{"entity": "publication", "iuid": "dfc6452e87c54ae4a5a175da905f3a44", "timestamp": "2026-07-15T22:24:57.022Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dfc6452e87c54ae4a5a175da905f3a44.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dfc6452e87c54ae4a5a175da905f3a44"}}, "title": "Expression of CD226 is associated to but not required for NK cell education.", "authors": [{"family": "Wagner", "given": "Arnika K", "initials": "AK"}, {"family": "Kadri", "given": "Nadir", "initials": "N"}, {"family": "Sn\u00e4ll", "given": "Johanna", "initials": "J"}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications.scilifelab.se/researcher/40097353cdb24e52bf2330eb687042bf.json"}}, {"family": "Gilfillan", "given": "Susan", "initials": "S"}, {"family": "Colonna", "given": "Marco", "initials": "M"}, {"family": "Bernhardt", "given": "G\u00fcnter", "initials": "G"}, {"family": "H\u00f6glund", "given": "Petter", "initials": "P"}, {"family": "K\u00e4rre", "given": "Klas", "initials": "K"}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ"}], "type": "journal article", "published": "2017-05-31", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "8", "issue": null, "pages": "15627"}, "abstract": "DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory receptors control NK-cell activation and are necessary for MHC-I-dependent education, we investigated whether DNAM-1 expression is also involved in NK-cell education. Here we show an MHC-I-dependent correlation between DNAM-1 expression and NK-cell education, and an association between DNAM-1 and NKG2A that occurs even in MHC class I deficient mice. DNAM-1 is expressed early during NK-cell development, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-dependent fashion. Cd226-/- mice have missing self-responses and NK cells with a normal receptor repertoire. We propose a model in which NK-cell education prevents or delays downregulation of DNAM-1. This molecule endows educated NK cells with enhanced effector functions but is dispensable for education.", "doi": "10.1038/ncomms15627", "pmid": "28561023", "labels": {"Cellular Immunomonitoring": "Collaborative"}, "xrefs": [{"db": "pii", "key": "ncomms15627"}, {"db": "pmc", "key": "PMC5460037"}], "notes": [], "created": "2019-03-25T19:57:01.145Z", "modified": "2023-11-28T12:54:23.964Z"}