{"entity": "publication", "iuid": "ce95be317b604f59aeca4a089d225e99", "timestamp": "2026-08-10T22:58:02.262Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/ce95be317b604f59aeca4a089d225e99.json"}, "display": {"href": "https://publications.scilifelab.se/publication/ce95be317b604f59aeca4a089d225e99"}}, "title": "Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study.", "authors": [{"family": "Zeng", "given": "Yingxu", "initials": "Y"}, {"family": "Mtintsilana", "given": "Asanda", "initials": "A"}, {"family": "Goedecke", "given": "Julia H", "initials": "JH"}, {"family": "Micklesfield", "given": "Lisa K", "initials": "LK"}, {"family": "Olsson", "given": "Tommy", "initials": "T"}, {"family": "Chorell", "given": "Elin", "initials": "E", "orcid": "0000-0003-2523-1940", "researcher": {"href": "https://publications.scilifelab.se/researcher/ada783ae0a824621a3b8e1024aae13a4.json"}}], "type": "journal article", "published": "2019-06-00", "journal": {"title": "Metabolism", "issn": "1532-8600", "volume": "95", "issue": null, "pages": "57-64", "issn-l": "0026-0495"}, "abstract": "South Africa (SA) has the highest global projected increase in diabetes risk. Factors typically associated with insulin resistance and type 2 diabetes risk in Caucasians are not significant correlates in black African populations. Therefore, we aimed to identify circulating metabolite patterns that predict type 2 diabetes development in this high-risk, yet understudied SA population.\n\nWe conducted a prospective cohort study in black SA women with normal glucose tolerance (NGT). Participants were followed for 13 years and developed (i) type 2 diabetes (n = 20, NGT-T2D), (ii) impaired glucose tolerance (IGT) (n = 27, NGT-IGT), or (iii) remained NGT (n = 28, NGT-NGT). Mass-spectrometry based metabolomics and multivariate analyses were used to elucidate metabolite patterns at baseline and at follow-up that were associated with type 2 diabetes development.\n\nMetabolites of phospholipid, bile acid and branched-chain amino acid (BCAA) metabolism, differed significantly between the NGT-T2D and NGT-NGT groups. At baseline: the NGT-T2D group had i) a higher lysophosphatidylcholine:lysophosphatidylethanolamine ratio containing linoleic acid (LPC(C18:2):LPE(C18:2)), ii) lower proliferation-related bile acids (ursodeoxycholic- and chenodeoxycholic acid), iii) higher levels of leucine and its catabolic intermediates (ketoleucine and C5-carnitine), compared to the NGT-NGT group. At follow-up: the NGT-T2D group had i) lower LPC(C18:2) levels, ii) higher apoptosis-related bile acids (deoxycholic- and glycodeoxycholic acid), and iii) higher levels of all BCAAs and their catabolic intermediates.\n\nChanges in lysophospholipid metabolism and the bile acid pool occur during the development of type 2 diabetes in black South African women. Further, impaired leucine catabolism precedes valine and isoleucine catabolism in the development of type 2 diabetes. These metabolite patterns can be useful to identify and monitor type 2 diabetes risk >10 years prior to disease onset and provide insight into the pathophysiology of type 2 diabetes in this high risk, but under-studied population.", "doi": "10.1016/j.metabol.2019.04.001", "pmid": "30954560", "labels": {"Swedish Metabolomics Centre": "Service"}, "xrefs": [{"db": "pii", "key": "S0026-0495(19)30067-8"}], "notes": [], "created": "2020-01-07T15:49:27.105Z", "modified": "2025-10-17T13:03:17.571Z"}