{"entity": "researcher", "timestamp": "2026-08-17T01:35:23.365Z", "family": "Rudnik", "given": "Michal", "initials": "M", "orcid": "0000-0002-8716-6729", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/06eb8cb93ca24cf09d3b918a805265ce.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/06eb8cb93ca24cf09d3b918a805265ce"}}, "publications": [{"entity": "publication", "iuid": "63c1591154c34b159b1b0df1c7b4f5c5", "links": {"self": {"href": "https://publications.scilifelab.se/publication/63c1591154c34b159b1b0df1c7b4f5c5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/63c1591154c34b159b1b0df1c7b4f5c5"}}, "title": "In vivo dendritic cell reprogramming for cancer immunotherapy.", "authors": [{"family": "Ascic", "given": "Ervin", "initials": "E", "orcid": "0000-0002-3839-0572", "researcher": {"href": "https://publications.scilifelab.se/researcher/e36eb12383264c38ba4c0c945a22abb2.json"}}, {"family": "\u00c5kerstr\u00f6m", "given": "Fritiof", "initials": "F", "orcid": "0009-0005-4071-3771", "researcher": {"href": "https://publications.scilifelab.se/researcher/a59b28a350e949d3860d027744cf119b.json"}}, {"family": "Sreekumar Nair", "given": "Malavika", "initials": "M", "orcid": "0000-0003-1378-7247", "researcher": {"href": "https://publications.scilifelab.se/researcher/253e82ec1a5d4907b6a73cb36c5caaed.json"}}, {"family": "Rosa", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-3179-4160", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d418004376f46909c9a363323ca3195.json"}}, {"family": "Kurochkin", "given": "Ilia", "initials": "I", "orcid": "0000-0003-3100-0903", "researcher": {"href": "https://publications.scilifelab.se/researcher/215e3195c7a943578f6fc51e367fb3af.json"}}, {"family": "Zimmermannova", "given": "Olga", "initials": "O", "orcid": "0000-0002-5706-8124", "researcher": {"href": "https://publications.scilifelab.se/researcher/19ffa427694b45e4800bf54cc457bd3d.json"}}, {"family": "Catena", "given": "Xavier", "initials": "X", "orcid": "0000-0001-7885-2447", "researcher": {"href": "https://publications.scilifelab.se/researcher/26b6a173bb584f12ace6cd153d96df01.json"}}, {"family": "Rotankova", "given": "Nadezhda", "initials": "N"}, {"family": "Veser", "given": "Charlotte", "initials": "C", "orcid": "0009-0001-5807-9407", "researcher": {"href": "https://publications.scilifelab.se/researcher/1689da93344c46f8b6913c25d413fb99.json"}}, {"family": "Rudnik", "given": "Michal", "initials": "M", "orcid": "0000-0002-8716-6729", "researcher": {"href": "https://publications.scilifelab.se/researcher/06eb8cb93ca24cf09d3b918a805265ce.json"}}, {"family": "Ballocci", "given": "Tommaso", "initials": "T", "orcid": "0009-0004-1312-5539", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e8ad4790a1a455685505786da284df9.json"}}, {"family": "Sch\u00e4rer", "given": "Tiffany", "initials": "T", "orcid": "0009-0007-8008-9939", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3bae26f46ed4377bfad8681ccc510c4.json"}}, {"family": "Huang", "given": "Xiaoli", "initials": "X", "orcid": "0009-0004-3853-0020", "researcher": {"href": "https://publications.scilifelab.se/researcher/acc03717478442198880fb44b4217790.json"}}, {"family": "de Rosa Torres", "given": "Maria", "initials": "M", "orcid": "0009-0009-0005-7860", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ad5a93f5c84443cbedafa1801eac586.json"}}, {"family": "Renaud", "given": "Emilie", "initials": "E", "orcid": "0000-0003-4747-1195", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8c6b5f3558e40d0a602b222e8acb89c.json"}}, {"family": "Velasco Santiago", "given": "Marta", "initials": "M", "orcid": "0000-0002-3322-3513", "researcher": {"href": "https://publications.scilifelab.se/researcher/07d7bbbf18cf49c5aeeb8dbd73490582.json"}}, {"family": "Met", "given": "\u00d6zcan", "initials": "\u00d6", "orcid": "0000-0002-3256-7592", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4389dca3bd24be187fec732f2d73367.json"}}, {"family": "Askmyr", "given": "David", "initials": "D", "orcid": "0000-0003-1312-8524", "researcher": {"href": "https://publications.scilifelab.se/researcher/0249a39d931d4f5198312aa3125a105d.json"}}, {"family": "Lindstedt", "given": "Malin", "initials": "M", "orcid": "0000-0001-9136-1087", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc58fdfd7f0a40e2bf2fa21c2d2bea36.json"}}, {"family": "Greiff", "given": "Lennart", "initials": "L", "orcid": "0000-0002-7004-1989", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a6c63fee50b446da172ddbb30f69fb2.json"}}, {"family": "Ligeon", "given": "Laure-Anne", "initials": "LA"}, {"family": "Agarkova", "given": "Irina", "initials": "I", "orcid": "0009-0005-9518-087X", "researcher": {"href": "https://publications.scilifelab.se/researcher/0fa917dc3d36481db03dcb37f037543d.json"}}, {"family": "Svane", "given": "Inge Marie", "initials": "IM", "orcid": "0000-0002-9451-6037", "researcher": {"href": "https://publications.scilifelab.se/researcher/c83b2b9332ba40fd90e1bce8eafa4c40.json"}}, {"family": "Pires", "given": "Cristiana F", "initials": "CF", "orcid": "0000-0003-2985-6323", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dde1908f0e8470dbfac54d3202e0515.json"}}, {"family": "Rosa", "given": "F\u00e1bio F", "initials": "FF", "orcid": "0000-0002-7714-5852", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d6242040a284b6c9a2ee37f773e9adb.json"}}, {"family": "Pereira", "given": "Carlos-Filipe", "initials": "CF", "orcid": "0000-0002-9724-1382", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b298bb485b744fdb87f51ad579d0a79.json"}}], "type": "journal article", "published": "2024-10-18", "journal": {"title": "Science", "issn": "1095-9203", "volume": "386", "issue": "6719", "pages": "eadn9083", "issn-l": "0036-8075"}, "abstract": "Immunotherapy can lead to long-term survival for some cancer patients, yet generalized success has been hampered by insufficient antigen presentation and exclusion of immunogenic cells from the tumor microenvironment. Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as type 1 conventional dendritic cells. Reprogrammed tumor cells remodeled their tumor microenvironment, recruited, and expanded polyclonal cytotoxic T cells; induced tumor regressions; and established long-term systemic immunity in multiple mouse melanoma models. In human tumor spheroids and xenografts, reprogramming to immunogenic dendritic-like cells progressed independently of immunosuppression, which usually limits immunotherapy. Our study paves the way for human clinical trials of in vivo immune cell reprogramming for cancer immunotherapy.", "doi": "10.1126/science.adn9083", "pmid": "39236156", "labels": {"Clinical Genomics Lund": "Service"}, "xrefs": [{"db": "mid", "key": "EMS198548"}, {"db": "pmc", "key": "PMC7616765"}], "notes": [], "created": "2024-11-14T09:37:51.094Z", "modified": "2025-11-17T07:39:29.285Z"}, {"entity": "publication", "iuid": "5bfa787e725744feaa92a89872beb702", "links": {"self": {"href": "https://publications.scilifelab.se/publication/5bfa787e725744feaa92a89872beb702.json"}, "display": {"href": "https://publications.scilifelab.se/publication/5bfa787e725744feaa92a89872beb702"}}, "title": "A cancer immunotherapy modality based on dendritic cell reprogrammingin vivo", "authors": [{"family": "Ascic", "given": "Ervin", "initials": "E", "orcid": "0000-0002-3839-0572", "researcher": {"href": "https://publications.scilifelab.se/researcher/e36eb12383264c38ba4c0c945a22abb2.json"}}, {"family": "\u00c5kerstr\u00f6m", "given": "Fritiof", "initials": "F", "orcid": "0009-0005-4071-3771", "researcher": {"href": "https://publications.scilifelab.se/researcher/a59b28a350e949d3860d027744cf119b.json"}}, {"family": "Sreekumar Nair", "given": "Malavika", "initials": "M", "orcid": "0000-0003-1378-7247", "researcher": {"href": "https://publications.scilifelab.se/researcher/253e82ec1a5d4907b6a73cb36c5caaed.json"}}, {"family": "Rosa", "given": "Andr\u00e9", "initials": "A", "orcid": "0000-0002-3179-4160", "researcher": {"href": "https://publications.scilifelab.se/researcher/2d418004376f46909c9a363323ca3195.json"}}, {"family": "Kurochkin", "given": "Ilia", "initials": "I", "orcid": "0000-0003-3100-0903", "researcher": {"href": "https://publications.scilifelab.se/researcher/215e3195c7a943578f6fc51e367fb3af.json"}}, {"family": "Zimmermannova", "given": "Olga", "initials": "O", "orcid": "0000-0002-5706-8124", "researcher": {"href": "https://publications.scilifelab.se/researcher/19ffa427694b45e4800bf54cc457bd3d.json"}}, {"family": "Catena", "given": "Xavier", "initials": "X", "orcid": "0000-0001-7885-2447", "researcher": {"href": "https://publications.scilifelab.se/researcher/26b6a173bb584f12ace6cd153d96df01.json"}}, {"family": "Rotankova", "given": "Nadezhda", "initials": "N"}, {"family": "Veser", "given": "Charlotte", "initials": "C", "orcid": "0009-0001-5807-9407", "researcher": {"href": "https://publications.scilifelab.se/researcher/1689da93344c46f8b6913c25d413fb99.json"}}, {"family": "Rudnik", "given": "Michal", "initials": "M", "orcid": "0000-0002-8716-6729", "researcher": {"href": "https://publications.scilifelab.se/researcher/06eb8cb93ca24cf09d3b918a805265ce.json"}}, {"family": "Ballocci", "given": "Tommaso", "initials": "T", "orcid": "0009-0004-1312-5539", "researcher": {"href": "https://publications.scilifelab.se/researcher/4e8ad4790a1a455685505786da284df9.json"}}, {"family": "Sch\u00e4rer", "given": "Tiffany", "initials": "T", "orcid": "0009-0007-8008-9939", "researcher": {"href": "https://publications.scilifelab.se/researcher/e3bae26f46ed4377bfad8681ccc510c4.json"}}, {"family": "Huang", "given": "Xiaoli", "initials": "X", "orcid": "0009-0004-3853-0020", "researcher": {"href": "https://publications.scilifelab.se/researcher/acc03717478442198880fb44b4217790.json"}}, {"family": "de Rosa Torres", "given": "Maria", "initials": "M", "orcid": "0009-0009-0005-7860", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ad5a93f5c84443cbedafa1801eac586.json"}}, {"family": "Renaud", "given": "Emilie", "initials": "E", "orcid": "0000-0003-4747-1195", "researcher": {"href": "https://publications.scilifelab.se/researcher/f8c6b5f3558e40d0a602b222e8acb89c.json"}}, {"family": "Velasco Santiago", "given": "Marta", "initials": "M", "orcid": "0000-0002-3322-3513", "researcher": {"href": "https://publications.scilifelab.se/researcher/07d7bbbf18cf49c5aeeb8dbd73490582.json"}}, {"family": "Met", "given": "\u00d6zcan", "initials": "\u00d6", "orcid": "0000-0002-3256-7592", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4389dca3bd24be187fec732f2d73367.json"}}, {"family": "Askmyr", "given": "David", "initials": "D", "orcid": "0000-0003-1312-8524", "researcher": {"href": "https://publications.scilifelab.se/researcher/0249a39d931d4f5198312aa3125a105d.json"}}, {"family": "Lindstedt", "given": "Malin", "initials": "M", "orcid": "0000-0001-9136-1087", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc58fdfd7f0a40e2bf2fa21c2d2bea36.json"}}, {"family": "Greiff", "given": "Lennart", "initials": "L", "orcid": "0000-0002-7004-1989", "researcher": {"href": "https://publications.scilifelab.se/researcher/1a6c63fee50b446da172ddbb30f69fb2.json"}}, {"family": "Ligeon", "given": "Laure Anne", "initials": "LA", "orcid": "0000-0002-4522-5807", "researcher": {"href": "https://publications.scilifelab.se/researcher/1e58523b8a8248e19f1cf541084526f9.json"}}, {"family": "Agarkova", "given": "Irina", "initials": "I", "orcid": "0000-0002-0930-8541", "researcher": {"href": "https://publications.scilifelab.se/researcher/6ec369543f454531b7b7ce556b6546e6.json"}}, {"family": "Svane", "given": "Inge Marie", "initials": "IM", "orcid": "0000-0002-9451-6037", "researcher": {"href": "https://publications.scilifelab.se/researcher/c83b2b9332ba40fd90e1bce8eafa4c40.json"}}, {"family": "Pires", "given": "Cristiana F", "initials": "CF", "orcid": "0000-0003-2985-6323", "researcher": {"href": "https://publications.scilifelab.se/researcher/9dde1908f0e8470dbfac54d3202e0515.json"}}, {"family": "Rosa", "given": "F\u00e1bio F", "initials": "FF", "orcid": "0000-0002-7714-5852", "researcher": {"href": "https://publications.scilifelab.se/researcher/0d6242040a284b6c9a2ee37f773e9adb.json"}}, {"family": "Pereira", "given": "Carlos Filipe", "initials": "CF", "orcid": "0000-0002-9724-1382", "researcher": {"href": "https://publications.scilifelab.se/researcher/2b298bb485b744fdb87f51ad579d0a79.json"}}], "type": "posted-content", "published": "2024-07-11", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2024.07.08.602356", "pmid": null, "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [], "notes": [], "created": "2024-11-14T09:37:27.611Z", "modified": "2025-12-18T19:27:15.324Z"}]}