{"entity": "publication", "iuid": "8f6ae3f4a79d4fa49e24d158da645cd7", "timestamp": "2026-07-22T14:35:10.509Z", "links": {"self": {"href": "https://publications.scilifelab.se/publication/8f6ae3f4a79d4fa49e24d158da645cd7.json"}, "display": {"href": "https://publications.scilifelab.se/publication/8f6ae3f4a79d4fa49e24d158da645cd7"}}, "title": "Transcriptomics and Targeted Proteomics Analysis to Gain Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers.", "authors": [{"family": "Zhang", "given": "Wang", "initials": "W"}, {"family": "Ambikan", "given": "Anoop T", "initials": "AT"}, {"family": "Sperk", "given": "Maike", "initials": "M"}, {"family": "van Domselaar", "given": "Robert", "initials": "R"}, {"family": "Nowak", "given": "Piotr", "initials": "P"}, {"family": "Noyan", "given": "Kajsa", "initials": "K"}, {"family": "Russom", "given": "Aman", "initials": "A"}, {"family": "S\u00f6nnerborg", "given": "Anders", "initials": "A"}, {"family": "Neogi", "given": "Ujjwal", "initials": "U"}], "type": "journal article", "published": "2017-12-12", "journal": {"volume": null, "issn": "2352-3964", "issue": null, "title": "EBioMedicine", "issn-l": "2352-3964"}, "abstract": "A small subset of HIV-1 infected individuals, the \"Elite Controllers\" (EC), can control viral replication and restrain progression to immunodeficiency without antiretroviral therapy (ART). In this study, a cross-sectional transcriptomics and targeted proteomics analysis were performed in a well-defined Swedish cohort of untreated EC (n=19), treatment na\u00efve patients with viremia (VP, n=32) and HIV-1-negative healthy controls (HC, n=23). The blood transcriptome identified 151 protein-coding genes that were differentially expressed (DE) in VP compared to EC. Genes like CXCR6 and SIGLEC1 were downregulated in EC compared to VP. A definite distinction in gene expression between males and females among all patient-groups were observed. The gene expression profile between female EC and the healthy females was similar but did differ between male EC and healthy males. At targeted proteomics analysis, 90% (29/32) of VPs clustered together while EC and HC clustered separately from VP. Among the soluble factors, 33 were distinctive to be statistically significant (False discovery rate=0.02). Cell surface receptor signaling pathway, programmed cell death, response to cytokine and cytokine-mediated signaling seem to synergistically play an essential role in HIV-1 control in EC.", "doi": "10.1016/j.ebiom.2017.11.031", "pmid": "29269040", "labels": {"National Genomics Infrastructure": "Service", "NGI Stockholm (Genomics Applications)": "Service", "NGI Stockholm (Genomics Production)": "Service"}, "xrefs": [{"db": "pii", "key": "S2352-3964(17)30473-5"}, {"db": "BioProject", "description": "Transcriptomic analysis to map mechanisms of viral replication control in HIV-1 positive Elite Controllers", "key": "PRJNA420459"}, {"db": "SRA", "description": "Transcriptomic analysis to map mechanisms of viral replication control in HIV-1 positive Elite Controllers", "key": "SRP125882"}], "notes": [], "created": "2018-01-10T09:45:01.949Z", "modified": "2020-01-21T13:56:11.033Z"}