{"entity": "publication", "iuid": "df880e2368024d3186c599e61cf01f8a", "timestamp": "2026-06-10T21:31:52.949Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/df880e2368024d3186c599e61cf01f8a.json"}, "display": {"href": "https://publications.scilifelab.se/publication/df880e2368024d3186c599e61cf01f8a"}}, "title": "ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.", "authors": [{"family": "Zhang", "given": "Yi", "initials": "Y"}, {"family": "Xie", "given": "Guojia", "initials": "G", "orcid": "0000-0002-8250-6157", "researcher": {"href": "https://publications.scilifelab.se/researcher/7ec90bde6e0a474f927615602734cd4c.json"}}, {"family": "Lee", "given": "Ji-Eun", "initials": "JE", "orcid": "0000-0002-3768-7016", "researcher": {"href": "https://publications.scilifelab.se/researcher/6b9ee3b2ab77440c80566ad35fc02924.json"}}, {"family": "Zandian", "given": "Mohamad", "initials": "M", "orcid": "0000-0002-4967-6867", "researcher": {"href": "https://publications.scilifelab.se/researcher/2f81558cc5d546f0bbb8b9db1456bc14.json"}}, {"family": "Sudarshan", "given": "Deepthi", "initials": "D"}, {"family": "Estavoyer", "given": "Benjamin", "initials": "B"}, {"family": "Benz", "given": "Caroline", "initials": "C", "orcid": "0000-0002-5166-3598", "researcher": {"href": "https://publications.scilifelab.se/researcher/86628e15252f4dd98f08759d59fad848.json"}}, {"family": "Viita", "given": "Tiina", "initials": "T"}, {"family": "Asgaritarghi", "given": "Golareh", "initials": "G"}, {"family": "Lachance", "given": "Catherine", "initials": "C"}, {"family": "Messmer", "given": "Cl\u00e9mence", "initials": "C"}, {"family": "Simonetti", "given": "Leandro", "initials": "L", "orcid": "0000-0003-1283-9770", "researcher": {"href": "https://publications.scilifelab.se/researcher/23530c1a3cef4f499a460ac59c674261.json"}}, {"family": "Sinha", "given": "Vikrant Kumar", "initials": "VK"}, {"family": "Lambert", "given": "Jean-Philippe", "initials": "JP", "orcid": "0000-0002-0833-1221", "researcher": {"href": "https://publications.scilifelab.se/researcher/ea53138c672d469295549d26672f2e26.json"}}, {"family": "Chen", "given": "Yu-Wen", "initials": "YW"}, {"family": "Wang", "given": "Shu-Ping", "initials": "SP", "orcid": "0000-0002-5895-1269", "researcher": {"href": "https://publications.scilifelab.se/researcher/bd9023a2623140319f7e298758b186e1.json"}}, {"family": "Ivarsson", "given": "Ylva", "initials": "Y", "orcid": "0000-0002-7081-3846", "researcher": {"href": "https://publications.scilifelab.se/researcher/f51534acce8c4214a55a3e7387850d53.json"}}, {"family": "Affar", "given": "El Bachir", "initials": "EB", "orcid": "0000-0002-6374-3683", "researcher": {"href": "https://publications.scilifelab.se/researcher/1acebd04acd94e199bebe57a10db34ff.json"}}, {"family": "C\u00f4t\u00e9", "given": "Jacques", "initials": "J", "orcid": "0000-0001-6751-555X", "researcher": {"href": "https://publications.scilifelab.se/researcher/a4db696aa49342a0b1d9c0efb38c899c.json"}}, {"family": "Ge", "given": "Kai", "initials": "K"}, {"family": "Kutateladze", "given": "Tatiana G", "initials": "TG", "orcid": "0000-0001-7375-6990", "researcher": {"href": "https://publications.scilifelab.se/researcher/4f6b888607504d27b88684a37f4087b9.json"}}], "type": "journal article", "published": "2024-06-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "4883", "issn-l": "2041-1723"}, "abstract": "The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers. Here, we report a novel function of the PHD2 and PHD3 (PHD2/3) fingers of MLL4 and MLL3 that bind to ASXL2, a component of the Polycomb repressive H2AK119 deubiquitinase (PR-DUB) complex. The structure of MLL4 PHD2/3 in complex with the MLL-binding helix (MBH) of ASXL2 and mutational analyses reveal the molecular mechanism which is conserved in homologous ASXL1 and ASXL3. The native interaction of the Trithorax MLL3/4 complexes with the PR-DUB complex in vivo depends solely on MBH of ASXL1/2, coupling the two histone modifying activities. ChIP-seq analysis in embryonic stem cells demonstrates that MBH of ASXL1/2 is required for the deubiquitinase BAP1 recruitment to MLL4-bound active enhancers. Our findings suggest an ASXL1/2-dependent functional link between the MLL3/4 and PR-DUB complexes.", "doi": "10.1038/s41467-024-49391-x", "pmid": "38849395", "labels": {"NGI Short read": "Service", "NGI Stockholm (Genomics Production)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11161652"}, {"db": "pii", "key": "10.1038/s41467-024-49391-x"}], "notes": [], "created": "2024-08-15T12:13:00.466Z", "modified": "2024-10-01T09:33:16.920Z"}