{"entity": "publication", "iuid": "b7f29558b4af4c6f98335230b12d1dc2", "timestamp": "2026-08-10T23:10:57.456Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b7f29558b4af4c6f98335230b12d1dc2.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b7f29558b4af4c6f98335230b12d1dc2"}}, "title": "Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.", "authors": [{"family": "Nettleton", "given": "Jennifer A", "initials": "JA"}, {"family": "McKeown", "given": "Nicola M", "initials": "NM"}, {"family": "Kanoni", "given": "Stavroula", "initials": "S"}, {"family": "Lemaitre", "given": "Rozenn N", "initials": "RN"}, {"family": "Hivert", "given": "Marie-France", "initials": "MF"}, {"family": "Ngwa", "given": "Julius", "initials": "J"}, {"family": "van Rooij", "given": "Frank J A", "initials": "FJ"}, {"family": "Sonestedt", "given": "Emily", "initials": "E"}, {"family": "Wojczynski", "given": "Mary K", "initials": "MK"}, {"family": "Ye", "given": "Zheng", "initials": "Z"}, {"family": "Tanaka", "given": "Tosh", "initials": "T"}, {"family": "Garcia", "given": "Melissa", "initials": "M"}, {"family": "Anderson", "given": "Jennifer S", "initials": "JS"}, {"family": "Follis", "given": "Jack L", "initials": "JL"}, {"family": "Djousse", "given": "Luc", "initials": "L"}, {"family": "Mukamal", "given": "Kenneth", "initials": "K"}, {"family": "Papoutsakis", "given": "Constantina", "initials": "C"}, {"family": "Mozaffarian", "given": "Dariush", "initials": "D"}, {"family": "Zillikens", "given": "M Carola", "initials": "MC"}, {"family": "Bandinelli", "given": "Stefania", "initials": "S"}, {"family": "Bennett", "given": "Amanda J", "initials": "AJ"}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "Feitosa", "given": "Mary F", "initials": "MF"}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Forouhi", "given": "Nita G", "initials": "NG"}, {"family": "Groves", "given": "Christopher J", "initials": "CJ"}, {"family": "Hallmans", "given": "Goran", "initials": "G"}, {"family": "Harris", "given": "Tamara", "initials": "T"}, {"family": "Hofman", "given": "Albert", "initials": "A"}, {"family": "Houston", "given": "Denise K", "initials": "DK"}, {"family": "Hu", "given": "Frank B", "initials": "FB"}, {"family": "Johansson", "given": "Ingegerd", "initials": "I"}, {"family": "Kritchevsky", "given": "Stephen B", "initials": "SB"}, {"family": "Langenberg", "given": "Claudia", "initials": "C"}, {"family": "Launer", "given": "Lenore", "initials": "L"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "Loos", "given": "Ruth J", "initials": "RJ"}, {"family": "Nalls", "given": "Michael", "initials": "M"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Renstrom", "given": "Frida", "initials": "F"}, {"family": "Rice", "given": "Kenneth", "initials": "K"}, {"family": "Riserus", "given": "Ulf", "initials": "U"}, {"family": "Rolandsson", "given": "Olov", "initials": "O"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Saylor", "given": "Georgia", "initials": "G"}, {"family": "Sijbrands", "given": "Eric J G", "initials": "EJ"}, {"family": "Sjogren", "given": "Per", "initials": "P"}, {"family": "Smith", "given": "Albert", "initials": "A"}, {"family": "Steingr\u00edmsd\u00f3ttir", "given": "Laufey", "initials": "L"}, {"family": "Uitterlinden", "given": "Andr\u00e9 G", "initials": "AG"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Prokopenko", "given": "Inga", "initials": "I"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Florez", "given": "Jose C", "initials": "JC"}, {"family": "Witteman", "given": "Jacqueline C M", "initials": "JC"}, {"family": "MAGIC Investigators", "given": null, "initials": null}, {"family": "Dupuis", "given": "Jos\u00e9e", "initials": "J"}, {"family": "Dedoussis", "given": "George V", "initials": "GV"}, {"family": "Ordovas", "given": "Jose M", "initials": "JM"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Cupples", "given": "L Adrienne", "initials": "L"}, {"family": "Siscovick", "given": "David S", "initials": "DS"}, {"family": "Franks", "given": "Paul W", "initials": "PW"}, {"family": "Meigs", "given": "James B", "initials": "JB"}], "type": "journal article", "published": "2010-12-00", "journal": {"volume": "33", "issn": "1935-5548", "issue": "12", "pages": "2684-2691", "title": "Diabetes Care", "issn-l": "0149-5992"}, "abstract": "Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin.\n\nVia meta-analysis of data from 14 cohorts comprising \u223c 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant.\n\nGreater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (\u03b2 [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.\n\nOur results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.", "doi": "10.2337/dc10-1150", "pmid": "20693352", "labels": {"National Genomics Infrastructure": null, "NGI Uppsala (SNP&SEQ Technology Platform)": null}, "xrefs": [{"db": "pii", "key": "dc10-1150"}, {"db": "pmc", "key": "PMC2992213"}], "notes": [], "created": "2017-05-04T15:00:29.536Z", "modified": "2020-01-21T13:56:04.814Z"}