{"entity": "researcher", "timestamp": "2026-07-17T05:07:15.463Z", "family": "Vil\u00e9n", "given": "Liisa K", "initials": "LK", "orcid": "0000-0001-9184-4847", "affiliations": ["Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. liisa.vilen@astrazeneca.com.", "Division of Pharmaceutical Biosciences, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland. liisa.vilen@astrazeneca.com."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/03d10eddd2a84a22afa0beb276af4f59.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/03d10eddd2a84a22afa0beb276af4f59"}}, "publications": [{"entity": "publication", "iuid": "1495b67f923e43a5b3548539c1ca1303", "links": {"self": {"href": "https://publications.scilifelab.se/publication/1495b67f923e43a5b3548539c1ca1303.json"}, "display": {"href": "https://publications.scilifelab.se/publication/1495b67f923e43a5b3548539c1ca1303"}}, "title": "Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system.", "authors": [{"family": "Rigal", "given": "Sophie", "initials": "S"}, {"family": "Casas", "given": "Bel\u00e9n", "initials": "B"}, {"family": "Kanebratt", "given": "Kajsa P", "initials": "KP"}, {"family": "Wennberg Huldt", "given": "Charlotte", "initials": "C"}, {"family": "Magnusson", "given": "Lisa U", "initials": "LU"}, {"family": "M\u00fcllers", "given": "Erik", "initials": "E", "orcid": "0000-0002-2176-3248", "researcher": {"href": "https://publications.scilifelab.se/researcher/73a060ead5074f1aa3c0e782665814a8.json"}}, {"family": "Karlsson", "given": "Fredrik", "initials": "F"}, {"family": "Clausen", "given": "Maryam", "initials": "M"}, {"family": "Hansson", "given": "Sara F", "initials": "SF"}, {"family": "Leonard", "given": "Louise", "initials": "L"}, {"family": "Cairns", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9982-1401", "researcher": {"href": "https://publications.scilifelab.se/researcher/e7c0d942bccc46ef9afe4a3578aa4841.json"}}, {"family": "Jansson L\u00f6fmark", "given": "Rasmus", "initials": "R"}, {"family": "\u00c4mm\u00e4l\u00e4", "given": "Carina", "initials": "C"}, {"family": "Marx", "given": "Uwe", "initials": "U"}, {"family": "Gennemark", "given": "Peter", "initials": "P", "orcid": "0000-0002-7865-7454", "researcher": {"href": "https://publications.scilifelab.se/researcher/75d3c260cab344f49e8a79cbb2ea6a6f.json"}}, {"family": "Cedersund", "given": "Gunnar", "initials": "G"}, {"family": "Andersson", "given": "Tommy B", "initials": "TB"}, {"family": "Vil\u00e9n", "given": "Liisa K", "initials": "LK", "orcid": "0000-0001-9184-4847", "researcher": {"href": "https://publications.scilifelab.se/researcher/03d10eddd2a84a22afa0beb276af4f59.json"}}], "type": "journal article", "published": "2024-07-18", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "7", "issue": "1", "pages": "877", "issn-l": "2399-3642"}, "abstract": "Current research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liver, on a microfluidic chip to enable diabetes research in a human-based in vitro system. Aided by mechanistic mathematical modeling, we demonstrate that hyperglycemia and high cortisone concentration induce glucose dysregulation in the pancreas-liver microphysiological system (MPS), mimicking a diabetic phenotype seen in patients with glucocorticoid-induced diabetes. In this diseased condition, the pancreas-liver MPS displays beta-cell dysfunction, steatosis, elevated ketone-body secretion, increased glycogen storage, and upregulated gluconeogenic gene expression. Conversely, a physiological culture condition maintains glucose tolerance and beta-cell function. This method was reproducible in two laboratories and was effective in multiple pancreatic islet donors. The model also provides a platform to identify new therapeutic proteins, as demonstrated with a combined transcriptome and proteome analysis.", "doi": "10.1038/s42003-024-06514-w", "pmid": "39025915", "labels": {"Glycoproteomics and MS Proteomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11258270"}, {"db": "pii", "key": "10.1038/s42003-024-06514-w"}], "notes": [], "created": "2024-11-27T15:36:58.123Z", "modified": "2024-11-27T15:36:58.294Z"}]}