{"entity": "publication", "iuid": "f75993b5ddc2412188579df68bf81a22", "timestamp": "2026-04-14T08:25:40.471Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f75993b5ddc2412188579df68bf81a22.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f75993b5ddc2412188579df68bf81a22"}}, "title": "Genome-Wide Association Study Identifies That the ABO Blood Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute Coronary Syndrome.", "authors": [{"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Alfredsson", "given": "Jenny", "initials": "J"}, {"family": "Eriksson", "given": "Niclas", "initials": "N"}, {"family": "Wallentin", "given": "Lars", "initials": "L"}, {"family": "Siegbahn", "given": "Agneta", "initials": "A"}], "type": "journal article", "published": "2015-11-24", "journal": {"volume": "10", "issn": "1932-6203", "issue": "11", "pages": "e0142518", "title": "PLoS ONE", "issn-l": "1932-6203"}, "abstract": "Acute coronary syndrome (ACS) is a major cause of mortality worldwide. We have previously shown that increased interleukin-10 (IL-10) levels are associated with poor outcome in ACS patients.\n\nWe performed a genome-wide association study in 2864 ACS patients and 408 healthy controls, to identify genetic variants associated with IL-10 levels. Then haplotype analyses of the identified loci were done and comparisons to levels of IL-10 and other known ACS related biomarkers.\n\nGenetic variants at the ABO blood group locus associated with IL-10 levels (top SNP: rs676457, P = 4.4 \u00d7 10-10) were identified in the ACS patients. Haplotype analysis, using SNPs tagging the four main ABO antigens (A1, A2, B and O), showed that O and A2 homozygous individuals, or O/A2 heterozygotes have much higher levels of IL-10 compared to individuals with other antigen combinations. In the ACS patients, associations between ABO antigens and von Willebrand factor (VWF, P = 9.2 \u00d7 10-13), and soluble tissue factor (sTF, P = 8.6 \u00d7 10-4) were also found. In the healthy control cohort, the associations with VWF and sTF were similar to those in ACS patients (P = 1.2 \u00d7 10-15 and P = 1.0 \u00d7 10-5 respectively), but the healthy cohort showed no association with IL-10 levels (P>0.05). In the ACS patients, the O antigen was also associated with an increased risk of cardiovascular death, all causes of death, and recurrent myocardial infarction (odds ratio [OR] = 1.24-1.29, P = 0.029-0.00067).\n\nOur results suggest that the ABO antigens play important roles, not only for the immunological response in ACS patients, but also for the outcome of the disease.", "doi": "10.1371/journal.pone.0142518", "pmid": "26600159", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "pii", "key": "PONE-D-15-14989"}, {"db": "pmc", "key": "PMC4658192"}], "notes": [], "created": "2017-05-02T12:57:27.891Z", "modified": "2020-01-21T13:56:11.217Z"}