{"entity": "researcher", "timestamp": "2026-07-14T04:36:20.136Z", "family": "Damenti", "given": "Martina", "initials": "M", "orcid": "0000-0002-4209-5381", "affiliations": ["Department of Applied Physics and SciLifeLab, KTH Royal Institute of Technology, Stockholm, 17165, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/048f072498914ea9bc5fcc7d8ae0347e.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/048f072498914ea9bc5fcc7d8ae0347e"}}, "publications": [{"entity": "publication", "iuid": "88fd0d987ac54f598427b2b468187b1e", "links": {"self": {"href": "https://publications.scilifelab.se/publication/88fd0d987ac54f598427b2b468187b1e.json"}, "display": {"href": "https://publications.scilifelab.se/publication/88fd0d987ac54f598427b2b468187b1e"}}, "title": "Quantitative optical nanoscopy of mitochondrial-derived vesicles in neurons classifies pre-peroxisomal and clearing organelles.", "authors": [{"family": "Coceano", "given": "Giovanna", "initials": "G", "orcid": "0000-0001-6579-0857", "researcher": {"href": "https://publications.scilifelab.se/researcher/e35c28e14e134fe3b4c9ab9efa129df0.json"}}, {"family": "Alvelid", "given": "Jonatan", "initials": "J", "orcid": "0000-0002-3554-9322", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf7f3ec8624f4cef96f96b3c28ffc6b8.json"}}, {"family": "Damenti", "given": "Martina", "initials": "M", "orcid": "0000-0002-4209-5381", "researcher": {"href": "https://publications.scilifelab.se/researcher/048f072498914ea9bc5fcc7d8ae0347e.json"}}, {"family": "Ferretti", "given": "Gabriella", "initials": "G", "orcid": "0000-0003-1848-5950", "researcher": {"href": "https://publications.scilifelab.se/researcher/dc2029e30d4d4d6f9771f1e58d6fc929.json"}}, {"family": "Mueller", "given": "Johannes", "initials": "J"}, {"family": "Rorbach", "given": "Joanna", "initials": "J", "orcid": "0000-0002-2891-2840", "researcher": {"href": "https://publications.scilifelab.se/researcher/a069374613a7403b818ce7ca400f3627.json"}}, {"family": "Testa", "given": "Ilaria", "initials": "I", "orcid": "0000-0003-4005-4997", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d8e8420dada49d6a4ef1da7a06e02f1.json"}}], "type": "journal article", "published": "2026-01-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "17", "issue": "1", "pages": "419", "issn-l": "2041-1723"}, "abstract": "Healthy mitochondria are crucial for maintaining neuronal homeostasis. Their activity depends on a dynamic lipid and protein exchange through fusion, fission, and vesicular trafficking. Studying vesicles in neurons is challenging with conventional microscopy due to their small size, heterogeneity, and dynamics. We use multicolour stimulated emission depletion nanoscopy to uncover the ultrastructure of mitochondrial-derived vesicles (MDVs) in live neurons, biosensors to define their functional state, and a pulse-chase strategy to identify their turnover in situ. We identified three populations of vesicular structures: one transporting degradation products originating from oxidative stress, one shuttling cargo and newly translated proteins for local organelle biogenesis and one consisting of small, functional mitochondria. Furthermore, we provide evidence supporting that de novo peroxisomes biogenesis occurs via the fusion of endoplasmic reticulum and MDVs at mitochondrial sites. Our data provide mechanistic insight into organelle biogenesis driven by significant diversity in MDV morphology, functional state, and molecular composition.", "doi": "10.1038/s41467-025-68160-y", "pmid": "41507166", "labels": {"Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12796351"}, {"db": "pii", "key": "10.1038/s41467-025-68160-y"}], "notes": [], "created": "2026-01-20T18:41:24.213Z", "modified": "2026-01-20T18:41:24.588Z"}, {"entity": "publication", "iuid": "aa04e79f070d443fa12034401a222116", "links": {"self": {"href": "https://publications.scilifelab.se/publication/aa04e79f070d443fa12034401a222116.json"}, "display": {"href": "https://publications.scilifelab.se/publication/aa04e79f070d443fa12034401a222116"}}, "title": "Structural diversity of Arc oligomers within the excitatory synapse", "authors": [{"family": "Damenti", "given": "Martina", "initials": "M", "orcid": "0000-0002-4209-5381", "researcher": {"href": "https://publications.scilifelab.se/researcher/048f072498914ea9bc5fcc7d8ae0347e.json"}}, {"family": "Coceano", "given": "Giovanna", "initials": "G", "orcid": "0000-0001-6579-0857", "researcher": {"href": "https://publications.scilifelab.se/researcher/e35c28e14e134fe3b4c9ab9efa129df0.json"}}, {"family": "Mendes Silva", "given": "Mariline", "initials": "M", "orcid": "0000-0003-0972-0816", "researcher": {"href": "https://publications.scilifelab.se/researcher/74066ca16b6b49c6a6dacc883cd9cb29.json"}}, {"family": "Alvelid", "given": "Jonatan", "initials": "J", "orcid": "0000-0002-3554-9322", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf7f3ec8624f4cef96f96b3c28ffc6b8.json"}}, {"family": "Sgattoni", "given": "Chiara", "initials": "C", "orcid": "0000-0003-0410-4635", "researcher": {"href": "https://publications.scilifelab.se/researcher/2329398b9773426581a07460ae5e6301.json"}}, {"family": "Rems", "given": "Lea", "initials": "L", "orcid": "0000-0001-7470-4367", "researcher": {"href": "https://publications.scilifelab.se/researcher/7d5bba0d82f446cd89d002306dd35243.json"}}, {"family": "Masullo", "given": "Luciano A", "initials": "LA", "orcid": "0000-0001-8664-5448", "researcher": {"href": "https://publications.scilifelab.se/researcher/f0f92a2d7a0d42ed99cbe12c61ef67e8.json"}}, {"family": "Unterauer", "given": "Eduard M", "initials": "EM"}, {"family": "Kowalewski", "given": "Rafal", "initials": "R"}, {"family": "Volpato", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3368-0017", "researcher": {"href": "https://publications.scilifelab.se/researcher/c3371085c3ff47bbaa74f525fb759c11.json"}}, {"family": "Delemotte", "given": "Lucie", "initials": "L", "orcid": "0000-0002-0828-3899", "researcher": {"href": "https://publications.scilifelab.se/researcher/2919e3b5cf0f466f980df8fd700bc306.json"}}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications.scilifelab.se/researcher/34d3b05d68d64f698ff08dc655d2fe26.json"}}, {"family": "Jungmann", "given": "Ralf", "initials": "R", "orcid": "0000-0003-4607-3312", "researcher": {"href": "https://publications.scilifelab.se/researcher/dcafc5088dbd4fdaa176f1c241212387.json"}}, {"family": "Testa", "given": "Ilaria", "initials": "I", "orcid": "0000-0003-4005-4997", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d8e8420dada49d6a4ef1da7a06e02f1.json"}}], "type": "posted-content", "published": "2024-06-06", "journal": {"title": "biorxiv", "issn": null, "issn-l": null, "volume": null, "issue": null, "pages": null}, "abstract": null, "doi": "10.1101/2024.06.05.597462", "pmid": null, "labels": {"Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [], "notes": [], "created": "2024-08-27T07:49:56.213Z", "modified": "2025-12-18T19:27:31.714Z"}, {"entity": "publication", "iuid": "b7eb97ccbb1e4b5ea42f76b086428147", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b7eb97ccbb1e4b5ea42f76b086428147.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b7eb97ccbb1e4b5ea42f76b086428147"}}, "title": "Blue-shift photoconversion of near-infrared fluorescent proteins for labeling and tracking in living cells and organisms.", "authors": [{"family": "Pennacchietti", "given": "Francesca", "initials": "F", "orcid": "0000-0003-1769-972X", "researcher": {"href": "https://publications.scilifelab.se/researcher/4ebc891d5d09473bba00fc49ca1c321b.json"}}, {"family": "Alvelid", "given": "Jonatan", "initials": "J", "orcid": "0000-0002-3554-9322", "researcher": {"href": "https://publications.scilifelab.se/researcher/bf7f3ec8624f4cef96f96b3c28ffc6b8.json"}}, {"family": "Morales", "given": "Rodrigo A", "initials": "RA", "orcid": "0000-0003-4382-5777", "researcher": {"href": "https://publications.scilifelab.se/researcher/61802da2579446d5b2a73c4f06b9969e.json"}}, {"family": "Damenti", "given": "Martina", "initials": "M", "orcid": "0000-0002-4209-5381", "researcher": {"href": "https://publications.scilifelab.se/researcher/048f072498914ea9bc5fcc7d8ae0347e.json"}}, {"family": "Ollech", "given": "Dirk", "initials": "D", "orcid": "0000-0002-9490-7070", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f2a4dbad2c542bab727d53bcd065748.json"}}, {"family": "Oliinyk", "given": "Olena S", "initials": "OS"}, {"family": "Shcherbakova", "given": "Daria M", "initials": "DM"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ", "orcid": "0000-0001-9522-9729", "researcher": {"href": "https://publications.scilifelab.se/researcher/6c6a2dde2d8f40ef82dfba0cf1b52c0d.json"}}, {"family": "Verkhusha", "given": "Vladislav V", "initials": "VV"}, {"family": "Testa", "given": "Ilaria", "initials": "I", "orcid": "0000-0003-4005-4997", "researcher": {"href": "https://publications.scilifelab.se/researcher/5d8e8420dada49d6a4ef1da7a06e02f1.json"}}], "type": "journal article", "published": "2023-12-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "8402", "issn-l": "2041-1723"}, "abstract": "Photolabeling of intracellular molecules is an invaluable approach to studying various dynamic processes in living cells with high spatiotemporal precision. Among fluorescent proteins, photoconvertible mechanisms and their products are in the visible spectrum (400-650 nm), limiting their in vivo and multiplexed applications. Here we report the phenomenon of near-infrared to far-red photoconversion in the miRFP family of near infrared fluorescent proteins engineered from bacterial phytochromes. This photoconversion is induced by near-infrared light through a non-linear process, further allowing optical sectioning. Photoconverted miRFP species emit fluorescence at 650 nm enabling photolabeling entirely performed in the near-infrared range. We use miRFPs as photoconvertible fluorescent probes to track organelles in live cells and in vivo, both with conventional and super-resolution microscopy. The spectral properties of miRFPs complement those of GFP-like photoconvertible proteins, allowing strategies for photoconversion and spectral multiplexed applications.", "doi": "10.1038/s41467-023-44054-9", "pmid": "38114484", "labels": {"Integrated Microscopy Technologies Stockholm": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10730883"}, {"db": "pii", "key": "10.1038/s41467-023-44054-9"}], "notes": [], "created": "2024-01-10T11:23:28.249Z", "modified": "2024-01-10T11:23:28.386Z"}]}