{"entity": "publication", "iuid": "b32de9be5435484c9597989fb073c05f", "timestamp": "2026-04-14T07:35:23.670Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/b32de9be5435484c9597989fb073c05f.json"}, "display": {"href": "https://publications.scilifelab.se/publication/b32de9be5435484c9597989fb073c05f"}}, "title": "RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells.", "authors": [{"family": "Siaw", "given": "Joachim Tetteh", "initials": "JT"}, {"family": "Claeys", "given": "Arne", "initials": "A"}, {"family": "Lai", "given": "Wei-Yun", "initials": "WY"}, {"family": "Boren\u00e4s", "given": "Marcus", "initials": "M"}, {"family": "Hilgert", "given": "Elien", "initials": "E"}, {"family": "Bekaert", "given": "Sarah-Lee", "initials": "SL"}, {"family": "Sanders", "given": "Ellen", "initials": "E"}, {"family": "Kaya", "given": "Irem", "initials": "I"}, {"family": "Van Dorpe", "given": "Jo", "initials": "J"}, {"family": "Speleman", "given": "Frank", "initials": "F"}, {"family": "Durinck", "given": "Kaat", "initials": "K"}, {"family": "Hallberg", "given": "Bengt", "initials": "B"}, {"family": "Palmer", "given": "Ruth H", "initials": "RH"}, {"family": "Van den Eynden", "given": "Jimmy", "initials": "J"}], "type": "journal article", "published": "2026-04-17", "journal": {"title": "iScience", "issn": "2589-0042", "volume": "29", "issue": "4", "pages": "115236", "issn-l": "2589-0042"}, "abstract": "High-risk neuroblastoma is characterized by MYCN amplification and high MYCN or MYC gene expression. These patients have a poor prognosis and there is an urgent need for more effective drugs. While strategies to develop inhibitors that directly target the MYC proteins have remained largely unsuccessful, recent preclinical studies have identified ATR, a key protein of the DNA damage response, as a promising alternative therapeutic target. Here, we identified a strong RUVBL1 and RUVBL2 signature in transcriptomics data derived from different MYCN-driven mice tumors treated with ATR inhibitors. The RUVBL proteins form a complex with ATPase activity that has broad cellular functions and we demonstrate that pharmacological inhibition of this protein complex results in a strong reduction of MYC(N) signaling, cell-cycle arrest, DNA damage, and apoptosis. We confirmed the association with MYCN and identified the RUVBL genes as independent prognostic biomarkers in human primary neuroblastoma data.", "doi": "10.1016/j.isci.2026.115236", "pmid": "41940329", "labels": {"NGI Stockholm (Genomics Production)": "Service", "NGI Stockholm (Genomics Applications)": "Service", "National Genomics Infrastructure": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC13049659"}, {"db": "pii", "key": "S2589-0042(26)00611-5"}], "notes": [], "created": "2026-04-10T13:11:20.241Z", "modified": "2026-04-10T13:11:20.252Z"}