{"entity": "publication", "iuid": "c3dcf2e9bf1d4382866d6a7c7b6018f7", "timestamp": "2026-07-22T14:03:39.053Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/c3dcf2e9bf1d4382866d6a7c7b6018f7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/c3dcf2e9bf1d4382866d6a7c7b6018f7"}}, "title": "The GTPase domain of gamma-tubulin is required for normal mitochondrial function and spatial organization.", "authors": [{"family": "Lindstr\u00f6m", "given": "Lisa", "initials": "L"}, {"family": "Li", "given": "Tongbin", "initials": "T"}, {"family": "Malycheva", "given": "Darina", "initials": "D"}, {"family": "Kancharla", "given": "Arun", "initials": "A"}, {"family": "Nilsson", "given": "Hel\u00e9n", "initials": "H"}, {"family": "Vishnu", "given": "Neelanjan", "initials": "N"}, {"family": "Mulder", "given": "Hindrik", "initials": "H"}, {"family": "Johansson", "given": "Martin", "initials": "M"}, {"family": "Rossell\u00f3", "given": "Catalina Ana", "initials": "CA"}, {"family": "Alvarado-Kristensson", "given": "Maria", "initials": "M", "orcid": "0000-0003-0598-7986", "researcher": {"href": "https://publications.scilifelab.se/researcher/70ee81797eff452fa037821f293d8673.json"}}], "type": "journal article", "published": "2018-05-03", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "1", "issue": "1", "pages": "37", "issn-l": "2399-3642"}, "abstract": "In the cell, \u03b3-tubulin establishes a cellular network of threads named the \u03b3-string meshwork. However, the functions of this meshwork remain to be determined. We investigated the traits of the meshwork and show that \u03b3-strings have the ability to connect the cytoplasm and the mitochondrial DNA together. We also show that \u03b3-tubulin has a role in the maintenance of the mitochondrial network and functions as reduced levels of \u03b3-tubulin or impairment of its GTPase domain disrupts the mitochondrial network and alters both their respiratory capacity and the expression of mitochondrial-related genes. By contrast, reduced mitochondrial number or increased protein levels of \u03b3-tubulin DNA-binding domain enhanced the association of \u03b3-tubulin with mitochondria. Our results demonstrate that \u03b3-tubulin is an important mitochondrial structural component that maintains the mitochondrial network, providing mitochondria with a cellular infrastructure. We propose that \u03b3-tubulin provides a cytoskeletal element that gives form to the mitochondrial network.", "doi": "10.1038/s42003-018-0037-3", "pmid": "30271923", "labels": {"Integrated Microscopy Technologies Gothenburg": "Service", "National Genomics Infrastructure": "Service", "NGI Uppsala (SNP&SEQ Technology Platform)": "Service"}, "xrefs": [{"db": "pii", "key": "10.1038/s42003-018-0037-3"}, {"db": "pmc", "key": "PMC6123723"}], "notes": [], "created": "2020-01-23T16:26:11.434Z", "modified": "2021-11-03T15:41:13.583Z"}