{"entity": "publication", "iuid": "f93fd2e8247d4dc182bf9c14fadcfee5", "timestamp": "2026-08-14T21:06:04.978Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f93fd2e8247d4dc182bf9c14fadcfee5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f93fd2e8247d4dc182bf9c14fadcfee5"}}, "title": "A single-cell multi-omic atlas of the human pancreas reveals potential for cellular plasticity across development, health, and disease.", "authors": [{"family": "Mereu", "given": "Elisabetta", "initials": "E"}, {"family": "Balboa", "given": "Diego", "initials": "D"}, {"family": "Liebig", "given": "Johannes", "initials": "J"}, {"family": "Gonzalez-Herrero", "given": "Aitor", "initials": "A"}, {"family": "Casals", "given": "Anna Martinez", "initials": "AM"}, {"family": "Mardamshina", "given": "Mariya", "initials": "M"}, {"family": "Mollandin", "given": "Fanny", "initials": "F"}, {"family": "Schicktanz", "given": "Felix", "initials": "F"}, {"family": "Sudy", "given": "Alexander", "initials": "A"}, {"family": "Tosti", "given": "Luca", "initials": "L"}, {"family": "van Agen", "given": "Maarten", "initials": "M"}, {"family": "Vandenbempt", "given": "Valerie", "initials": "V"}, {"family": "Avrahami", "given": "Dana", "initials": "D"}, {"family": "Navarro", "given": "Frederic Ballllosera", "initials": "FB"}, {"family": "Bernardo", "given": "Edgar", "initials": "E"}, {"family": "Bj\u00f6rklund", "given": "Frida", "initials": "F"}, {"family": "Chua", "given": "Robert Lorenz", "initials": "RL"}, {"family": "Engelse", "given": "Marten", "initials": "M"}, {"family": "Garc\u00eda-Hurtado", "given": "Javier", "initials": "J"}, {"family": "Groen", "given": "Nathalie", "initials": "N"}, {"family": "Hanegraaf", "given": "Maaike", "initials": "M"}, {"family": "Ia\u00f1ez", "given": "Pablo", "initials": "P"}, {"family": "Jechow", "given": "Katharina", "initials": "K"}, {"family": "Konukiewitz", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Lawerenz", "given": "Christian", "initials": "C"}, {"family": "Lewandowski-Hoppe", "given": "Nadja", "initials": "N"}, {"family": "Marchese", "given": "Domenica", "initials": "D"}, {"family": "Muraro", "given": "Mauro J", "initials": "MJ"}, {"family": "Pellegrini", "given": "Silvia", "initials": "S"}, {"family": "Sordi", "given": "Valeria", "initials": "V"}, {"family": "Taron", "given": "Ulrike", "initials": "U"}, {"family": "Ten", "given": "Foo Wei", "initials": "FW"}, {"family": "Trefzer", "given": "Timo", "initials": "T"}, {"family": "Twardziok", "given": "Sven", "initials": "S"}, {"family": "Wirth", "given": "Johannes", "initials": "J"}, {"family": "Carlotti", "given": "Fran\u00e7oise", "initials": "F"}, {"family": "de Koning", "given": "Eelco", "initials": "E"}, {"family": "Ferrer", "given": "Jorge", "initials": "J"}, {"family": "Glaser", "given": "Benjamin", "initials": "B"}, {"family": "Heyn", "given": "Holger", "initials": "H"}, {"family": "Lundberg", "given": "Emma", "initials": "E"}, {"family": "Piemonti", "given": "Lorenzo", "initials": "L"}, {"family": "Steiger", "given": "Katja", "initials": "K"}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A"}, {"family": "Weichert", "given": "Wilko", "initials": "W"}, {"family": "Conrad", "given": "Christian", "initials": "C"}, {"family": "Eils", "given": "Roland", "initials": "R"}], "type": "journal article", "published": "2026-08-12", "journal": {"title": "Cell Metab.", "issn": "1932-7420", "issn-l": "1550-4131"}, "abstract": "The pancreas plays a central role in major human diseases, yet our understanding of its cellular diversity and plasticity remains incomplete. Here, we present a single-cell multiomics atlas of the human pancreas, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes (T2D). Integrating single-cell RNA sequencing (scRNA-seq)/single-nucleus RNA sequencing (snRNA-seq), snATAC-seq, VASA-seq, spatial transcriptomics (Xenium), and multiplexed proteomics (CODEX), we resolve gene expression, chromatin accessibility, and spatial organization at high resolution. We identify transcriptionally plastic centroacinar-like cells (pCACs) in adults with fetal-like features, delineate endocrine and exocrine lineage trajectories during development, and define HNF1A-defined beta cell epigenetic states. In T2D, we observe shifts in beta cell subtypes and altered regulatory programs. Glucose perturbation of healthy islets reveals cell-type-specific adaptation and stress responses. This atlas provides a foundational framework to understand pancreas biology and the role of cellular plasticity in regeneration and disease.", "doi": "10.1016/j.cmet.2026.07.023", "pmid": "42586061", "labels": {"Spatial Proteomics": "Service"}, "xrefs": [{"db": "pii", "key": "S1550-4131(26)00296-2"}], "notes": [], "created": "2026-08-13T07:03:22.299Z", "modified": "2026-08-13T07:03:22.302Z"}