{"entity": "publication", "iuid": "af902f42fab44b62a2b01a329fd1e915", "timestamp": "2026-07-20T23:02:08.929Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/af902f42fab44b62a2b01a329fd1e915.json"}, "display": {"href": "https://publications.scilifelab.se/publication/af902f42fab44b62a2b01a329fd1e915"}}, "title": "Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.", "authors": [{"family": "Lenart", "given": "Klara", "initials": "K", "orcid": "0000-0002-4984-2618", "researcher": {"href": "https://publications.scilifelab.se/researcher/b2e93a7400934289947153f095273178.json"}}, {"family": "Arcoverde Cerveira", "given": "Rodrigo", "initials": "R", "orcid": "0000-0002-1145-2534", "researcher": {"href": "https://publications.scilifelab.se/researcher/df30915fb0e849609871f5237a33ff2b.json"}}, {"family": "Hellgren", "given": "Fredrika", "initials": "F"}, {"family": "Ols", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-9784-7176", "researcher": {"href": "https://publications.scilifelab.se/researcher/e1343e56a87f49c4abc7beb6f36b87c1.json"}}, {"family": "Sheward", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0002-0227-5636", "researcher": {"href": "https://publications.scilifelab.se/researcher/6105f3617cdf4241bf335299ac957ee5.json"}}, {"family": "Kim", "given": "Changil", "initials": "C", "orcid": "0000-0003-4977-4384", "researcher": {"href": "https://publications.scilifelab.se/researcher/f2212e39632b4184b3dfa8f985b87221.json"}}, {"family": "Cagigi", "given": "Alberto", "initials": "A"}, {"family": "Gagne", "given": "Matthew", "initials": "M", "orcid": "0000-0001-5526-6162", "researcher": {"href": "https://publications.scilifelab.se/researcher/ca410207419743c4a8a5b609d5941459.json"}}, {"family": "Davis", "given": "Brandon", "initials": "B"}, {"family": "Germosen", "given": "Daritza", "initials": "D"}, {"family": "Roy", "given": "Vicky", "initials": "V", "orcid": "0000-0002-5064-1098", "researcher": {"href": "https://publications.scilifelab.se/researcher/d7215b0bed734c9b88fe892cf3cd94ea.json"}}, {"family": "Alter", "given": "Galit", "initials": "G"}, {"family": "Letscher", "given": "H\u00e9l\u00e8ne", "initials": "H"}, {"family": "Van Wassenhove", "given": "J\u00e9r\u00f4me", "initials": "J", "orcid": "0000-0001-7298-465X", "researcher": {"href": "https://publications.scilifelab.se/researcher/059f7210f3ba486984768bf32f7dbc41.json"}}, {"family": "Gros", "given": "Wesley", "initials": "W"}, {"family": "Gallou\u00ebt", "given": "Anne-Sophie", "initials": "AS"}, {"family": "Le Grand", "given": "Roger", "initials": "R", "orcid": "0000-0002-4928-4484", "researcher": {"href": "https://publications.scilifelab.se/researcher/e0b9f73082164b0092d9483ff474fc1c.json"}}, {"family": "Kleanthous", "given": "Harry", "initials": "H", "orcid": "0000-0001-7115-235X", "researcher": {"href": "https://publications.scilifelab.se/researcher/f590083a978347d5b2c329d4400dabd6.json"}}, {"family": "Guebre-Xabier", "given": "Mimi", "initials": "M"}, {"family": "Murrell", "given": "Ben", "initials": "B", "orcid": "0000-0002-0393-4445", "researcher": {"href": "https://publications.scilifelab.se/researcher/8a899203048943489bf7b6310a32b19f.json"}}, {"family": "Patel", "given": "Nita", "initials": "N"}, {"family": "Glenn", "given": "Gregory", "initials": "G"}, {"family": "Smith", "given": "Gale", "initials": "G", "orcid": "0000-0002-6482-6026", "researcher": {"href": "https://publications.scilifelab.se/researcher/1b50ad721d0a45b2957eb38a7afd803c.json"}}, {"family": "Lor\u00e9", "given": "Karin", "initials": "K", "orcid": "0000-0001-7679-9494", "researcher": {"href": "https://publications.scilifelab.se/researcher/737245a5bc2144bd90be71487cbb3192.json"}}], "type": "journal article", "published": "2024-01-20", "journal": {"title": "NPJ Vaccines", "issn": "2059-0105", "issn-l": null, "volume": "9", "issue": "1", "pages": "17"}, "abstract": "The immune responses to Novavax's licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-MTM adjuvanted vaccines predominantly elicits immune events in local tissues with little spillover to the periphery. A third dose of an updated vaccine based on the Gamma (P.1) variant 7 months after two immunizations with licensed NVX-CoV2373 resulted in significant enhancement of anti-spike antibody titers and antibody breadth including neutralization of forward drift Omicron variants. The third immunization expanded the Spike-specific memory B cell pool, induced significant somatic hypermutation, and increased serum antibody avidity, indicating considerable affinity maturation. Seven months after immunization, vaccinated animals controlled infection by either WA-1 or P.1 strain, mediated by rapid anamnestic antibody and T cell responses in the lungs. In conclusion, a third immunization with an adjuvanted, low-dose recombinant protein vaccine significantly improved the quality of B cell responses, enhanced antibody breadth, and provided durable protection against SARS-CoV-2 challenge.", "doi": "10.1038/s41541-024-00806-2", "pmid": "38245545", "labels": {"Affinity Proteomics Stockholm": "Service", "Bioinformatics Support for Computational Resources": "Service", "Affinity Proteomics Uppsala": "Service"}, "xrefs": [{"db": "pmc", "key": "PMC10799869"}, {"db": "pii", "key": "10.1038/s41541-024-00806-2"}], "notes": [], "created": "2024-10-08T15:06:47.828Z", "modified": "2025-02-28T14:15:13.257Z"}