{"entity": "publication", "iuid": "c719331cfa39445caac67f21fcf18807", "timestamp": "2026-09-12T19:33:19.601Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c719331cfa39445caac67f21fcf18807.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c719331cfa39445caac67f21fcf18807"}}, "title": "IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning.", "authors": [{"family": "Layunta", "given": "Elena", "initials": "E"}, {"family": "J\u00e4verfelt", "given": "Sofia", "initials": "S"}, {"family": "Dolan", "given": "Brendan", "initials": "B"}, {"family": "Arike", "given": "Liisa", "initials": "L"}, {"family": "Pelaseyed", "given": "Thaher", "initials": "T"}], "type": "journal article", "published": "2021-02-16", "journal": {"title": "Cell Rep", "issn": "2211-1247", "volume": "34", "issue": "7", "pages": "108757", "issn-l": null}, "abstract": "The intestine is under constant exposure to chemicals, antigens, and microorganisms from the external environment. Apical aspects of transporting epithelial cells (enterocytes) form a brush-border membrane (BBM), shaped by packed microvilli coated with a dense glycocalyx. We present evidence showing that the glycocalyx forms an epithelial barrier that prevents exogenous molecules and live bacteria from gaining access to BBM. We use a multi-omics approach to investigate the function and regulation of membrane mucins exposed on the BBM during postnatal development of the mouse small intestine. Muc17 is identified as a major membrane mucin in the glycocalyx that is specifically upregulated by IL-22 as part of an epithelial defense repertoire during weaning. High levels of IL-22 at time of weaning reprogram neonatal postmitotic progenitor enterocytes to differentiate into Muc17-expressing enterocytes, as found in the adult intestine during homeostasis. Our findings propose a role for Muc17 in epithelial barrier function in the small intestine.", "doi": "10.1016/j.celrep.2021.108757", "pmid": "33596425", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service"}, "xrefs": [{"db": "pii", "key": "S2211-1247(21)00070-X"}], "notes": [], "created": "2023-02-16T08:18:32.334Z", "modified": "2023-02-16T08:18:32.350Z"}