{"entity": "publication", "iuid": "ee2e0ed6e5fc4e969acfc7bd207dfefe", "timestamp": "2026-08-07T18:42:21.405Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ee2e0ed6e5fc4e969acfc7bd207dfefe.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ee2e0ed6e5fc4e969acfc7bd207dfefe"}}, "title": "Progenitor exhausted PD-1+ T cells are cellular targets of immune checkpoint inhibition in atherosclerosis.", "authors": [{"family": "Mulholland", "given": "Megan", "initials": "M", "orcid": "0000-0002-3352-0403", "researcher": {"href": "https://publications.scilifelab.se/researcher/332a484487504958849ef563550cd8a0.json"}}, {"family": "Chalou", "given": "Anthi", "initials": "A", "orcid": "0009-0008-4969-3262", "researcher": {"href": "https://publications.scilifelab.se/researcher/5294de2282b44506977b10f1f8da6f47.json"}}, {"family": "Andersson", "given": "Samuel H A", "initials": "SHA", "orcid": "0009-0009-7497-9403", "researcher": {"href": "https://publications.scilifelab.se/researcher/863588877fc848ca96ba6b2e66c9086a.json"}}, {"family": "Depuydt", "given": "Marie A C", "initials": "MAC", "orcid": "0000-0002-7174-1952", "researcher": {"href": "https://publications.scilifelab.se/researcher/1725c990029e403fb7b0c228b112f418.json"}}, {"family": "Yu", "given": "Yinda", "initials": "Y"}, {"family": "Lin", "given": "Shiying", "initials": "S"}, {"family": "Tallb\u00e4ck", "given": "Klara", "initials": "K", "orcid": "0009-0009-4506-6330", "researcher": {"href": "https://publications.scilifelab.se/researcher/1210f8d35a2d480d839300492143a8bc.json"}}, {"family": "Ericsson", "given": "Astrid", "initials": "A"}, {"family": "Jakobsson", "given": "Gabriel", "initials": "G", "orcid": "0000-0001-5071-9505", "researcher": {"href": "https://publications.scilifelab.se/researcher/99f0995b89884f6eb8d33e0e51c33800.json"}}, {"family": "de Mol", "given": "Jill", "initials": "J", "orcid": "0000-0003-3541-9912", "researcher": {"href": "https://publications.scilifelab.se/researcher/7c34c673397547b4bcecf3994d44882a.json"}}, {"family": "Kryvokhyzha", "given": "Dmytro", "initials": "D"}, {"family": "Lichtman", "given": "Andrew H", "initials": "AH", "orcid": "0000-0002-3546-058X", "researcher": {"href": "https://publications.scilifelab.se/researcher/c22011616511413b8c9f22be31a1f951.json"}}, {"family": "Foks", "given": "Amanda C", "initials": "AC", "orcid": "0000-0002-9747-3458", "researcher": {"href": "https://publications.scilifelab.se/researcher/d6713b7fbb8942bea6789bc4e07d575c.json"}}, {"family": "Schiopu", "given": "Alexandru", "initials": "A", "orcid": "0000-0002-7587-5050", "researcher": {"href": "https://publications.scilifelab.se/researcher/c7d2edf9030a445583f692dc4d884b7f.json"}}, {"family": "Bj\u00f6rkbacka", "given": "Harry", "initials": "H", "orcid": "0000-0003-3918-0857", "researcher": {"href": "https://publications.scilifelab.se/researcher/9f4c07bc840f491d843f67a9932d5f3a.json"}}, {"family": "Sl\u00fctter", "given": "Bram", "initials": "B", "orcid": "0000-0003-3996-0503", "researcher": {"href": "https://publications.scilifelab.se/researcher/aa4acafdcb714986a064c0c0369bd4f8.json"}}, {"family": "Gister\u00e5", "given": "Anton", "initials": "A", "orcid": "0000-0002-4614-8030", "researcher": {"href": "https://publications.scilifelab.se/researcher/3e2beec3559745a6ba1859252df4a547.json"}}, {"family": "Engelbertsen", "given": "Daniel", "initials": "D", "orcid": "0000-0002-0289-5210", "researcher": {"href": "https://publications.scilifelab.se/researcher/fc4f0e42f9444337adb276360c27c5cc.json"}}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "Nat Cardiovasc Res", "issn": "2731-0590", "volume": "4", "issue": "10", "pages": "1311-1328", "issn-l": null}, "abstract": "Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1+ T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1intSlamf6+Tim3-), produce IFN\u03b3 in vivo, exhibit signs of recent proliferation and maintain polyfunctionality. PD-1 blockade induced marked changes in plaque immune phenotype, with increased PD-1high T cell accumulation, IFN\u03b3 production, formation of lymphocyte foci and neutrophil recruitment. Depletion of PD-1high T cells prior to PD-1 blockade did not impede T cell recruitment, suggesting a role for progenitor exhausted PD-1int T cells in ICI-driven T cell plaque accumulation. Human circulating PD-1+ T cells produced IFN\u03b3 and were associated with subclinical coronary atherosclerosis. Our studies highlight IFN\u03b3-producing PD-1+ T cells as a potential key immune cell population mediating increased cardiovascular risk in patients with cancer receiving ICI.", "doi": "10.1038/s44161-025-00713-2", "pmid": "41057609", "labels": {"Clinical Genomics Lund": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC12520982"}, {"db": "pii", "key": "10.1038/s44161-025-00713-2"}], "notes": [], "created": "2025-11-06T09:28:37.756Z", "modified": "2025-11-06T09:28:38.934Z"}