-3852", "researcher": {"href": "https://publications.scilifelab.se/researcher/070ce33c4a654544beaccf943345ef6c.json"}}, {"family": "Hakulinen", "given": "Christian", "initials": "C"}, {"family": "Pulkki-R\u00e5back", "given": "Laura", "initials": "L"}, {"family": "Havdahl", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-9268-0423", "researcher": {"href": "https://publications.scilifelab.se/researcher/27ff8da085f7404c920bad58b6b907a3.json"}}, {"family": "Magnus", "given": "Per", "initials": "P"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Perry", "given": "John R B", "initials": "JRB", "orcid": "0000-0001-6483-3771", "researcher": {"href": "https://publications.scilifelab.se/researcher/39d95b143f6849b1b914bca9563218c8.json"}}, {"family": "Llop", "given": "Sabrina", "initials": "S"}, {"family": "Lopez-Espinosa", "given": "Maria-Jose", "initials": "M"}, {"family": "B\u00f8nnelykke", "given": "Klaus", "initials": "K"}, {"family": "Bisgaard", "given": "Hans", "initials": "H"}, {"family": "Sunyer", "given": "Jordi", "initials": "J"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T", "orcid": "0000-0002-2555-4427", "researcher": {"href": "https://publications.scilifelab.se/researcher/03ed59707dae4c8fb9e63ac1f7c398e3.json"}}, {"family": "Arseneault", "given": "Louise", "initials": "L", "orcid": "0000-0002-2938-2191", "researcher": {"href": "https://publications.scilifelab.se/researcher/0664e4afe7de4354924a1b39b87cf570.json"}}, {"family": "Standl", "given": "Marie", "initials": "M"}, {"family": "Heinrich", "given": "Joachim", "initials": "J"}, {"family": "Boden", "given": "Joseph", "initials": "J", "orcid": "0000-0003-1502-1608", "researcher": {"href": "https://publications.scilifelab.se/researcher/3543b6fb1f8e415ebff77901d4f25cbe.json"}}, {"family": "Pearson", "given": "John", "initials": "J", "orcid": "0000-0001-5607-4517", "researcher": {"href": "https://publications.scilifelab.se/researcher/ab30b4696c52461a8b8632d9bf5d0e2d.json"}}, {"family": "Horwood", "given": "L John", "initials": "LJ"}, {"family": "Kennedy", "given": "Martin", "initials": "M", "orcid": "0000-0002-6445-8526", "researcher": {"href": "https://publications.scilifelab.se/researcher/b3ca738758034d28ad823bde5256ffd9.json"}}, {"family": "Poulton", "given": "Richie", "initials": "R", "orcid": "0000-0002-1052-4583", "researcher": {"href": "https://publications.scilifelab.se/researcher/8f61fd90a9804126b169485da8cf65a1.json"}}, {"family": "Eaves", "given": "Lindon J", "initials": "LJ"}, {"family": "Maes", "given": "Hermine H", "initials": "HH"}, {"family": "Hewitt", "given": "John", "initials": "J"}, {"family": "Copeland", "given": "William E", "initials": "WE", "orcid": "0000-0002-1348-7781", "researcher": {"href": "https://publications.scilifelab.se/researcher/751b7c2a826748168fa3eab48fd71bc6.json"}}, {"family": "Costello", "given": "Elizabeth J", "initials": "EJ"}, {"family": "Williams", "given": "Gail M", "initials": "GM"}, {"family": "Wray", "given": "Naomi", "initials": "N", "orcid": "0000-0001-7421-3357", "researcher": {"href": "https://publications.scilifelab.se/researcher/15a175036d9f44f9b4090d7d431f78d7.json"}}, {"family": "J\u00e4rvelin", "given": "Marjo-Riitta", "initials": "M"}, {"family": "McGue", "given": "Matt", "initials": "M", "orcid": "0000-0002-5580-1433", "researcher": {"href": "https://publications.scilifelab.se/researcher/8e55e07667274620b817abebddcbede5.json"}}, {"family": "Iacono", "given": "William", "initials": "W"}, {"family": "Caspi", "given": "Avshalom", "initials": "A"}, {"family": "Moffitt", "given": "Terrie E", "initials": "TE"}, {"family": "Whitehouse", "given": "Andrew", "initials": "A"}, {"family": "Pennell", "given": "Craig E", "initials": "CE", "orcid": "0000-0002-0937-6165", "researcher": {"href": "https://publications.scilifelab.se/researcher/9e35a98141ce4350b6775593f87e40a5.json"}}, {"family": "Klump", "given": "Kelly L", "initials": "KL"}, {"family": "Burt", "given": "S Alexandra", "initials": "SA"}, {"family": "Dick", "given": "Danielle M", "initials": "DM", "orcid": "0000-0002-1636-893X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b2567011fc84f32a0a1f17c277dbefe.json"}}, {"family": "Reichborn-Kjennerud", "given": "Ted", "initials": "T"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG", "orcid": "0000-0003-4069-8020", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b445e5935f74fd6a71b2e92a9dac176.json"}}, {"family": "Medland", "given": "Sarah E", "initials": "SE", "orcid": "0000-0003-1382-380X", "researcher": {"href": "https://publications.scilifelab.se/researcher/da1f0230a912425c9237830be85aa642.json"}}, {"family": "Vrijkotte", "given": "Tanja", "initials": "T"}, {"family": "Kaprio", "given": "Jaakko", "initials": "J", "orcid": "0000-0002-3716-2455", "researcher": {"href": "https://publications.scilifelab.se/researcher/814d362333844b72a70cba9ebcf61e6f.json"}}, {"family": "Tiemeier", "given": "Henning", "initials": "H", "orcid": "0000-0002-4395-1397", "researcher": {"href": "https://publications.scilifelab.se/researcher/73e05bd74af344ba8d963463f49bb242.json"}}, {"family": "Davey Smith", "given": "George", "initials": "G", "orcid": "0000-0002-1407-8314", "researcher": {"href": "https://publications.scilifelab.se/researcher/0790d5850377432087ad3900af0044e0.json"}}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ", "orcid": "0000-0003-3925-3913", "researcher": {"href": "https://publications.scilifelab.se/researcher/65ee5f9938f547bcbe51cbaf5fd7a9ba.json"}}, {"family": "Casas", "given": "Miquel", "initials": "M"}, {"family": "Ribas\u00e9s", "given": "Marta", "initials": "M", "orcid": "0000-0003-1039-1116", "researcher": {"href": "https://publications.scilifelab.se/researcher/643ddd67f10547c3a68ab3c5cd9ee627.json"}}, {"family": "Lichtenstein", "given": "Paul", "initials": "P", "orcid": "0000-0003-3037-5287", "researcher": {"href": "https://publications.scilifelab.se/researcher/4db67c51837b4cdfa18cacbc3fca1173.json"}}, {"family": "Lundstr\u00f6m", "given": "Sebastian", "initials": "S"}, {"family": "Plomin", "given": "Robert", "initials": "R", "orcid": "0000-0002-0756-3629", "researcher": {"href": "https://publications.scilifelab.se/researcher/26e3ca0c39ff4a5087146d5125e0190f.json"}}, {"family": "Bartels", "given": "Meike", "initials": "M", "orcid": "0000-0002-9667-7555", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a91c095e993411b99e81e21f40d8597.json"}}, {"family": "Nivard", "given": "Michel G", "initials": "MG", "orcid": "0000-0003-2015-1888", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d65d2277e7344a3a13f0d2193c6813b.json"}}, {"family": "Boomsma", "given": "Dorret I", "initials": "DI", "orcid": "0000-0002-7099-7972", "researcher": {"href": "https://publications.scilifelab.se/researcher/4b66ab2525fd4a468e7a4ad14c955cb4.json"}}], "type": "journal article", "published": "2021-07-30", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "issn-l": "2158-3188", "volume": "11", "issue": "1", "pages": "413"}, "abstract": "Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P = 1.6E-06), PCDH7 (P = 2.0E-06), and IPO13 (P = 2.5E-06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations (rg) among rater-specific assessment of AGG ranged from rg = 0.46 between self- and teacher-assessment to rg = 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range [Formula: see text]: 0.19-1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (rg = ~-0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range [Formula: see text]: 0.46-0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG.", "doi": "10.1038/s41398-021-01480-x", "pmid": "34330890", "labels": {"NGI Uppsala (SNP&SEQ Technology Platform)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s41398-021-01480-x"}, {"db": "pmc", "key": "PMC8324785"}], "notes": [], "created": "2021-08-19T13:42:02.005Z", "modified": "2021-12-07T13:20:40.961Z"}, {"entity": "publication", "iuid": "88adbd607a954e539fe5a35a01aba19a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/88adbd607a954e539fe5a35a01aba19a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/88adbd607a954e539fe5a35a01aba19a"}}, "title": "Genetic loci associated with heart rate variability and their effects on cardiac disease risk.", "authors": [{"family": "Nolte", "given": "Ilja M", "initials": "IM", "orcid": "0000-0001-5047-4077", "researcher": {"href": "https://publications.scilifelab.se/researcher/abd76becaa8a4df284103c3e20261f10.json"}}, {"family": "Munoz", "given": "M Loretto", "initials": "ML"}, {"family": "Tragante", "given": "Vinicius", "initials": "V"}, {"family": "Amare", "given": "Azmeraw T", "initials": "AT", "orcid": "0000-0002-7940-0335", "researcher": {"href": "https://publications.scilifelab.se/researcher/028fd1a615ef4dc1a71067d82f094c9c.json"}}, {"family": "Jansen", "given": "Rick", "initials": "R", "orcid": "0000-0002-3333-6737", "researcher": {"href": "https://publications.scilifelab.se/researcher/bcd392c9b9784ebe8c8730e05463377a.json"}}, {"family": "Vaez", "given": "Ahmad", "initials": "A", "orcid": "0000-0001-9048-3795", "researcher": {"href": "https://publications.scilifelab.se/researcher/34a09aa88bc74e1285ddd71655dbddc3.json"}}, {"family": "von der Heyde", "given": "Benedikt", "initials": "B"}, {"family": "Avery", "given": "Christy L", "initials": "CL"}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Dierckx", "given": "Bram", "initials": "B"}, {"family": "van Dongen", "given": "Jenny", "initials": "J"}, {"family": "Gogarten", "given": "Stephanie M", "initials": "SM"}, {"family": "Goyette", "given": "Philippe", "initials": "P"}, {"family": "Hernesniemi", "given": "Jussi", "initials": "J"}, {"family": "Huikari", "given": "Ville", "initials": "V"}, {"family": "Hwang", "given": "Shih-Jen", "initials": "SJ"}, {"family": "Jaju", "given": "Deepali", "initials": "D"}, {"family": "Kerr", "given": "Kathleen F", "initials": "KF"}, {"family": "Kluttig", "given": "Alexander", "initials": "A"}, {"family": "Krijthe", "given": "Bouwe P", "initials": "BP"}, {"family": "Kumar", "given": "Jitender", "initials": "J"}, {"family": "van der Laan", "given": "Sander W", "initials": "SW", "orcid": "0000-0001-6888-1404", "researcher": {"href": "https://publications.scilifelab.se/researcher/9bd54ab413974b9096ff3d924f8b8eb6.json"}}, {"family": "Lyytik\u00e4inen", "given": "Leo-Pekka", "initials": "LP"}, {"family": "Maihofer", "given": "Adam X", "initials": "AX"}, {"family": "Minassian", "given": "Arpi", "initials": "A"}, {"family": "van der Most", "given": "Peter J", "initials": "PJ", "orcid": "0000-0001-8450-3518", "researcher": {"href": "https://publications.scilifelab.se/researcher/17cd11842111490ba5460f3093a366f3.json"}}, {"family": "M\u00fcller-Nurasyid", "given": "Martina", "initials": "M"}, {"family": "Nivard", "given": "Michel", "initials": "M", "orcid": "0000-0003-2015-1888", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d65d2277e7344a3a13f0d2193c6813b.json"}}, {"family": "Salvi", "given": "Erika", "initials": "E", "orcid": "0000-0002-2724-2291", "researcher": {"href": "https://publications.scilifelab.se/researcher/c5119a5a894746dc92bb484e0d5cc4a3.json"}}, {"family": "Stewart", "given": "James D", "initials": "JD"}, {"family": "Thayer", "given": "Julian F", "initials": "JF"}, {"family": "Verweij", "given": "Niek", "initials": "N", "orcid": "0000-0002-4303-7685", "researcher": {"href": "https://publications.scilifelab.se/researcher/7306319d42a640a483b937de588a17a4.json"}}, {"family": "Wong", "given": "Andrew", "initials": "A", "orcid": "0000-0003-2079-4779", "researcher": {"href": "https://publications.scilifelab.se/researcher/d4e71c13d81a4ec5a496737a5657c97e.json"}}, {"family": "Zabaneh", "given": "Delilah", "initials": "D"}, {"family": "Zafarmand", "given": "Mohammad H", "initials": "MH"}, {"family": "Abdellaoui", "given": "Abdel", "initials": "A"}, {"family": "Albarwani", "given": "Sulayma", "initials": "S"}, {"family": "Albert", "given": "Christine", "initials": "C"}, {"family": "Alonso", "given": "Alvaro", "initials": "A"}, {"family": "Ashar", "given": "Foram", "initials": "F"}, {"family": "Auvinen", "given": "Juha", "initials": "J"}, {"family": "Axelsson", "given": "Tomas", "initials": "T"}, {"family": "Baker", "given": "Dewleen G", "initials": "DG"}, {"family": "de Bakker", "given": "Paul I W", "initials": "PIW"}, {"family": "Barcella", "given": "Matteo", "initials": "M"}, {"family": "Bayoumi", "given": "Riad", "initials": "R"}, {"family": "Bieringa", "given": "Rob J", "initials": "RJ"}, {"family": "Boomsma", "given": "Dorret", "initials": "D"}, {"family": "Boucher", "given": "Gabrielle", "initials": "G"}, {"family": "Britton", "given": "Annie R", "initials": "AR"}, {"family": "Christophersen", "given": "Ingrid", "initials": "I"}, {"family": "Dietrich", "given": "Andrea", "initials": "A"}, {"family": "Ehret", "given": "George B", "initials": "GB"}, {"family": "Ellinor", "given": "Patrick T", "initials": "PT", "orcid": "0000-0002-2067-0533", "researcher": {"href": "https://publications.scilifelab.se/researcher/dd513dc49e0945bc8298f72d1244648d.json"}}, {"family": "Eskola", "given": "Markku", "initials": "M"}, {"family": "Felix", "given": "Janine F", "initials": "JF"}, {"family": "Floras", "given": "John S", "initials": "JS"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "Friberg", "given": "Peter", "initials": "P"}, {"family": "Gademan", "given": "Maaike G J", "initials": "MGJ"}, {"family": "Geyer", "given": "Mark A", "initials": "MA"}, {"family": "Giedraitis", "given": "Vilmantas", "initials": "V"}, {"family": "Hartman", "given": "Catharina A", "initials": "CA"}, {"family": "Hemerich", "given": "Daiane", "initials": "D"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Hottenga", "given": "Jouke-Jan", "initials": "JJ"}, {"family": "Huikuri", "given": "Heikki", "initials": "H"}, {"family": "Hutri-K\u00e4h\u00f6nen", "given": "Nina", "initials": "N"}, {"family": "Jouven", "given": "Xavier", "initials": "X"}, {"family": "Junttila", "given": "Juhani", "initials": "J"}, {"family": "Juonala", "given": "Markus", "initials": "M"}, {"family": "Kiviniemi", "given": "Antti M", "initials": "AM", "orcid": "0000-0002-1160-493X", "researcher": {"href": "https://publications.scilifelab.se/researcher/583df0b19f724b0395d90fd9f8785e50.json"}}, {"family": "Kors", "given": "Jan A", "initials": "JA"}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Kuznetsova", "given": "Tatiana", "initials": "T"}, {"family": "Laurie", "given": "Cathy C", "initials": "CC"}, {"family": "Lefrandt", "given": "Joop D", "initials": "JD"}, {"family": "Li", "given": "Yong", "initials": "Y"}, {"family": "Li", "given": "Yun", "initials": "Y"}, {"family": "Liao", "given": "Duanping", "initials": "D"}, {"family": "Limacher", "given": "Marian C", "initials": "MC"}, {"family": "Lin", "given": "Henry J", "initials": "HJ"}, {"family": "Lindgren", "given": "Cecilia M", "initials": "CM"}, {"family": "Lubitz", "given": "Steven A", "initials": "SA"}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "McKnight", "given": "Barbara", "initials": "B"}, {"family": "Zu Schwabedissen", "given": "Henriette Meyer", "initials": "HM"}, {"family": "Milaneschi", "given": "Yuri", "initials": "Y"}, {"family": "Mononen", "given": "Nina", "initials": "N"}, {"family": "Morris", "given": "Andrew P", "initials": "AP"}, {"family": "Nalls", "given": "Mike A", "initials": "MA"}, {"family": "Navis", "given": "Gerjan", "initials": "G"}, {"family": "Neijts", "given": "Melanie", "initials": "M"}, {"family": "Nikus", "given": "Kjell", "initials": "K"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "O'Connor", "given": "Daniel T", "initials": "DT"}, {"family": "Ormel", "given": "Johan", "initials": "J"}, {"family": "Perz", "given": "Siegfried", "initials": "S"}, {"family": "Peters", "given": "Annette", "initials": "A"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Raitakari", "given": "Olli T", "initials": "OT"}, {"family": "Risbrough", "given": "Victoria B", "initials": "VB"}, {"family": "Sinner", "given": "Moritz F", "initials": "MF"}, {"family": "Siscovick", "given": "David", "initials": "D"}, {"family": "Smit", "given": "Johannes H", "initials": "JH"}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Soliman", "given": "Elsayed Z", "initials": "EZ", "orcid": "0000-0001-5632-8150", "researcher": {"href": "https://publications.scilifelab.se/researcher/96e79156ff664c509217e8834a728c79.json"}}, {"family": "Sotoodehnia", "given": "Nona", "initials": "N"}, {"family": "Staessen", "given": "Jan A", "initials": "JA"}, {"family": "Stein", "given": "Phyllis K", "initials": "PK"}, {"family": "Stilp", "given": "Adrienne M", "initials": "AM"}, {"family": "Stolarz-Skrzypek", "given": "Katarzyna", "initials": "K"}, {"family": "Strauch", "given": "Konstantin", "initials": "K"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Swenne", "given": "Cees A", "initials": "CA"}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC", "orcid": "0000-0002-9681-9146", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7012e35025543379380cb90efd71243.json"}}, {"family": "Tardif", "given": "Jean-Claude", "initials": "JC"}, {"family": "Taylor", "given": "Kent D", "initials": "KD"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc9c2667a55b47a6a08aea764fab0946.json"}}, {"family": "Thornton", "given": "Timothy A", "initials": "TA"}, {"family": "Tinker", "given": "Lesley E", "initials": "LE"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG"}, {"family": "van Setten", "given": "Jessica", "initials": "J", "orcid": "0000-0002-4934-7510", "researcher": {"href": "https://publications.scilifelab.se/researcher/4be6dce84e8a4f46bf15f4de178f70ba.json"}}, {"family": "Voss", "given": "Andreas", "initials": "A"}, {"family": "Waldenberger", "given": "Melanie", "initials": "M"}, {"family": "Wilhelmsen", "given": "Kirk C", "initials": "KC"}, {"family": "Willemsen", "given": "Gonneke", "initials": "G"}, {"family": "Wong", "given": "Quenna", "initials": "Q"}, {"family": "Zhang", "given": "Zhu-Ming", "initials": "ZM"}, {"family": "Zonderman", "given": "Alan B", "initials": "AB"}, {"family": "Cusi", "given": "Daniele", "initials": "D"}, {"family": "Evans", "given": "Michele K", "initials": "MK"}, {"family": "Greiser", "given": "Halina K", "initials": "HK"}, {"family": "van der Harst", "given": "Pim", "initials": "P"}, {"family": "Hassan", "given": "Mohammad", "initials": "M"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "J\u00e4rvelin", "given": "Marjo-Riitta", "initials": "MR"}, {"family": "K\u00e4\u00e4b", "given": "Stefan", "initials": "S"}, {"family": "K\u00e4h\u00f6nen", "given": "Mika", "initials": "M"}, {"family": "Kivimaki", "given": "Mika", "initials": "M", "orcid": "0000-0002-4699-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f81f2fb70b14197829de8cd819ceaa6.json"}}, {"family": "Kooperberg", "given": "Charles", "initials": "C"}, {"family": "Kuh", "given": "Diana", "initials": "D"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Nievergelt", "given": "Caroline M", "initials": "CM"}, {"family": "O'Donnell", "given": "Chris J", "initials": "CJ"}, {"family": "Oldehinkel", "given": "Albertine J", "initials": "AJ"}, {"family": "Penninx", "given": "Brenda", "initials": "B"}, {"family": "Reiner", "given": "Alexander P", "initials": "AP"}, {"family": "Riese", "given": "Harri\u00ebtte", "initials": "H"}, {"family": "van Roon", "given": "Arie M", "initials": "AM"}, {"family": "Rioux", "given": "John D", "initials": "JD"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Sofer", "given": "Tamar", "initials": "T"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "Tiemeier", "given": "Henning", "initials": "H", "orcid": "0000-0002-4395-1397", "researcher": {"href": "https://publications.scilifelab.se/researcher/73e05bd74af344ba8d963463f49bb242.json"}}, {"family": "Vrijkotte", "given": "Tanja G M", "initials": "TGM"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications.scilifelab.se/researcher/7037429ef1304bdaabd837d242b1e6f5.json"}}, {"family": "Brundel", "given": "Bianca J J M", "initials": "BJJM"}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Whitsel", "given": "Eric A", "initials": "EA"}, {"family": "den Hoed", "given": "Marcel", "initials": "M"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "de Geus", "given": "Eco J C", "initials": "EJC"}], "type": "journal article", "published": "2017-06-14", "journal": {"volume": "8", "issn": "2041-1723", "issue": null, "pages": "15805", "title": "Nat Commun", "issn-l": "2041-1723"}, "abstract": "Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74