{"entity": "researcher", "timestamp": "2026-10-18T01:06:53.540Z", "family": "Rydholm", "given": "Gabriel", "initials": "G", "orcid": "0009-0006-1667-1214", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden."], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/00ce6eaaa853448f90a00befb1c0a9bc.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/00ce6eaaa853448f90a00befb1c0a9bc"}}, "publications": [{"entity": "publication", "iuid": "72411705b6ec4f428d009e41c5e7e8fc", "links": {"self": {"href": "https://publications.scilifelab.se/publication/72411705b6ec4f428d009e41c5e7e8fc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/72411705b6ec4f428d009e41c5e7e8fc"}}, "title": "The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS.", "authors": [{"family": "Zamboni", "given": "Margherita", "initials": "M", "orcid": "0000-0003-0664-4707", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f196173b40b4819a5fcd11bf76a4e6e.json"}}, {"family": "Mart\u00ednez-Mart\u00edn", "given": "Adri\u00e1n", "initials": "A", "orcid": "0009-0008-2335-6460", "researcher": {"href": "https://publications.scilifelab.se/researcher/5df092a45590443fb0e2133827b0de28.json"}}, {"family": "Rydholm", "given": "Gabriel", "initials": "G", "orcid": "0009-0006-1667-1214", "researcher": {"href": "https://publications.scilifelab.se/researcher/00ce6eaaa853448f90a00befb1c0a9bc.json"}}, {"family": "H\u00e4neke", "given": "Timm", "initials": "T", "orcid": "0000-0002-9734-8307", "researcher": {"href": "https://publications.scilifelab.se/researcher/90656853d1ac467fbc1033b2a3e446ac.json"}}, {"family": "Pintado Almeida", "given": "Laura", "initials": "L"}, {"family": "Se\u00e7ilmi\u015f", "given": "Deniz", "initials": "D"}, {"family": "Ziegenhain", "given": "Christoph", "initials": "C", "orcid": "0000-0003-2208-4877", "researcher": {"href": "https://publications.scilifelab.se/researcher/3297f21f1a174cd388ac586eda2b5177.json"}}, {"family": "Llorens-Bobadilla", "given": "Enric", "initials": "E", "orcid": "0000-0002-7891-1272", "researcher": {"href": "https://publications.scilifelab.se/researcher/3144601c466246cfa70acbe8c7ee00ee.json"}}], "type": "journal article", "published": "2026-02-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "29", "issue": "2", "pages": "337-349", "issn-l": "1097-6256"}, "abstract": "Enhancer elements direct cell-type-specific gene expression programs. After injury, cells change their transcriptional state to adapt to stress and initiate repair. Here we investigate how injury-induced transcriptional programs are encoded within enhancers in the mammalian CNS. Leveraging single-nucleus transcriptomics and chromatin accessibility profiling, we identify thousands of injury-induced, cell-type-specific enhancers in the mouse spinal cord after a contusion injury. These are abundant in glial cells and retain cell-type specificity, even when regulating shared wound response genes. By modeling glial injury-responsive enhancers using deep learning, we reveal that their architecture encodes cell-type specificity by integrating generic stimulus response elements with cell identity programs. Finally, through in vivo enhancer screening, we demonstrate that injury-responsive enhancers can selectively target reactive astrocytes across the CNS using therapeutically relevant gene delivery vectors. Our decoding of the principles of injury-responsive enhancers enables the design of sequences that can be programmed to target disease-associated cell states.", "doi": "10.1038/s41593-025-02131-w", "pmid": "41331142", "labels": {"NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service", "NGI Short read": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12880913"}, {"db": "pii", "key": "10.1038/s41593-025-02131-w"}], "notes": [], "created": "2026-10-14T12:47:56.276Z", "modified": "2026-10-14T12:47:56.781Z"}]}