{"entity": "publication", "iuid": "dc5ca47aafbe40018e69f95890ca6181", "timestamp": "2026-10-12T02:39:28.767Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/dc5ca47aafbe40018e69f95890ca6181.json"}, "display": {"href": "https://publications.scilifelab.se/publication/dc5ca47aafbe40018e69f95890ca6181"}}, "title": "Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005-2019.", "authors": [{"family": "Gianecini", "given": "Ricardo Ariel", "initials": "RA"}, {"family": "Poklepovich", "given": "Tomas", "initials": "T"}, {"family": "Golparian", "given": "Daniel", "initials": "D"}, {"family": "Cuenca", "given": "Noelia", "initials": "N"}, {"family": "Tuduri", "given": "Ezequiel", "initials": "E"}, {"family": "Unemo", "given": "Magnus", "initials": "M"}, {"family": "Campos", "given": "Josefina", "initials": "J"}, {"family": "Galarza", "given": "Patricia", "initials": "P"}, {"family": "Gonococcal Antimicrobial Susceptibility Surveillance Programme\u2014Argentina1", "given": "", "initials": ""}], "type": "journal article", "published": "2021-08-24", "journal": {"title": "Emerg. Infect. Dis.", "issn": "1080-6059", "issn-l": "1080-6040", "volume": "27", "issue": "9", "pages": "2369-2378"}, "abstract": "Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015-2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005-2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015-November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2-4 \u03bcg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2-4 or >256 \u03bcg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina.", "doi": "10.3201/eid2709.204843", "pmid": "34424175", "labels": {"Clinical Genomics \u00d6rebro": "Collaborative", "Clinical Genomics": "Collaborative"}, "xrefs": [{"db": "pmc", "key": "PMC8386799"}], "notes": [], "created": "2021-12-08T10:02:40.536Z", "modified": "2021-12-08T12:26:38.448Z"}