{"entity": "publication", "iuid": "b7e17533eee14fb99c7a12b71c7c780d", "timestamp": "2026-07-05T14:33:54.773Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b7e17533eee14fb99c7a12b71c7c780d.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b7e17533eee14fb99c7a12b71c7c780d"}}, "title": "Retinal tau phosphorylation in Alzheimer's disease: A mass spectrometry study.", "authors": [{"family": "Santiago", "given": "Jessica", "initials": "J"}, {"family": "Pocevi\u010di\u016bt\u0117", "given": "Dovil\u0117", "initials": "D"}, {"family": "Vogel", "given": "Jacob", "initials": "J"}, {"family": "Netherlands Brain Bank", "given": "", "initials": ""}, {"family": "Brinkmalm", "given": "Gunnar", "initials": "G"}, {"family": "Wennstr\u00f6m", "given": "Malin", "initials": "M"}], "type": "journal article", "published": "2025-10-15", "journal": {"title": "Neurobiol. Dis.", "issn": "1095-953X", "volume": "215", "pages": "107057", "issn-l": "0969-9961"}, "abstract": "Most neurodegenerative diseases, including Alzheimer's disease (AD) and multiple sclerosis (MS), feature abnormal tau phosphorylation (p-tau) in the brain. Prior immunostaining studies have shown p-tau accumulation in the AD retina, suggesting it may mirror brain tau pathology.\n\nWe used mass spectrometry to quantify p-tau peptides in matched retinal and hippocampal samples from non-demented controls (NC, n = 8), AD (n = 12), and MS (n = 4). We compared p-tau levels across diagnoses and analysed correlations between retinal p-tau variants, hippocampal p-tau, and neuropathological changes.\n\nTau peptides phosphorylated at T181, S199/S202, T231, T231 + T235, S396 + T403/S404, and T403/S404 were detected in retinas. Total tau phosphorylation and phosphorylation at S199/S202 and T231 were significantly higher in AD cases compared to NC. These two, along with p-tau S396 + T403/S404, were also higher in cases with high amyloid-beta (A\u03b2) Braak stages compared to those with low A\u03b2 Braak stages. Higher A\u03b2 stages were also correlated with higher peak intensities of p-tau S199/S202 and S396 + T403/S404, and retinal p-tau S396 + T403/S404 and T403/S404 correlated with neurofibrillary tangle (NFT) Braak stages. Additionally, p-tau S396 + T403/S404 in the retina was associated with corresponding phosphorylation in the hippocampus.\n\nOur findings reveal both overlapping and distinct p-tau patterns in retina and hippocampus, with a notable link for p-tau S396 + T403/S404. This enhances our understanding of tauopathies in both tissues and supports retinal tau as a promising biomarker for AD diagnosis and monitoring.", "doi": "10.1016/j.nbd.2025.107057", "pmid": "40835172", "labels": {"Clinical Proteomics Lund": "Service"}, "xrefs": [{"db": "pii", "key": "S0969-9961(25)00273-6"}], "notes": [], "created": "2026-07-01T10:56:04.516Z", "modified": "2026-07-01T10:56:04.523Z"}