{"entity": "researcher", "timestamp": "2026-08-18T01:42:50.906Z", "family": "Jansen", "given": "Iris E", "initials": "IE", "orcid": "0000-0003-1901-8131", "affiliations": [], "links": {"self": {"href": "https://publications.scilifelab.se/researcher/0023d0046d8844abac6b071beabf71b8.json"}, "display": {"href": "https://publications.scilifelab.se/researcher/0023d0046d8844abac6b071beabf71b8"}}, "publications": [{"entity": "publication", "iuid": "ad07a7341fca458f96005a035573c8ce", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ad07a7341fca458f96005a035573c8ce.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ad07a7341fca458f96005a035573c8ce"}}, "title": "Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.", "authors": [{"family": "Jansen", "given": "Iris E", "initials": "IE", "orcid": "0000-0003-1901-8131", "researcher": {"href": "https://publications.scilifelab.se/researcher/0023d0046d8844abac6b071beabf71b8.json"}}, {"family": "Savage", "given": "Jeanne E", "initials": "JE", "orcid": "0000-0002-2034-8341", "researcher": {"href": "https://publications.scilifelab.se/researcher/d8768341f7f44f449c2f70a493cc556d.json"}}, {"family": "Watanabe", "given": "Kyoko", "initials": "K"}, {"family": "Bryois", "given": "Julien", "initials": "J"}, {"family": "Williams", "given": "Dylan M", "initials": "DM"}, {"family": "Steinberg", "given": "Stacy", "initials": "S", "orcid": "0000-0001-7726-5152", "researcher": {"href": "https://publications.scilifelab.se/researcher/9051c5beba2742ffabdd386bf9939fd3.json"}}, {"family": "Sealock", "given": "Julia", "initials": "J"}, {"family": "Karlsson", "given": "Ida K", "initials": "IK"}, {"family": "H\u00e4gg", "given": "Sara", "initials": "S", "orcid": "0000-0002-2452-1500", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1d010dfe5d84a33b6a6c7ec815ca3dc.json"}}, {"family": "Athanasiu", "given": "Lavinia", "initials": "L"}, {"family": "Voyle", "given": "Nicola", "initials": "N"}, {"family": "Proitsi", "given": "Petroula", "initials": "P", "orcid": "0000-0002-2553-6974", "researcher": {"href": "https://publications.scilifelab.se/researcher/724f31ac8bc746e7801728be49ab9cc2.json"}}, {"family": "Witoelar", "given": "Aree", "initials": "A"}, {"family": "Stringer", "given": "Sven", "initials": "S", "orcid": "0000-0003-3115-8532", "researcher": {"href": "https://publications.scilifelab.se/researcher/f7e6ae56d0474688b3722f58d33f385d.json"}}, {"family": "Aarsland", "given": "Dag", "initials": "D", "orcid": "0000-0001-6314-216X", "researcher": {"href": "https://publications.scilifelab.se/researcher/121af6702db54d68b1ca94e8c22a8688.json"}}, {"family": "Almdahl", "given": "Ina S", "initials": "IS", "orcid": "0000-0001-6070-4921", "researcher": {"href": "https://publications.scilifelab.se/researcher/8c99e3bce167471ba669e820cc6e0839.json"}}, {"family": "Andersen", "given": "Fred", "initials": "F"}, {"family": "Bergh", "given": "Sverre", "initials": "S"}, {"family": "Bettella", "given": "Francesco", "initials": "F"}, {"family": "Bjornsson", "given": "Sigurbjorn", "initials": "S"}, {"family": "Br\u00e6khus", "given": "Anne", "initials": "A"}, {"family": "Br\u00e5then", "given": "Geir", "initials": "G", "orcid": "0000-0003-3224-7983", "researcher": {"href": "https://publications.scilifelab.se/researcher/52e7ea4ab30548829139064396d7c044.json"}}, {"family": "de Leeuw", "given": "Christiaan", "initials": "C", "orcid": "0000-0003-1076-9828", "researcher": {"href": "https://publications.scilifelab.se/researcher/54a93840c735496c81a9514bbc564849.json"}}, {"family": "Desikan", "given": "Rahul S", "initials": "RS"}, {"family": "Djurovic", "given": "Srdjan", "initials": "S", "orcid": "0000-0002-8140-8061", "researcher": {"href": "https://publications.scilifelab.se/researcher/906538321c8e4f38b6bb4a7b0bc18fa3.json"}}, {"family": "Dumitrescu", "given": "Logan", "initials": "L"}, {"family": "Fladby", "given": "Tormod", "initials": "T"}, {"family": "Hohman", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-3377-7014", "researcher": {"href": "https://publications.scilifelab.se/researcher/079a5de2cf894db3b46faa3f6ba1e04e.json"}}, {"family": "Jonsson", "given": "Palmi V", "initials": "PV"}, {"family": "Kiddle", "given": "Steven J", "initials": "SJ", "orcid": "0000-0003-4350-7437", "researcher": {"href": "https://publications.scilifelab.se/researcher/6f86c2bca0014cf9aef8c215d97ce39c.json"}}, {"family": "Rongve", "given": "Arvid", "initials": "A"}, {"family": "Saltvedt", "given": "Ingvild", "initials": "I"}, {"family": "Sando", "given": "Sigrid B", "initials": "SB"}, {"family": "Selb\u00e6k", "given": "Geir", "initials": "G"}, {"family": "Shoai", "given": "Maryam", "initials": "M"}, {"family": "Skene", "given": "Nathan G", "initials": "NG", "orcid": "0000-0002-6807-3180", "researcher": {"href": "https://publications.scilifelab.se/researcher/0b4340cc0fa948eda26ce5618ebc0693.json"}}, {"family": "Snaedal", "given": "Jon", "initials": "J"}, {"family": "Stordal", "given": "Eystein", "initials": "E", "orcid": "0000-0002-2443-7923", "researcher": {"href": "https://publications.scilifelab.se/researcher/6eacc414991448c38cee92ac328eb4d3.json"}}, {"family": "Ulstein", "given": "Ingun D", "initials": "ID"}, {"family": "Wang", "given": "Yunpeng", "initials": "Y"}, {"family": "White", "given": "Linda R", "initials": "LR"}, {"family": "Hardy", "given": "John", "initials": "J"}, {"family": "Hjerling-Leffler", "given": "Jens", "initials": "J", "orcid": "0000-0002-4539-1776", "researcher": {"href": "https://publications.scilifelab.se/researcher/51675f0ff9aa47d89d6b2eb84a14820a.json"}}, {"family": "Sullivan", "given": "Patrick F", "initials": "PF"}, {"family": "van der Flier", "given": "Wiesje M", "initials": "WM"}, {"family": "Dobson", "given": "Richard", "initials": "R", "orcid": "0000-0003-4224-9245", "researcher": {"href": "https://publications.scilifelab.se/researcher/098ba38a51a64ba89362ed2a2e51455f.json"}}, {"family": "Davis", "given": "Lea K", "initials": "LK", "orcid": "0000-0001-5143-2282", "researcher": {"href": "https://publications.scilifelab.se/researcher/60132a034c8d412dbbb7fedbc9743d81.json"}}, {"family": "Stefansson", "given": "Hreinn", "initials": "H"}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications.scilifelab.se/researcher/679465193fba4887a68e2aec34ccfd8e.json"}}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Ripke", "given": "Stephan", "initials": "S"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications.scilifelab.se/researcher/56f384e8e2fd4a7383c7b26e88a828b2.json"}}, {"family": "Posthuma", "given": "Danielle", "initials": "D", "orcid": "0000-0001-7582-2365", "researcher": {"href": "https://publications.scilifelab.se/researcher/406e98180d174e8ca087f50074c025c9.json"}}], "type": "journal article", "published": "2019-03-00", "journal": {"volume": "51", "issn": "1546-1718", "issue": "3", "pages": "404-413", "title": "Nat. Genet.", "issn-l": "1061-4036"}, "abstract": "Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (rg = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD.", "doi": "10.1038/s41588-018-0311-9", "pmid": "30617256", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "mid", "key": "NIHMS1031924"}, {"db": "pmc", "key": "PMC6836675"}, {"db": "pii", "key": "10.1038/s41588-018-0311-9"}], "notes": [], "created": "2019-03-13T09:21:28.969Z", "modified": "2023-06-20T15:57:06.709Z"}]}