{"entity": "publication", "iuid": "d8c307b538944e43b439658ee0a24270", "timestamp": "2026-07-20T16:03:13.096Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d8c307b538944e43b439658ee0a24270.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d8c307b538944e43b439658ee0a24270"}}, "title": "Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.", "authors": [{"family": "Laur\u00e9n", "given": "Ida", "initials": "I", "orcid": "0000-0003-0041-6084", "researcher": {"href": "https://publications.scilifelab.se/researcher/37ecae2143cf4534935defaca37e85ca.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Ng", "given": "Henry", "initials": "H", "orcid": "0000-0003-2873-9088", "researcher": {"href": "https://publications.scilifelab.se/researcher/5fcb12c664a64724b5cd42a1267a5bea.json"}}, {"family": "Lord", "given": "Martin", "initials": "M"}, {"family": "Pettke", "given": "Aleksandra", "initials": "A"}, {"family": "Greilert-Norin", "given": "Nina", "initials": "N"}, {"family": "Gabrielsson", "given": "Lena", "initials": "L"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Amo\u00eado-Leite", "given": "Catarina", "initials": "C"}, {"family": "Josyula", "given": "Vijay S", "initials": "VS"}, {"family": "Eltahir", "given": "Mohamed", "initials": "M"}, {"family": "Kerzeli", "given": "Iliana", "initials": "I"}, {"family": "Falk", "given": "August J", "initials": "AJ", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications.scilifelab.se/researcher/fe6400bde68b46899515cef5bea05fca.json"}}, {"family": "Hober", "given": "Jonathan", "initials": "J"}, {"family": "Christ", "given": "Wanda", "initials": "W"}, {"family": "Wiberg", "given": "Anna", "initials": "A"}, {"family": "Hedhammar", "given": "My", "initials": "M"}, {"family": "Tegel", "given": "Hanna", "initials": "H"}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Xu", "given": "Feifei", "initials": "F"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A"}, {"family": "Klingstr\u00f6m", "given": "Jonas", "initials": "J"}, {"family": "Christoffersson", "given": "Gustaf", "initials": "G"}, {"family": "Hober", "given": "Sophia", "initials": "S"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Philipson", "given": "Mia", "initials": "M"}, {"family": "D\u00f6nnes", "given": "Pierre", "initials": "P"}, {"family": "Lindsay", "given": "Robin", "initials": "R"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C"}, {"family": "Mangsbo", "given": "Sara", "initials": "S", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications.scilifelab.se/researcher/c743bbcad6554f049c8fc5f64a6801bc.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Immun Inflamm Dis", "issn": "2050-4527", "volume": "10", "issue": "4", "pages": "e595", "issn-l": null}, "abstract": "Cellular immune memory responses post coronavirus disease 2019 (COVID-19) have been difficult to assess due to the risks of contaminating the immune response readout with memory responses stemming from previous exposure to endemic coronaviruses. The work herein presents a large-scale long-term follow-up study investigating the correlation between symptomology and cellular immune responses four to five months post seroconversion based on a unique severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific peptide pool that contains no overlapping peptides with endemic human coronaviruses.\n\nPeptide stimulated memory T cell responses were assessed with dual interferon-gamma (IFN\u03b3) and interleukin (IL)-2 Fluorospot. Serological analyses were performed using a multiplex antigen bead array.\n\nOur work demonstrates that long-term SARS-CoV-2-specific memory T cell responses feature dual IFN\u03b3 and IL-2 responses, whereas cross-reactive memory T cell responses primarily generate IFN\u03b3 in response to SARS-CoV-2 peptide stimulation. T cell responses correlated to long-term humoral immune responses. Disease severity as well as specific COVID-19 symptoms correlated with the magnitude of the SARS-CoV-2-specific memory T cell response four to five months post seroconversion.\n\nUsing a large cohort and a SARS-CoV-2-specific peptide pool we were able to substantiate that initial disease severity and symptoms correlate with the magnitude of the SARS-CoV-2-specific memory T cell responses.", "doi": "10.1002/iid3.595", "pmid": "35349756", "labels": {"Autoimmunity and Serology Profiling": "Collaborative"}, "xrefs": [], "notes": [], "created": "2022-03-31T06:07:11.524Z", "modified": "2022-03-31T06:07:11.636Z"}