{"entity": "publication", "iuid": "bcd15fd6812c4d539ad51805dfafdbed", "timestamp": "2026-08-12T06:03:20.768Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bcd15fd6812c4d539ad51805dfafdbed.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bcd15fd6812c4d539ad51805dfafdbed"}}, "title": "Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke.", "authors": [{"family": "Berntsson", "given": "John", "initials": "J", "orcid": "0000-0002-3464-5427", "researcher": {"href": "https://publications.scilifelab.se/researcher/d5e93b88f49142feb95ba600d71f66c7.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Johnson", "given": "Linda S B", "initials": "LSB"}, {"family": "S\u00f6derholm", "given": "Martin", "initials": "M"}, {"family": "Born\u00e9", "given": "Yan", "initials": "Y"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}], "type": "journal article", "published": "2019-04-00", "journal": {"title": "Heart", "issn": "1468-201X", "issn-l": "1355-6037", "volume": "105", "issue": "7", "pages": "553-558"}, "abstract": "Vascular endothelial growth factor D (VEGF-D) has important functions in lymphangiogenesis and angiogenesis. High plasma levels of VEGF-D have been associated with incidence of heart failure. The association of VEGF-D with atrial fibrillation (AF) and stroke is unclear and we hypothesised that VEGF-D could also be associated with incidence of AF and ischaemic stroke.\n\nVEGF-D was measured in fasting blood samples of 4689 subjects (40% men) without a history of AF from the Malm\u00f6 Diet and Cancer Study, a prospective, population-based study in Sweden. Median age was 58 years (range 46-68). Cox regression analyses, adjusted for multiple risk factors, was used to assess AF and ischaemic stroke risk in relation to VEGF-D levels.\n\nDuring a median follow-up time of 20.6 years, there were 637 cases of incident AF and 322 cases of first ischaemic stroke. After adjustment, VEGF-D was significantly associated with AF (HR 1.13(95% CI 1.04 to 1.23) per 1 SD increase) and ischaemic stroke (HR 1.14(95% CI 1.02 to 1.28) per 1 SD). The association with ischaemic stroke was explained by an increased incidence of AF-related stroke. HRs per 1 SD were 1.34 (95% CI 1.04 to 1.71) for AF-related ischaemic stroke and 1.04 (95% CI 0.90 to 1.19) for ischaemic stroke without AF.\n\nIncreased VEGF-D concentrations were associated with AF and ischaemic stroke. The relationship with ischaemic stroke was more pronounced in subjects with a diagnosis of AF.", "doi": "10.1136/heartjnl-2018-313684", "pmid": "30327392", "labels": {"Clinical Biomarkers": "Service", "PLA and Single Cell Proteomics": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "heartjnl-2018-313684"}], "notes": [], "created": "2020-01-23T15:57:17.613Z", "modified": "2023-04-14T13:55:58.496Z"}