{"entity": "publication", "iuid": "d0616eabc7bf4c6e827bfb5db26c2bc5", "timestamp": "2026-07-22T14:04:50.570Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/d0616eabc7bf4c6e827bfb5db26c2bc5.json"}, "display": {"href": "https://publications.scilifelab.se/publication/d0616eabc7bf4c6e827bfb5db26c2bc5"}}, "title": "The ESSENCE-Questionnaire in Medical Records Screening for Neurodevelopmental Symptoms/Problems: Utility and Clinical Validity.", "authors": [{"family": "Landgren", "given": "Valdemar", "initials": "V", "orcid": "0000-0003-3249-8221", "researcher": {"href": "https://publications.scilifelab.se/researcher/2a7ae55b2bf2414ea1bb2a73783b89cc.json"}}, {"family": "Raanan Soltis", "given": "Zohar", "initials": "Z"}, {"family": "Svensson", "given": "Emma", "initials": "E"}, {"family": "Theodosiou", "given": "Michail", "initials": "M"}, {"family": "Landgren", "given": "Magnus", "initials": "M"}, {"family": "Knez", "given": "Rajna", "initials": "R", "orcid": "0000-0003-1278-4554", "researcher": {"href": "https://publications.scilifelab.se/researcher/f3508ae4b1c747a4a366c3ab84cf24bb.json"}}], "type": "journal article", "published": "2022-11-03", "journal": {"title": "Neuropsychiatr Dis Treat", "issn": "1178-2021", "issn-l": null, "volume": "18", "issue": null, "pages": "2559-2574"}, "abstract": "Determine the prevalence of symptoms of neurodevelopmental problems (NDPs) with a semi-structured review of fourth grade students' medical records, its interrater agreement and validity as compared with clinical assessment.\r\n\r\nA school-based sample of 11-year-old children provided child health care (CHC) records and school health care (SHC) records. A pediatric neurologist, child psychiatrist and an adult psychiatrist scored the records, with the \"Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations-Questionnaire\" (ESSENCE-Q, 12 items scored 0-2, summary score range 0-24). Agreement was measured with model-based kappa and intraclass correlation coefficient (ICC). Ratings were validated against a multidisciplinary assessment involving a physician, psychologist, teacher- and parental behavioral rating scales rendering a clinical global impression severity rating (CGI-S, range 1-7) of NDPs.\r\n\r\nOut of 223 participants, medical charts were available from 201, of whom 169 were rated by all three raters. Kappa agreement was moderate/strong (~0.8) for 7 of the 12 questionnaire items. Measured with the ICC, concordance in the summary score was good for agreement (~0.8) and excellent (~0.9) for consistency. Test-retest reliability was excellent (ICC = ~0.9). Area under the curve for the ESSENCE-Q in predicting clinical-level problems (CGI \u22654) was ~80% for all three raters, albeit with differing optimal cutoffs.\r\n\r\nUsing the ESSENCE-Q as a template, NDPs appear to be common in medical records, are identified reliably, and predict clinical-level concern. Medical records screening may facilitate a structured review of medical records in work-ups or be applied in conjunction with other screening measures for neurodevelopmental disorders. However, differences in calibration currently preclude defining a universal cutoff for using the ESSENCE-Q for medical records screening.", "doi": "10.2147/NDT.S367196", "pmid": "36353466", "labels": {"Clinical Genomics Gothenburg": "Service", "Clinical Genomics": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC9639423"}, {"db": "pii", "key": "367196"}], "notes": [], "created": "2022-12-02T12:21:18.625Z", "modified": "2024-01-19T11:45:43.640Z"}