{"entity": "publication", "iuid": "f4dd6f4e72c44ce79de4a204cb9e576f", "timestamp": "2026-08-14T21:06:05.754Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f4dd6f4e72c44ce79de4a204cb9e576f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f4dd6f4e72c44ce79de4a204cb9e576f"}}, "title": "Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.", "authors": [{"family": "Cuesta-Marti", "given": "Cristina", "initials": "C", "orcid": "0000-0001-5801-9394", "researcher": {"href": "https://publications.scilifelab.se/researcher/baa384b0b54341da8f2fac9a3be4e166.json"}}, {"family": "Ponce-Espa\u00f1a", "given": "Eduardo", "initials": "E", "orcid": "0000-0001-6197-0041", "researcher": {"href": "https://publications.scilifelab.se/researcher/7779d0962b754413bf98bf72df3c6f61.json"}}, {"family": "Uhlig", "given": "Friederike", "initials": "F", "orcid": "0000-0001-7441-1951", "researcher": {"href": "https://publications.scilifelab.se/researcher/cda6ce181595476fb905e8a971959470.json"}}, {"family": "Stoltenborg", "given": "Iris", "initials": "I"}, {"family": "Wasiewska", "given": "Luiza A", "initials": "LA"}, {"family": "Kareem", "given": "Lamiah", "initials": "L"}, {"family": "Hedayatpour", "given": "Dara", "initials": "D"}, {"family": "Olavarr\u00eda-Ram\u00edrez", "given": "Loreto", "initials": "L"}, {"family": "Rosell-Cardona", "given": "Cristina", "initials": "C", "orcid": "0000-0003-3627-9413", "researcher": {"href": "https://publications.scilifelab.se/researcher/0c9cea7c6c1d4545a15ee0cd9b703ce5.json"}}, {"family": "Bastiaanssen", "given": "Thomaz F S", "initials": "TFS", "orcid": "0000-0001-6891-734X", "researcher": {"href": "https://publications.scilifelab.se/researcher/08055799d14e4bbd85a416143fa065a8.json"}}, {"family": "Tofani", "given": "Gabriel S S", "initials": "GSS", "orcid": "0009-0008-5140-1628", "researcher": {"href": "https://publications.scilifelab.se/researcher/005f2680b1cc42bcac7d0cf7ef10abcd.json"}}, {"family": "Valderrama", "given": "Benjamin", "initials": "B"}, {"family": "Vlckova", "given": "Klara", "initials": "K"}, {"family": "Dickson", "given": "Suzanne L", "initials": "SL"}, {"family": "Lavelle", "given": "Aonghus", "initials": "A"}, {"family": "Stanton", "given": "Catherine", "initials": "C", "orcid": "0000-0002-6724-7011", "researcher": {"href": "https://publications.scilifelab.se/researcher/2a59c196549c4625a3f9c6a3ced9da9c.json"}}, {"family": "Ross", "given": "R Paul", "initials": "RP", "orcid": "0000-0003-4876-8839", "researcher": {"href": "https://publications.scilifelab.se/researcher/14f7fc4e0f094aafaee64d2c3af894b3.json"}}, {"family": "Cryan", "given": "John F", "initials": "JF", "orcid": "0000-0001-5887-2723", "researcher": {"href": "https://publications.scilifelab.se/researcher/ef7ae90db89f49d88cc0faa058709615.json"}}, {"family": "Dinan", "given": "Timothy G", "initials": "TG", "orcid": "0000-0002-2316-7220", "researcher": {"href": "https://publications.scilifelab.se/researcher/89397a01761945b99d2b12569330cfca.json"}}, {"family": "Clarke", "given": "Gerard", "initials": "G", "orcid": "0000-0001-9771-3979", "researcher": {"href": "https://publications.scilifelab.se/researcher/498e0de5b9094934a529b60992ff093c.json"}}, {"family": "O'Mahony", "given": "Siobhain M", "initials": "SM"}, {"family": "Schellekens", "given": "Harri\u00ebt", "initials": "H", "orcid": "0000-0002-6065-3797", "researcher": {"href": "https://publications.scilifelab.se/researcher/fd4d0977b2c34cd98a15e6b65acdffa7.json"}}], "type": "journal article", "published": "2026-02-24", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "17", "issue": "1", "issn-l": "2041-1723"}, "abstract": "An unhealthy diet disrupts feeding behavior and the gut microbiota, but whether early-life dietary effects persist, or can be restored later in life, remains unclear. We investigated whether microbiota-targeted interventions (FOS + GOS or Bifidobacterium longum APC1472) could restore early-life high-fat/high-sugar (HFHS) diet-induced feeding alterations in adult female and male mice. HFHS exposure exclusively in early-life induced persistent, sex-specific feeding alterations in adult mice, despite normalized body weight. Early-life HFHS diet reduced hypothalamic cells expressing feeding-related markers (POMC, GHSR, PNOC, NOD2) in adult mice. Females were more vulnerable, with reduced LEPR+ cells and disrupted arginine/tryptophan metabolism, while males showed impaired peptidoglycan sensing and steroid metabolism. We show that microbiota interventions restore these effects via distinct mechanisms. FOS + GOS induced extensive microbiome compositional shifts and sex-specific restoration of gut-brain pathways, while B. longum APC1472 induced greater behavioral restoration with minimal microbiome compositional changes. These findings highlight sex-specific vulnerabilities and mechanism-dependent therapeutic potential of microbiota-based interventions after exposure to early-life unhealthy diets.", "doi": "10.1038/s41467-026-68968-2", "pmid": "41735265", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12932662"}, {"db": "pii", "key": "10.1038/s41467-026-68968-2"}], "notes": [], "created": "2026-08-11T10:49:43.217Z", "modified": "2026-08-11T10:49:44.298Z"}