{"entity": "publication", "iuid": "fcf19a79c0f84e60b324b5b3d59f8cb0", "timestamp": "2026-08-08T04:08:18.980Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/fcf19a79c0f84e60b324b5b3d59f8cb0.json"}, "display": {"href": "https://publications.scilifelab.se/publication/fcf19a79c0f84e60b324b5b3d59f8cb0"}}, "title": "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.", "authors": [{"family": "Stsiapanava", "given": "Alena", "initials": "A"}, {"family": "Xu", "given": "Chenrui", "initials": "C"}, {"family": "Nishio", "given": "Shunsuke", "initials": "S", "orcid": "0000-0003-3420-2578", "researcher": {"href": "https://publications.scilifelab.se/researcher/418271e729d04268845cd61f734b44c0.json"}}, {"family": "Han", "given": "Ling", "initials": "L", "orcid": "0000-0001-9310-4789", "researcher": {"href": "https://publications.scilifelab.se/researcher/1f38b9eaca93474280189bb93b118817.json"}}, {"family": "Yamakawa", "given": "Nao", "initials": "N"}, {"family": "Carroni", "given": "Marta", "initials": "M"}, {"family": "Tunyasuvunakool", "given": "Kathryn", "initials": "K"}, {"family": "Jumper", "given": "John", "initials": "J", "orcid": "0000-0001-6169-6580", "researcher": {"href": "https://publications.scilifelab.se/researcher/74b09bf1cdfc4b17b7082781f11aa25a.json"}}, {"family": "de Sanctis", "given": "Daniele", "initials": "D", "orcid": "0000-0003-0391-8290", "researcher": {"href": "https://publications.scilifelab.se/researcher/191f6c2f187a4cf396364ee4316d36e3.json"}}, {"family": "Wu", "given": "Bin", "initials": "B", "orcid": "0000-0002-0883-8006", "researcher": {"href": "https://publications.scilifelab.se/researcher/76dd84c8134245d48bf28f63511fa1ba.json"}}, {"family": "Jovine", "given": "Luca", "initials": "L", "orcid": "0000-0002-2679-6946", "researcher": {"href": "https://publications.scilifelab.se/researcher/8507a7657f6b434ebc572453aa172b1e.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Nat. Struct. Mol. Biol.", "issn": "1545-9985", "issn-l": "1545-9985", "volume": "29", "issue": "3", "pages": "190-193"}, "abstract": "Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.", "doi": "10.1038/s41594-022-00729-3", "pmid": "35273390", "labels": {"Cryo-EM": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC8930769"}, {"db": "pii", "key": "10.1038/s41594-022-00729-3"}], "notes": [], "created": "2022-03-21T10:46:40.880Z", "modified": "2022-12-02T10:15:52.364Z"}