{"entity": "publication", "iuid": "bb671d846feb4cb5bcdc06ad976fd3b3", "timestamp": "2026-07-18T14:23:54.129Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/bb671d846feb4cb5bcdc06ad976fd3b3.json"}, "display": {"href": "https://publications.scilifelab.se/publication/bb671d846feb4cb5bcdc06ad976fd3b3"}}, "title": "Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation.", "authors": [{"family": "Hlebowicz", "given": "Joanna", "initials": "J"}, {"family": "Holm", "given": "Johan", "initials": "J"}, {"family": "Lindstedt", "given": "Sandra", "initials": "S"}, {"family": "Goncalves", "given": "Isabel", "initials": "I"}, {"family": "Nilsson", "given": "Jan", "initials": "J"}], "type": "journal article", "published": "2021-10-00", "journal": {"title": "Atherosclerosis", "issn": "1879-1484", "volume": "335", "pages": "47-52", "issn-l": "0021-9150"}, "abstract": "After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA.\n\nSixty-four patients with CoA (66% male, mean age 48 \u00b1 15 years) and controls (54% men, mean age 47 \u00b1 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used.\n\nIn men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72-1.24] vs. 0.67 [0.59-0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61-0.97] mm vs. 0.58 [0.53-0.76] mm, p < 0.003) and in women compared to controls (0.83 [0.70-0.92] vs. 0.60 [0.55-0.69], p < 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015).\n\nThis is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.", "doi": "10.1016/j.atherosclerosis.2021.09.016", "pmid": "34564048", "labels": {"Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pii", "key": "S0021-9150(21)01356-3"}, {"db": "ClinicalTrials.gov", "key": "NCT03999073"}], "notes": [], "created": "2021-12-10T10:17:44.986Z", "modified": "2022-12-02T08:54:22.590Z"}