{"entity": "researcher", "timestamp": "2026-07-22T17:35:42.394Z", "family": "Ruan", "given": "Xixin", "initials": "X", "orcid": "0000-0002-4937-9168", "affiliations": ["Department of Gastroenterology, Central South University Third Xiangya Hospital, Changsha, Hunan, China."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e"}}, "publications": [{"entity": "publication", "iuid": "26b2d2e481ee4340b58cb2399170e18c", "links": {"self": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c.json"}, "display": {"href": "https://publications.scilifelab.se/publication/26b2d2e481ee4340b58cb2399170e18c"}}, "title": "Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.", "authors": [{"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixin", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Yuying", "initials": "Y", "orcid": "0000-0002-3231-7542", "researcher": {"href": "https://publications.scilifelab.se/researcher/019bd04ea79a42eda01be14c54af5090.json"}}, {"family": "Abramowitz", "given": "Sarah A", "initials": "SA"}, {"family": "Wang", "given": "Lijuan", "initials": "L", "orcid": "0000-0002-9797-0753", "researcher": {"href": "https://publications.scilifelab.se/researcher/97af8fc0299a4c25aa4f31841007a8f8.json"}}, {"family": "Jiang", "given": "Fangyuan", "initials": "F"}, {"family": "Xiong", "given": "Ying", "initials": "Y", "orcid": "0000-0001-7644-014X", "researcher": {"href": "https://publications.scilifelab.se/researcher/72484ccb61b140ca946294b68042c330.json"}}, {"family": "Levin", "given": "Michael G", "initials": "MG", "orcid": "0000-0002-9937-9932", "researcher": {"href": "https://publications.scilifelab.se/researcher/d165b2fd025f41fab9959e82610492a3.json"}}, {"family": "Voight", "given": "Benjamin F", "initials": "BF", "orcid": "0000-0002-6205-9994", "researcher": {"href": "https://publications.scilifelab.se/researcher/d3d9e9de96ee4983ba97efc14eb3d79b.json"}}, {"family": "Gill", "given": "Dipender", "initials": "D", "orcid": "0000-0001-7312-7078", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca049660534b4f18ab8a16da46ffca52.json"}}, {"family": "Burgess", "given": "Stephen", "initials": "S", "orcid": "0000-0001-5365-8760", "researcher": {"href": "https://publications.scilifelab.se/researcher/6fd2dcaf4dbb4e4c91c2af460b8fa98f.json"}}, {"family": "\u00c5kesson", "given": "Agneta", "initials": "A", "orcid": "0000-0001-9594-4140", "researcher": {"href": "https://publications.scilifelab.se/researcher/f699e3a40b424acd9461ca03f288d6bc.json"}}, {"family": "Micha\u00eblsson", "given": "Karl", "initials": "K"}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications.scilifelab.se/researcher/b878210396ae46eba9f04f78be5ff564.json"}}, {"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}], "type": "journal article", "published": "2025-07-11", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "6426", "issn-l": "2041-1723"}, "abstract": "Atrial fibrillation (AF) is a common cardiac arrhythmia with strong genetic components, yet its underlying molecular mechanisms and potential therapeutic targets remain incompletely understood. We conducted a cross-population genome-wide meta-analysis of 168,007 AF cases and identified 525 loci that met genome-wide significance. Two loci of PITX2 and ZFHX3 genes were identified as shared across populations of different ancestries. Comprehensive gene prioritization approaches reinforced the role of muscle development and heart contraction while also uncovering additional pathways, including cellular response to transforming growth factor-beta. Population-specific genetic correlations uncovered common and unique circulatory comorbidities between Europeans and Africans. Mendelian randomization identified modifiable risk factors and circulating proteins, informing disease prevention and drug development. Integrating genomic data from this cross-population genome-wide meta-analysis with proteomic profiling significantly enhanced AF risk prediction. This study advances our understanding of the genetic etiology of AF while also enhancing risk prediction, prevention strategies, and therapeutic development.", "doi": "10.1038/s41467-025-61720-2", "pmid": "40645996", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12254421"}, {"db": "pii", "key": "10.1038/s41467-025-61720-2"}], "notes": [], "created": "2025-11-28T10:45:39.870Z", "modified": "2025-11-28T10:45:40.305Z"}, {"entity": "publication", "iuid": "95cbfa77bb344c08bf41cb612bea42f1", "links": {"self": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1.json"}, "display": {"href": "https://publications.scilifelab.se/publication/95cbfa77bb344c08bf41cb612bea42f1"}}, "title": "Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology.", "authors": [{"family": "Larsson", "given": "Susanna C", "initials": "SC", "orcid": "0000-0003-0118-0341", "researcher": {"href": "https://publications.scilifelab.se/researcher/afe4b220a6c547e6aac27a10c5024a23.json"}}, {"family": "Chen", "given": "Jie", "initials": "J", "orcid": "0000-0002-4029-4192", "researcher": {"href": "https://publications.scilifelab.se/researcher/7dbfd7fc4a2d4fe38a244f78cf48dce2.json"}}, {"family": "Ruan", "given": "Xixian", "initials": "X", "orcid": "0000-0002-4937-9168", "researcher": {"href": "https://publications.scilifelab.se/researcher/05d92ee22a384cb0bc5a7bcdccb83d0e.json"}}, {"family": "Li", "given": "Xue", "initials": "X", "orcid": "0000-0001-6880-2577", "researcher": {"href": "https://publications.scilifelab.se/researcher/360d5c60409d415f8c6957d9e3373cd0.json"}}, {"family": "Yuan", "given": "Shuai", "initials": "S", "orcid": "0000-0001-5055-5627", "researcher": {"href": "https://publications.scilifelab.se/researcher/5a51e0853b654cdcb2d42ebc5d73b52a.json"}}], "type": "journal article", "published": "2025-03-03", "journal": {"title": "JNCI Cancer Spectr", "issn": "2515-5091", "volume": "9", "issue": "2", "issn-l": null}, "abstract": "The causes of bladder cancer are not completely understood. Our objective was to identify blood proteins and modifiable causal risk factors for bladder cancer by combining genome-wide association study (GWAS) and Mendelian randomization (MR) analyses.\n\nWe first performed a GWAS meta-analysis of 6984 bladder cancer case patients and 708 432 control individuals from 3 European databases. Next, we conducted 2-sample MR and colocalization analyses using data from the present GWAS and published GWAS meta-analyses on plasma proteins and modifiable factors.\n\nGenome-wide association study meta-analysis uncovered 17 bladder cancer susceptibility loci, of which 3 loci were novel. Genes were enriched in pathways related to the metabolic and catabolic processes of xenobiotics and cellular detoxification. Proteome-wide MR analysis based on cis-acting genetic variants revealed that higher plasma levels of glutathione S-transferases were strongly associated with a reduced risk of bladder cancer. There is strong evidence of colocalization between GSTM1 and bladder cancer. Finally, multivariable MR analyses of suspected risk factors for bladder cancer revealed independent causal associations between smoking and adiposity, particularly abdominal obesity, and risk of bladder cancer.\n\nFindings from this large-scale GWAS and multivariable MR analyses highlight the key role of detoxification processes, particularly glutathione S-transferase 1, as well as smoking and abdominal obesity in bladder cancer etiology.", "doi": "10.1093/jncics/pkaf014", "pmid": "39898788", "labels": {"Bioinformatics Support for Computational Resources": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11950924"}, {"db": "pii", "key": "7997273"}], "notes": [], "created": "2025-11-28T10:49:53.296Z", "modified": "2025-11-28T10:49:53.391Z"}]}