{"entity": "publication", "iuid": "d604787528614bb3a9cbc37e395c350b", "timestamp": "2026-07-15T22:46:04.381Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d604787528614bb3a9cbc37e395c350b.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d604787528614bb3a9cbc37e395c350b"}}, "title": "Sacrificial redox modulation by a secreted bacterial effector molecule mitigates oxidative stress and inflammation in vivo.", "authors": [{"family": "Andersson", "given": "Tilde", "initials": "T"}, {"family": "Anwaar", "given": "Shoaib", "initials": "S"}, {"family": "Fuentes-Lemus", "given": "Eduardo", "initials": "E"}, {"family": "Allhorn", "given": "Maria", "initials": "M"}, {"family": "Happonen", "given": "Lotta", "initials": "L"}, {"family": "Veitch", "given": "Margaret", "initials": "M"}, {"family": "Chew", "given": "Hui Yi", "initials": "HY"}, {"family": "Montes de Oca", "given": "Marcela", "initials": "M"}, {"family": "Tanner", "given": "Lloyd", "initials": "L"}, {"family": "Br\u00fcggemann", "given": "Holger", "initials": "H"}, {"family": "Nordenfelt", "given": "Pontus", "initials": "P"}, {"family": "Davies", "given": "Michael J", "initials": "MJ"}, {"family": "Wells", "given": "James W", "initials": "JW"}, {"family": "Lood", "given": "Rolf", "initials": "R"}], "type": "journal article", "published": "2025-12-01", "journal": {"title": "Free Radic. Biol. Med.", "issn": "1873-4596", "volume": "240", "pages": "339-346", "issn-l": "0891-5849"}, "abstract": "Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural mapping, biophysical binding studies, and in vivo experiments, we demonstrate how RoxP contributes to skin homeostasis by serving as a target for oxidative attack and influencing cytokine signaling. To our knowledge, this is the first in vivo mechanistic description of a secreted prokaryotic effector molecule modulating host redox balance through sacrificial oxidation, providing evidence of its role as a health-promoting factor.", "doi": "10.1016/j.freeradbiomed.2025.08.038", "pmid": "40849000", "labels": {"Structural Proteomics": "Collaborative"}, "xrefs": [{"db": "pii", "key": "S0891-5849(25)00925-6"}], "notes": [], "created": "2025-11-28T10:24:46.777Z", "modified": "2025-11-28T10:24:46.787Z"}