{"entity": "publication", "iuid": "d58af9ba1de74613a0bfe17735254232", "timestamp": "2026-06-10T16:12:14.717Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d58af9ba1de74613a0bfe17735254232.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d58af9ba1de74613a0bfe17735254232"}}, "title": "A chemical screen underscores the essential role of STAT1-dependent IFN\u03b3 signaling to regulate HLA-I expression in cancer cells.", "authors": [{"family": "Barz", "given": "Myriam", "initials": "M"}, {"family": "Porebski", "given": "Bartlomiej", "initials": "B"}, {"family": "Panshikar", "given": "Pranauti", "initials": "P"}, {"family": "H\u00e4ggbladd", "given": "Maria", "initials": "M"}, {"family": "H\u00fchn", "given": "Daniela", "initials": "D"}, {"family": "Fernandez-Capetillo", "given": "Oscar", "initials": "O"}], "type": "journal article", "published": "2023-01-18", "journal": {"title": "MicroPubl Biol", "issn": "2578-9430", "volume": "2023", "issn-l": null}, "abstract": "The presentation of neoantigens by HLA-I is essential for the recognition of tumor cells by cytotoxic T cells. Transcriptionally, HLA-I expression is regulated by interferon-dependent activation of JAK/STAT signaling. Accordingly, mutations that inactivate this pathway are one of the main causes of resistance to cancer immunotherapies. Recent evidences indicate that HLA-I expression can be induced independently of IFN-signaling by the innate immune response. In this context, we performed an image-based screen to evaluate how more than 5,000 chemicals, including all medically available drugs plus many others in advanced preclinical development, influence HLA-I expression in STAT1-deficient cells. Our screening failed to identify any significant hits, suggesting that drug-dependent modulation of HLA-I expression is strictly dependent on IFN-signaling.", "doi": "10.17912/micropub.biology.000697", "pmid": "36743451", "labels": {"Chemical Biology Consortium Sweden": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9892930"}], "notes": [], "created": "2023-10-18T18:50:12.211Z", "modified": "2025-10-17T13:04:27.698Z"}