{"entity": "researcher", "timestamp": "2026-08-08T16:57:43.486Z", "family": "Benrick", "given": "Anna", "initials": "A", "orcid": "0000-0003-4616-6789", "affiliations": ["Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 423, 40530, Gothenburg, Sweden. anna.benrick@gu.se.", "School of Health Sciences, University of Sk\u00f6vde, 54128, Sk\u00f6vde, Sweden. anna.benrick@gu.se."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0b2939d573c04f0abc063ac18e97bd40.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0b2939d573c04f0abc063ac18e97bd40"}}, "publications": [{"entity": "publication", "iuid": "08b6731fb6f641a6a182b86cc3382112", "links": {"self": {"href": "https://publications.scilifelab.se/publication/08b6731fb6f641a6a182b86cc3382112.json"}, "display": {"href": "https://publications.scilifelab.se/publication/08b6731fb6f641a6a182b86cc3382112"}}, "title": "Maternal Adiponectin Decreases Placenta Nutrient Transport in Mice.", "authors": [{"family": "Samad", "given": "Manisha", "initials": "M", "orcid": "0009-0004-4926-9104", "researcher": {"href": "https://publications.scilifelab.se/researcher/bebdb554cab54dfeae35d7884add29d2.json"}}, {"family": "Ulfenborg", "given": "Benjamin", "initials": "B"}, {"family": "Soleimani Sani", "given": "Sahar", "initials": "S"}, {"family": "Bauz\u00e1 Thorbr\u00fcgge", "given": "Marco", "initials": "M"}, {"family": "Mohan Shrestha", "given": "Man", "initials": "M"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Maliqueo", "given": "Manuel", "initials": "M"}, {"family": "Stener-Victorin", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-3424-1502", "researcher": {"href": "https://publications.scilifelab.se/researcher/b56343efabb34afa9baecef059417a3a.json"}}, {"family": "Wernstedt Asterholm", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0755-5784", "researcher": {"href": "https://publications.scilifelab.se/researcher/45e1e47469f942fe8392109ca802f78c.json"}}, {"family": "Benrick", "given": "Anna", "initials": "A", "orcid": "0000-0003-4616-6789", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b2939d573c04f0abc063ac18e97bd40.json"}}], "type": "journal article", "published": "2025-04-30", "journal": {"title": "FASEB J.", "issn": "1530-6860", "volume": "39", "issue": "8", "pages": "e70556", "issn-l": "0892-6638"}, "abstract": "Women with obesity who develop gestational diabetes have lower serum adiponectin throughout pregnancy, suggesting that low levels impair the ability to handle metabolic challenges during pregnancy. The placenta expresses adiponectin receptors, and adiponectin could therefore indirectly affect the developing fetus. Here, we aimed to investigate how elevated maternal and fetal adiponectin affect placental function, fetal growth, and metabolism during pregnancy in normal-weight and obese mice. Wild-type (wt) and adiponectin-overexpressing (APNtg) mice were fed normal chow or a high fat/high sucrose (HF/HS) diet 8 weeks before and during pregnancy to induce obesity. Mice were euthanized and dissected on gestational day 18.5. Lipid, glucose, and amino acid tracers were administered to the obese pregnant dams to study nutrient uptake. The effects of elevated adiponectin on fetal liver and placental function were further investigated using global proteomics. A 40%-50% increase in serum adiponectin reduced fetal growth in dams fed a HF/HS diet, but not a normal chow diet. The uptake of glucose, lipid, and amino acid tracer was lower, along with decreased expression of several amino acid transporters in the placenta of APNtg dams on HF/HS diet. This suggests that adiponectin decreases placental transfer of nutrients. Livers of fetuses from APNtg dams showed downregulated lipid and amino acid metabolic pathways possibly reflecting an energy deficit. In conclusion, elevated serum adiponectin in obese dams reduced the placental transfer of nutrients, resulting in fetal growth restriction and altered fetal liver function. Maternal adiponectin levels were the main driver of placenta function. While this could be beneficial for pregnancy-related complications like babies born large for their gestation age, our study indicates that adiponectin should be in an optimal concentration range, neither too low nor too high, to prevent these complications.", "doi": "10.1096/fj.202403251RR", "pmid": "40249643", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12007623"}], "notes": [], "created": "2025-10-23T13:07:33.398Z", "modified": "2025-10-23T13:07:33.650Z"}, {"entity": "publication", "iuid": "41a34fed91444246874cb1bcd950c93c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/41a34fed91444246874cb1bcd950c93c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/41a34fed91444246874cb1bcd950c93c"}}, "title": "Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS.", "authors": [{"family": "Stener-Victorin", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-3424-1502", "researcher": {"href": "https://publications.scilifelab.se/researcher/b56343efabb34afa9baecef059417a3a.json"}}, {"family": "Eriksson", "given": "Gustaw", "initials": "G", "orcid": "0000-0003-0120-9028", "researcher": {"href": "https://publications.scilifelab.se/researcher/b246deafb88b40c593f3e61dff49c844.json"}}, {"family": "Mohan Shrestha", "given": "Man", "initials": "M"}, {"family": "Rodriguez Paris", "given": "Valentina", "initials": "V"}, {"family": "Lu", "given": "Haojiang", "initials": "H"}, {"family": "Banks", "given": "Jasmine", "initials": "J"}, {"family": "Samad", "given": "Manisha", "initials": "M"}, {"family": "Perian", "given": "Charl\u00e8ne", "initials": "C"}, {"family": "Jude", "given": "Baptiste", "initials": "B"}, {"family": "Engman", "given": "Viktor", "initials": "V"}, {"family": "Boi", "given": "Roberto", "initials": "R"}, {"family": "Nilsson", "given": "Emma", "initials": "E", "orcid": "0000-0001-5020-6582", "researcher": {"href": "https://publications.scilifelab.se/researcher/0e7ee7d6af9f4527b6aa527acc81c476.json"}}, {"family": "Ling", "given": "Charlotte", "initials": "C"}, {"family": "Nystr\u00f6m", "given": "Jenny", "initials": "J"}, {"family": "Wernstedt Asterholm", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0755-5784", "researcher": {"href": "https://publications.scilifelab.se/researcher/45e1e47469f942fe8392109ca802f78c.json"}}, {"family": "Turner", "given": "Nigel", "initials": "N"}, {"family": "Lanner", "given": "Johanna", "initials": "J"}, {"family": "Benrick", "given": "Anna", "initials": "A", "orcid": "0000-0003-4616-6789", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b2939d573c04f0abc063ac18e97bd40.json"}}], "type": "journal article", "published": "2024-01-05", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "12", "issn-l": "2050-084X"}, "abstract": "Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in women with PCOS, but these differences do not necessarily lead to changes in protein levels and biological function.\n\nTo advance our understanding of the molecular alterations in PCOS, we performed global proteomic and phosphorylation site analysis using tandem mass spectrometry, and analyzed gene expression and methylation. Adipose tissue and skeletal muscle were collected at baseline from 10 women with and without PCOS, and in women with PCOS after 5 weeks of treatment with electrical stimulation.\n\nPerilipin-1, a protein that typically coats the surface of lipid droplets in adipocytes, was increased whereas proteins involved in muscle contraction and type I muscle fiber function were downregulated in PCOS muscle. Proteins in the thick and thin filaments had many altered phosphorylation sites, indicating differences in protein activity and function. A mouse model was used to corroborate that androgen exposure leads to a shift in muscle fiber type in controls but not in skeletal muscle-specific androgen receptor knockout mice. The upregulated proteins in muscle post treatment were enriched in pathways involved in extracellular matrix organization and wound healing, which may reflect a protective adaptation to repeated contractions and tissue damage due to needling. A similar, albeit less pronounced, upregulation in extracellular matrix organization pathways was also seen in adipose tissue.\n\nOur results suggest that hyperandrogenic women with PCOS have higher levels of extra-myocellular lipids and fewer oxidative insulin-sensitive type I muscle fibers. These could be key factors leading to insulin resistance in PCOS muscle while electric stimulation-induced tissue remodeling may be protective.\n\nSwedish Research Council (2020-02485, 2022-00550, 2020-01463), Novo Nordisk Foundation (NNF22OC0072904), and IngaBritt and Arne Lundberg Foundation. Clinical trial number NTC01457209.", "doi": "10.7554/eLife.87592", "pmid": "38180081", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10945439"}, {"db": "pii", "key": "87592"}, {"db": "Dryad", "key": "10.5061/dryad.wwpzgmsr7"}], "notes": [], "created": "2024-11-27T16:35:02.013Z", "modified": "2024-11-27T16:35:03.495Z"}, {"entity": "publication", "iuid": "1103e19dc8b74508a72dbc8bf2f53fc1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1103e19dc8b74508a72dbc8bf2f53fc1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1103e19dc8b74508a72dbc8bf2f53fc1"}}, "title": "Elevated circulating adiponectin levels do not prevent anxiety-like behavior in a PCOS-like mouse model.", "authors": [{"family": "Samad", "given": "Manisha", "initials": "M"}, {"family": "Ek", "given": "Joakim", "initials": "J"}, {"family": "B\u00f6rchers", "given": "Stina", "initials": "S"}, {"family": "Krieger", "given": "Jean-Philippe", "initials": "JP", "orcid": "0000-0003-1913-4466", "researcher": {"href": "https://publications.scilifelab.se/researcher/b1105ccfff044340856418ab78e3baa8.json"}}, {"family": "Stener-Victorin", "given": "Elisabet", "initials": "E", "orcid": "0000-0002-3424-1502", "researcher": {"href": "https://publications.scilifelab.se/researcher/b56343efabb34afa9baecef059417a3a.json"}}, {"family": "Skibicka", "given": "Karolina P", "initials": "KP"}, {"family": "Asterholm", "given": "Ingrid Wernstedt", "initials": "IW", "orcid": "0000-0002-0755-5784", "researcher": {"href": "https://publications.scilifelab.se/researcher/45e1e47469f942fe8392109ca802f78c.json"}}, {"family": "Benrick", "given": "Anna", "initials": "A", "orcid": "0000-0003-4616-6789", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b2939d573c04f0abc063ac18e97bd40.json"}}], "type": "journal article", "published": "2024-01-04", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "14", "issue": "1", "pages": "563", "issn-l": "2045-2322"}, "abstract": "Polycystic ovary syndrome (PCOS) is associated with symptoms of moderate to severe anxiety and depression. Hyperandrogenism is a key feature together with lower levels of the adipocyte hormone adiponectin. Androgen exposure leads to anxiety-like behavior in female offspring while adiponectin is reported to be anxiolytic. Here we test the hypothesis that elevated adiponectin levels protect against the development of androgen-induced anxiety-like behavior. Pregnant mice overexpressing adiponectin (APNtg) and wildtypes were injected with vehicle or dihydrotestosterone to induce prenatal androgenization (PNA) in the offspring. Metabolic profiling and behavioral tests were performed in 4-month-old female offspring. PNA offspring spent more time in the closed arms of the elevated plus maze, indicating anxiety-like behavior. Intriguingly, neither maternal nor offspring adiponectin overexpression prevented an anxiety-like behavior in PNA-exposed offspring. However, adiponectin overexpression in dams had metabolic imprinting effects, shown as lower fat mass and glucose levels in their offspring. While serum adiponectin levels were elevated in APNtg mice, cerebrospinal fluid levels were similar between genotypes. Adiponectin overexpression improved metabolic functions but did not elicit anxiolytic effects in PNA-exposed offspring. These observations might be attributed to increased circulating but unchanged cerebrospinal fluid adiponectin levels in APNtg mice. Thus, increased adiponectin levels in the brain are likely needed to stimulate anxiolytic effects.", "doi": "10.1038/s41598-023-50503-8", "pmid": "38177175", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10766608"}, {"db": "pii", "key": "10.1038/s41598-023-50503-8"}], "notes": [], "created": "2024-09-15T11:36:54.305Z", "modified": "2024-09-15T11:36:55.162Z"}]}