{"entity": "researcher", "timestamp": "2026-08-10T13:47:30.702Z", "family": "Vestin", "given": "Holme", "initials": "H", "orcid": "0009-0005-6622-8897", "affiliations": ["Uppsala University Department of Medical Sciences, Uppsala, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/09ab6d55e8ab4f8b92ae43b924f7453f.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/09ab6d55e8ab4f8b92ae43b924f7453f"}}, "publications": [{"entity": "publication", "iuid": "45682d38345b42169cbcba464ca3a942", "links": {"self": {"href": "https://publications.scilifelab.se/publication/45682d38345b42169cbcba464ca3a942.json"}, "display": {"href": "https://publications.scilifelab.se/publication/45682d38345b42169cbcba464ca3a942"}}, "title": "Patients with systemic lupus erythematosus (SLE) have an increased bisphenol A methylation score linked to SLE risk genes and selected clinical subphenotypes.", "authors": [{"family": "Vestin", "given": "Holme", "initials": "H", "orcid": "0009-0005-6622-8897", "researcher": {"href": "https://publications.scilifelab.se/researcher/09ab6d55e8ab4f8b92ae43b924f7453f.json"}}, {"family": "Oparina", "given": "Nina", "initials": "N"}, {"family": "Eloranta", "given": "Maija-Leena", "initials": "ML"}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe4dd47b8ca1436e8a26fdea33f5e7f6.json"}}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications.scilifelab.se/researcher/0ab5989c3c604a96bf42b1b6f90434a0.json"}}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "researcher": {"href": "https://publications.scilifelab.se/researcher/053ed3b657124a1bab3a78dc685556e6.json"}}, {"family": "Imgenberg-Kreuz", "given": "Juliana", "initials": "J", "orcid": "0000-0002-7230-8990", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d4c2f630d484ee780c2c12aaabdb939.json"}}, {"family": "Leonard", "given": "Dag", "initials": "D", "orcid": "0000-0002-6275-7282", "researcher": {"href": "https://publications.scilifelab.se/researcher/42ed25c2f495484db4757f4fef51abae.json"}}], "type": "journal article", "published": "2025-09-25", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "11", "issue": "3", "issn-l": "2056-5933"}, "abstract": "Bisphenol A (BPA), a xenoestrogen that can alter DNA methylation status, has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). This study aimed to investigate whether methylation changes at BPA-sensitive 5'-C-phosphate-G-3' (CpG) sites are associated with SLE and clinical subphenotypes.\n\nA discovery cohort (n=747) and a replication cohort (n=388) including Swedish patients with SLE and healthy controls were investigated using the Illumina HM450k bead chip. BPA-sensitive CpG sites were selected if differentially methylated in \u22652 of 7 BPA exposure studies and supported by cell line data. A BPAAll score including 19 CpGs and a BPASLE score based on three CpG sites co-localised in the genome with SLE risk loci were calculated for each individual, analysed for associations with clinical data and then compared with publicly available transcriptomic data from BPA-treated cells.\n\nPatients with SLE had significantly higher BPASLE score than controls in the discovery (OR 1.34, p=4.6\u00d710-13), replication (OR 1.28, p=1.1\u00d710-5) and meta-analysis (OR 1.32, p=3.3\u00d710-17). Higher BPAAll score was associated with SLE in the discovery cohort (OR 1.05, p=2.3\u00d710-3) but not in the replication cohort (OR 1.04, p=0.12) with a significant difference in the meta-analysis (OR 1.05, p=7.0\u00d710-4). Both scores were associated with prednisolone treatment (p<0.001), and the BPASLE score was associated with serositis and autoantibodies (p<0.05). Transcriptomic analysis of BPA-treated cells revealed enrichment in pathways such as interferon and mitogen-activated protein kinase signalling.\n\nOur findings reveal a novel association between BPA exposure and DNA methylation changes in SLE, with potential implications for the regulation of immune-related gene expression.", "doi": "10.1136/rmdopen-2025-006021", "pmid": "40998523", "labels": {"National Genomics Infrastructure": "Service", "NGI SNP genotyping": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12481292"}, {"db": "pii", "key": "rmdopen-2025-006021"}], "notes": [], "created": "2025-11-07T07:30:46.128Z", "modified": "2025-11-07T07:30:46.264Z"}]}