{"entity": "publication", "iuid": "d6234b6e336845bfaf21a038c009dabd", "timestamp": "2026-08-10T22:57:41.292Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d6234b6e336845bfaf21a038c009dabd.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d6234b6e336845bfaf21a038c009dabd"}}, "title": "The Gly82Ser polymorphism in the receptor for advanced glycation endproducts increases the risk for coronary events in the general population.", "authors": [{"family": "Grauen Larsen", "given": "Helena", "initials": "H"}, {"family": "Sun", "given": "Jiangming", "initials": "J"}, {"family": "Sj\u00f6gren", "given": "Marketa", "initials": "M"}, {"family": "Born\u00e9", "given": "Yan", "initials": "Y"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Schiopu", "given": "Alexandru", "initials": "A"}], "type": "journal article", "published": "2024-05-21", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "14", "issue": "1", "pages": "11567", "issn-l": "2045-2322"}, "abstract": "The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse coronary events (MACE) in the general population. We performed a genome-wide association study to identify genetic determinants of plasma sRAGE in 4338 individuals from the cardiovascular arm of the Malm\u00f6 Diet and Cancer study (MDC-CV). Further, we explored the associations between these genetic variants, incident first-time MACE and mortality in 24,640 unrelated individuals of European ancestry from the MDC cohort. The minor alleles of four single nucleotide polymorphisms (SNPs): rs2070600, rs204993, rs116653040, and rs7306778 were independently associated with lower plasma sRAGE. The minor T (vs. C) allele of rs2070600 was associated with increased risk for MACE [HR 1.13 95% CI (1.02-1.25), P = 0.016]. Neither SNP was associated with mortality. This is the largest study to demonstrate a link between a genetic sRAGE determinant and CV risk. Only rs2070600, which enhances RAGE function by inducing a Gly82Ser polymorphism in the ligand-binding domain, was associated with MACE. The lack of associations with incident MACE for the other sRAGE-lowering SNPs suggests that this functional RAGE modification is central for the observed relationship.", "doi": "10.1038/s41598-024-62385-5", "pmid": "38773223", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC11109115"}, {"db": "pii", "key": "10.1038/s41598-024-62385-5"}], "notes": [], "created": "2024-11-27T22:22:31.609Z", "modified": "2024-11-27T22:22:31.630Z"}