{"entity": "publication", "iuid": "f35cd2684e224b08986247b4b2b76ef7", "timestamp": "2026-04-14T09:45:45.751Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/f35cd2684e224b08986247b4b2b76ef7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/f35cd2684e224b08986247b4b2b76ef7"}}, "title": "Targeted proteomic analysis of habitual coffee consumption.", "authors": [{"family": "Cornelis", "given": "M C", "initials": "MC", "orcid": "0000-0002-0699-1664", "researcher": {"href": "https://publications.scilifelab.se/researcher/1755f50af84841d2a7e836f159e2494c.json"}}, {"family": "Gustafsson", "given": "S", "initials": "S"}, {"family": "\u00c4rnl\u00f6v", "given": "J", "initials": "J"}, {"family": "Elmst\u00e5hl", "given": "S", "initials": "S"}, {"family": "S\u00f6derberg", "given": "S", "initials": "S"}, {"family": "Sundstr\u00f6m", "given": "J", "initials": "J"}, {"family": "Micha\u00eblsson", "given": "K", "initials": "K"}, {"family": "Lind", "given": "L", "initials": "L"}, {"family": "Ingelsson", "given": "E", "initials": "E", "orcid": "0000-0003-2256-6972", "researcher": {"href": "https://publications.scilifelab.se/researcher/689bc741ea6547d18de7080c84d0193e.json"}}], "type": "journal article", "published": "2018-02-00", "journal": {"title": "J. Intern. Med.", "issn": "1365-2796", "issn-l": "0954-6820", "volume": "283", "issue": "2", "pages": "200-211"}, "abstract": "Coffee drinking has been implicated in mortality and a variety of diseases but potential mechanisms underlying these associations are unclear. Large-scale systems epidemiological approaches may offer novel insights to mechanisms underlying associations of coffee with health.\n\nWe performed an analysis of known and novel protein markers linked to cardiovascular disease and their association with habitual coffee intake in the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS, n = 816) and followed up top proteins in the Uppsala Longitudinal Study of Adult Men (ULSAM, n = 635) and EpiHealth (n = 2418).\n\nIn PIVUS and ULSAM, coffee intake was measured by 7-day dietary records whilst a computer-based food frequency questionnaire was used in EpiHealth. Levels of up to 80 proteins were assessed in plasma by a proximity extension assay.\n\nFour protein-coffee associations adjusted for age, sex, smoking and BMI, met statistical significance in PIVUS (FDR < 5%, P < 2.31 \u00d7 10-3 ): leptin (LEP), chitinase-3-like protein 1 (CHI3L), tumour necrosis factor (TNF) receptor 6 and TNF-related apoptosis-inducing ligand. The inverse association between coffee intake and LEP replicated in ULSAM (\u03b2, -0.042 SD per cup of coffee, P = 0.028) and EpiHealth (\u03b2, -0.025 SD per time of coffee, P = 0.004). The negative coffee-CHI3L association replicated in EpiHealth (\u03b2, -0.07, P = 1.15 \u00d7 10-7 ), but not in ULSAM (\u03b2, -0.034, P = 0.16).\n\nThe current study supports an inverse association between coffee intake and plasma LEP and CHI3L1 levels. The coffee-CHI3L1 association is novel and warrants further investigation given links between CHI3L1 and health conditions that are also potentially influenced by coffee.", "doi": "10.1111/joim.12703", "pmid": "29044854", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [], "notes": [], "created": "2017-10-31T09:58:47.864Z", "modified": "2023-04-14T13:56:07.465Z"}