{"entity": "publication", "iuid": "936f5cb423c14280a19d6cd9d5cc66cc", "timestamp": "2026-09-12T19:25:50.653Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/936f5cb423c14280a19d6cd9d5cc66cc.json"}, "display": {"href": "https://publications.scilifelab.se/publication/936f5cb423c14280a19d6cd9d5cc66cc"}}, "title": "Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis.", "authors": [{"family": "Lourido", "given": "Luc\u00eda", "initials": "L"}, {"family": "Joshua", "given": "Vijay", "initials": "V"}, {"family": "Hansson", "given": "Monika", "initials": "M"}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R"}, {"family": "Pin", "given": "Elisa", "initials": "E"}, {"family": "Ruiz-Romero", "given": "Cristina", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "Alfredsson", "given": "Lars", "initials": "L"}, {"family": "Klareskog", "given": "Lars", "initials": "L"}, {"family": "Blanco", "given": "Francisco J", "initials": "FJ"}], "type": "journal article", "published": "2024-01-09", "journal": {"title": "Rheumatology (Oxford)", "issn": "1462-0332", "issn-l": "1462-0324"}, "abstract": "To discover autoantibodies to non-modified proteins associated with the presence/absence of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA).\n\nThe autoantibody repertoire of 80 ACPA negative and 80 ACPA positive RA subjects from the Swedish population-based Epidemiological Investigation of RA (EIRA) cohort was screened using a suspension bead array built on protein fragments earlier described as autoimmunity targets. Four autoantibodies positive in the initial screening were validated in another set of EIRA samples containing 317 ACPA-positive, 302 ACPA-negative and 372 age- and sex-matched controls. The relationship between the four autoantibodies and lung abnormalities on high-resolution computed tomography (HRTC) was examined in 93 early RA patients from LURA cohort. Association between the autoantibodies, smoking and MHC class II alleles was assessed by logistic regression analysis.\n\n: Anti-ANOS1 and anti-MURC IgG levels were associated with ACPA-positive status (OR = 3.02; 95% CI 1.87-4.89; and OR = 1.86; 95% CI 1.16-2.97, respectively) and increased in ACPA-positive patients compared with controls. Anti-ANOS1 IgG was associated with smoking habit (OR = 2.11; 95% CI 1.22-3.69) and anti-MURC IgG with the presence of the MHC class II \"shared-epitope\" genes (OR = 1.95; 95% CI 1.11-3.46). Anti-TSPYL4 IgG was associated with ACPA-negative (OR = 0.41; 95% CI 0.19-0.89). Anti-TSPYL4 IgG and anti-MAP2K6 IgG levels were increased in the ACPA-negative patients compared with controls. Presence of anti-MAP2K6 IgG and anti-TSPYL4 IgG correlated negatively with HRCT-defined lung abnormalities.\n\nThese four autoantibodies may be useful in diagnostics and in predicting clinical phenotypes of RA.", "doi": "10.1093/rheumatology/keae007", "pmid": "38195995", "labels": {"Autoimmunity and Serology Profiling": "Collaborative"}, "xrefs": [{"db": "pii", "key": "7513696"}], "notes": [], "created": "2024-09-04T07:30:38.578Z", "modified": "2024-09-04T07:30:38.582Z"}