{"entity": "publication", "iuid": "f61c6bdd2de747f392055a5d9c4b6c9a", "timestamp": "2026-08-12T05:48:27.965Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f61c6bdd2de747f392055a5d9c4b6c9a"}}, "title": "Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events.", "authors": [{"family": "Sun", "given": "Jiangming", "initials": "J", "orcid": "0000-0001-6814-1297", "researcher": {"href": "https://publications.scilifelab.se/researcher/358e5b727c9c40ff94848a9d7a8d5945.json"}}, {"family": "Singh", "given": "Pratibha", "initials": "P"}, {"family": "\u00d6sterlund", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications.scilifelab.se/researcher/7e54fbe6f0fc4eed93108b382e1b2952.json"}}, {"family": "Melander", "given": "Olle", "initials": "O", "orcid": "0000-0002-2581-484X", "researcher": {"href": "https://publications.scilifelab.se/researcher/868a7e41aa054097a85575aa1d9658cc.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications.scilifelab.se/researcher/b40c03613a3a46368ed855fc95b79e31.json"}}, {"family": "Edsfeldt", "given": "Andreas", "initials": "A", "orcid": "0000-0002-2691-9192", "researcher": {"href": "https://publications.scilifelab.se/researcher/b4d8310d9d834bd791b791424774b989.json"}}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "volume": "290", "issue": "4", "pages": "855-865", "issn-l": "0954-6820"}, "abstract": "Apoptosis is central in both diabetes and atherosclerosis, linked to pancreatic beta cell death and plaque progression. Circulating Caspase-3 has also been associated with diabetes and coronary calcium score. Here, we explored if soluble Caspase-3 (sCaspase-3) is associated with cardio-metabolic risk factors and predicts incidence of diabetes and coronary artery disease (CAD).\n\nClinical data and plasma from 4637 individuals from the Malm\u00f6 Diet and Cancer cohort were studied. Plasma sCaspase-3 was measured by a Proximity Extension Assay. National registers were used to identify diabetes and CAD events during follow-up. Type 2 diabetes risk variants and expression quantitative trait loci (eQTL) for sCaspase-3 were retrieved from the DIAGRAM consortium and the Genotype-Tissue Expression project.\n\nHbA1c was the factor with the strongest association with sCaspase-3 (r = 0.18, P = 1.3x10-36 ). During follow-up 666 individuals developed diabetes and 648 individuals suffered from CAD. Increasing sCaspase-3 was associated with a higher risk of developing diabetes (hazard ratio (HR) 1.18 per 1unit; P = 7 \u00d7 10-5 ) and CAD (HR 1.2 per 1 unit, P = 1 \u00d7 10-4 ) during follow-up. A genetic variant rs60780116, located upstream of CASP3, showed strong association with type 2 diabetes (OR 1.06, 95%CI 1.04-1.07, P = 8.4 \u00d7 10-11 ). An eQTL was identified between this variant and gene expression of CASP3, where the allele positively correlated with type 2 diabetes was associated with increased CASP3 expression in blood.\n\nThe present study provides evidence for plasma sCaspase-3 as a marker of cardio-metabolic risk factors and as a predictor of future diabetes and CAD in a cohort without cardiovascular disease or diabetes at baseline.", "doi": "10.1111/joim.13327", "pmid": "34309093", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2021-12-10T09:10:01.585Z", "modified": "2021-12-10T09:10:01.790Z"}