{"entity": "researcher", "timestamp": "2026-06-14T15:48:27.314Z", "family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "affiliations": ["Division of Immunology, Department of Clinical Microbiology, Ume\u00e5 University, Ume\u00e5, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0add593fb7a74193afa74ff553aaa322.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0add593fb7a74193afa74ff553aaa322"}}, "publications": [{"entity": "publication", "iuid": "e981886f12a74ccd99562804b814129a", "links": {"self": {"href": "https://publications.scilifelab.se/publication/e981886f12a74ccd99562804b814129a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/e981886f12a74ccd99562804b814129a"}}, "title": "Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination.", "authors": [{"family": "Kaku", "given": "Chengzi I", "initials": "CI", "orcid": "0000-0002-9854-8351", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa373156aa094c7b91e621eaf7d7add9.json"}}, {"family": "Champney", "given": "Elizabeth R", "initials": "ER"}, {"family": "Normark", "given": "Johan", "initials": "J", "orcid": "0000-0001-5831-4369", "researcher": {"href": "https://publications.scilifelab.se/researcher/2ff458cccc2a422ca28ba878e98afb9c.json"}}, {"family": "Garcia", "given": "Marina", "initials": "M", "orcid": "0000-0002-9130-3933", "researcher": {"href": "https://publications.scilifelab.se/researcher/20fa6d5f40764b32a70f792f29d97e60.json"}}, {"family": "Johnson", "given": "Carl E", "initials": "CE"}, {"family": "Ahlm", "given": "Clas", "initials": "C", "orcid": "0000-0003-2018-8592", "researcher": {"href": "https://publications.scilifelab.se/researcher/0add593fb7a74193afa74ff553aaa322.json"}}, {"family": "Christ", "given": "Wanda", "initials": "W", "orcid": "0000-0003-3886-5248", "researcher": {"href": "https://publications.scilifelab.se/researcher/38fe3a44fdb547b885cce5b6f490b2bc.json"}}, {"family": "Sakharkar", "given": "Mrunal", "initials": "M", "orcid": "0000-0002-2717-5201", "researcher": {"href": "https://publications.scilifelab.se/researcher/0a93fe70686e477f9e6951a650818d08.json"}}, {"family": "Ackerman", "given": "Margaret E", "initials": "ME", "orcid": "0000-0002-4253-3476", "researcher": {"href": "https://publications.scilifelab.se/researcher/2457511cf8d249c5bc962d3991354175.json"}}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J", "orcid": "0000-0001-9076-1441", "researcher": {"href": "https://publications.scilifelab.se/researcher/95c1b345ae434fb383b7fe6a1d053c80.json"}}, {"family": "Forsell", "given": "Mattias N E", "initials": "MNE", "orcid": "0000-0001-6904-742X", "researcher": {"href": "https://publications.scilifelab.se/researcher/5947732f625a43e8a08055fc214649b6.json"}}, {"family": "Walker", "given": "Laura M", "initials": "LM", "orcid": "0000-0001-7704-3197", "researcher": {"href": "https://publications.scilifelab.se/researcher/ec65711d236a41c3b2b3098f6ae34b84.json"}}], "type": "journal article", "published": "2022-03-04", "journal": {"title": "Science", "issn": "1095-9203", "volume": "375", "issue": "6584", "pages": "1041-1047", "issn-l": "0036-8075"}, "abstract": "Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-specific serological and memory B cell (MBC) responses in individuals who received either homologous (ChAdOx1:ChAdOx1) or heterologous (ChAdOx1:mRNA-1273) prime-boost vaccination. Heterologous messenger RNA (mRNA) booster immunization induced higher serum neutralizing antibody and MBC responses against SARS-CoV-2 variants of concern (VOCs) compared with that of homologous ChAdOx1 boosting. Specificity mapping of circulating B cells revealed that mRNA-1273 boost immunofocused ChAdOx1-primed responses onto epitopes expressed on prefusion-stabilized S. Monoclonal antibodies isolated from mRNA-1273-boosted participants displayed overall higher binding affinities and increased breadth of reactivity against VOCs relative to those isolated from ChAdOx1-boosted individuals. Overall, the results provide molecular insight into the enhanced quality of the B cell response induced after heterologous mRNA booster vaccination.", "doi": "10.1126/science.abn2688", "pmid": "35143256", "labels": {"Autoimmunity and Serology Profiling": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC8939765"}], "notes": [], "created": "2023-04-08T19:26:07.659Z", "modified": "2023-04-08T19:26:07.828Z"}]}